DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and ADAMTS8

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_008968.4	Gene:	ADAMTS8 / 11095	HGNCID:	224	Length:	889	Species:	Homo sapiens

Alignment Length:	789	Identity:	186/789 - (23%)
Similarity:	287/789 - (36%)	Gaps:	223/789 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 LERCFYRSPA-------AALDLCEPGNVRGVFQQNGSDLVIHPLPA-----------RFG-TGTH 237
            |..||:....       ||:.||.  .:.|.|..:|.:..|.|..|           |:| .|..
Human    97 LRGCFFSGTVNGEPESLAAVSLCR--GLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGAR 159

  Fly   238 VLYQA---RVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQP 299
            .|.:.   .|:...|...|....:..|..:||   |.:||..:||...|.|.|
Human   160 PLPRGPEWEVETGEGQRQERGDHQEDSEEESQ---EEEAEGASEPPPPLGATS------------ 209

  Fly   300 RHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLL 364
                       |.:|::.:|           .|:||.:..|:.:.|....:...:        :|
Human   210 -----------RTKRFVSEA-----------RFVETLLVADASMAAFYGADLQNH--------IL 244

  Fly   365 AMINGVQLLYHHPTLGRRINFVLKRLEIW--KSWDPP-----GLVRSRDVENYLNSFCKWQEKLN 422
            .:::....:|.||::...||.::.::.|.  :.|.|.     ||.        |.:||.||.:.|
Human   245 TLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLT--------LRNFCNWQRRFN 301

  Fly   423 PFSDADPLHYDHALVLT--------GLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHF 479
            ..||..|.|||.|::||        ||           ...:|:|.:..:|....||::.|.:..
Human   302 QPSDRHPEHYDTAILLTRQNFCGQEGL-----------CDTLGVADIGTICDPNKSCSVIEDEGL 355

  Fly   480 ESVFVVAHEIGHNLGMRHDAKEISCDPTM------HIMSPKLG--SGKVTWSKCSRTYLEDFLMD 536
            ::...:|||:||.|.|.||..: .|....      |:|:|...  :..:.||.||..||.:.|..
Human   356 QAAHTLAHELGHVLSMPHDDSK-PCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDG 419

  Fly   537 PQAECLFDRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQASTQSKMEICRDLHCRQDG- 600
            ...:||.|..:.|.|......||:  ..:..:|||...||.:|......|..::|..|.|..||
Human   420 GHGDCLLDAPAAALPLPTGLPGRM--ALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGA 482

  Fly   601 ----------LPWTSHPALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKII 655
                      |||.     :||.|||...|..|:|                    :||   |::.
Human   483 EPLCHTKNGSLPWA-----DGTPCGPGHLCSEGSC--------------------LPE---EEVE 519

  Fly   656 RHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSC-- 718
            |.:|               ...|..:.||.|.|   |...|           ..|::..:|.|
Human   520 RPKP---------------VADGGWAPWGPWGE---CSRTC-----------GGGVQFSHRECKD 555

  Fly   719 ---LNFPSRCIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSD-PELTGE-GQQLPSTLD 778
               .|....|:||..::.:|:|.:|   |... ..|..|.|.:....: .::.|. .|.:|....
Human   556 PEPQNGGRYCLGRRAKYQSCHTEEC---PPDG-KSFREQQCEKYNAYNYTDMDGNLLQWVPKYAG 616

  Fly   779 AS----CKIFCRTRTNGTKSRRWTFP----DGTTCKAKQHNPEDITYCISGRCERFSCDNSTSNF 835
            .|    ||:|||.|   .:|....|.    |||.|     .||.:..|:.|:|.:..||:...:.
Human   617 VSPRDRCKLFCRAR---GRSEFKVFEAKVIDGTLC-----GPETLAICVRGQCVKAGCDHVVDSP 673

  Fly   836 FKMDS-SFCEAR---------SVRPTRDSSDQESRQQTNRQRYAERQEGKPQKNHYENEVAKRPS 890
            .|:|. ..|..:         |:.||....:..............:|...|...:..|.:|.:.:
Human   674 RKLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTA 738

  Fly   891 YGQ----GN 895
            .||    ||
Human   739 DGQYLLNGN 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	16/65 (25%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	60/234 (26%)
		Reprolysin	332..545	CDD:279729	61/235 (26%)
		TSP1	683..741	CDD:214559	15/62 (24%)
ADAMTS8	NP_008968.4	Pep_M12B_propep	50..150	CDD:279848	13/54 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..210		19/97 (20%)
		Reprolysin	219..429	CDD:279729	62/237 (26%)
		ZnMc_ADAMTS_like	219..426	CDD:239801	60/234 (26%)
		ADAM_CR	448..514	CDD:301627	23/90 (26%)
		TSP1	529..581	CDD:214559	16/68 (24%)
		Spacer	690..831		11/58 (19%)
		ADAM_spacer1	690..809	CDD:283607	11/58 (19%)
		TSP1	836..888	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810