Protein Alignment stl and ADAMTS13

DIOPT Version :9

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: NP_620594.1
• Gene: ADAMTS13 / 11093
• HGNCID: 1366
• Length: 1427
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 160/570 - (28%)
• Similarity: 233/570 - (40%)
• Gaps: 132/570 - (23%)

  Fly   306 QHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLY-AHMQKNFPTNTESKVVSFLLAMIN- 368
            |..:||:||..|..           |.:|..:.|..|:: ||.:     :||    .::|..:|
Human    66 QRQRQRQRRAAGGI-----------LHLELLVAVGPDVFQAHQE-----DTE----RYVLTNLNI 110

  Fly   369 GVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVR-SRDVENYLNSFCKWQEKLNPFSDADPLHY 432
            |.:|| ..|:||.:....|.::.|..  :|.|... :.::.:.|.|.|.|.:.:||..|.||.|.
Human   111 GAELL-RDPSLGAQFRVHLVKMVILT--EPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHA 172

  Fly   433 DHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRH 497
            |..|.:|..||...|   .|.||.|:..:.|.|:..:||.|.|...|:....:||||||:.|:.|
Human   173 DLVLYITRFDLELPD---GNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEH 234

  Fly   498 D-AKEISCDPTMHIM-----SPKLGSGKVTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTA 556
            | |....|.|:.|:|     :|:.|   :.||.|||..|...|...:|.|::|...   |...:|
Human   235 DGAPGSGCGPSGHVMASDGAAPRAG---LAWSPCSRRQLLSLLSAGRARCVWDPPR---PQPGSA 293

  Fly   557 G---GRLPGERFNANQQCMLRFGKNFMQAS-TQSKMEICRDLHCRQDGLPWTS-----HPALEGT 612
            |   ...||..::||:||.:.||...:..: .:..:::|:.|.|..|.|..:|     .|.|:||
Human   294 GHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGT 358

  Fly   613 ECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELP 677
            |||...||..|.|.:                                      |.:..|    :.
Human   359 ECGVEKWCSKGRCRS--------------------------------------LVELTP----IA 381

  Fly   678 GSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLN----FPSR-CIGRDRRFVTCNT 737
            .....|..|...|.|...|           ..|:.|..|.|.|    |..| |:|.|.:...|||
Human   382 AVHGRWSSWGPRSPCSRSC-----------GGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNT 435

  Fly   738 PQCHKVPVQTINDFATQVCM----QARKSDP---ELTGEGQQLP-STLDASCKIFCRTRTNGTKS 794
            ..|.|..:    :|.:|.|.    |..:|.|   .....|..:| |..||.|:..||........
Human   436 QACEKTQL----EFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIM 496

  Fly   795 RRW-TFPDGTTCKAKQHNPED---ITYCISGRCERFSCDNSTSNFFKMDS 840
            :|. :|.|||.|...  .|.:   ::.|:||.|..|.||.      :|||
Human   497 KRGDSFLDGTRCMPS--GPREDGTLSLCVSGSCRTFGCDG------RMDS 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848
		ZnMc_ADAMTS_like	331..543	CDD:239801	72/220 (33%)
		Reprolysin	332..545	CDD:279729	71/221 (32%)
		TSP1	683..741	CDD:214559	18/62 (29%)
ADAMTS13	NP_620594.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..70		1/3 (33%)
		ZnMc_ADAMTS_like	80..283	CDD:239801	72/220 (33%)
		TSP1	387..439	CDD:214559	18/62 (29%)
		Cysteine-rich	440..556		32/111 (29%)
		Cell attachment site. /evidence=ECO:0000255	498..500		1/1 (100%)
		Spacer	556..685
		ADAM_spacer1	559..680	CDD:283607

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810