Protein Alignment stl and Adamts7

DIOPT Version :10

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: NP_001313280.1
• Gene: Adamts7 / 108153
• MGIID: 1347346
• Length: 1657
• Species: Mus musculus
• Alignment Length: 970
• Identity: 232/970 - (23%)
• Similarity: 352/970 - (36%)
• Gaps: 323/970 - (33%)

  Fly   153 EARLQLQQSPQLIDDAFIF-IRRTEN-GTQFVEHSP---QLLKRLERCFYRSPAAALDLCEPGNV 212
            |....|..:|.|:...|:. |||... |...::.|.   .||..::........||:..|:  .:
Mouse    80 ELLFNLTTNPYLMAPGFVSEIRRHSTLGHAHIQTSVPTCHLLGDVQDPELEGGFAAISACD--GL 142

  Fly   213 RGVFQQNGSDLVIHPL---PARFG-TGTHVLYQARVDKSGGGYSEASSRRTASPLDSQ------L 267
            |||||.:..|..|.||   .|:.| ...||:|:           ...||:.|...||:      :
Mouse   143 RGVFQLSNEDYFIEPLDGVSAQPGHAQPHVVYK-----------HQGSRKQAQQGDSRPSGTCGM 196

  Fly   268 QFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELF 332
            |..||.|:..|                          |...||::||......:.:|
Mouse   197 QVPPDLEQQRE--------------------------HWEQQQQKRRQQRSVSKEKW-------- 227

  Fly   333 IETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWD 397
            :||.:..||.:..:       :.:.:|.|::|.::|.|..|:|.|::|..|:..:.||.|.:. :
Mouse   228 VETLVVADSKMVEY-------HGQPQVESYVLTIMNMVAGLFHDPSIGNPIHISIVRLIILED-E 284

  Fly   398 PPGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANS--QVVGMAT 460
            ...|..:...|..|.:||:||:.:|...|..|.|:|.|::||..||.    ...|.  :.:|::.
Mouse   285 EKDLKITHHAEETLKNFCRWQKNINIKGDDHPQHHDTAILLTRKDLC----ASMNQPCETLGLSH 345

  Fly   461 VKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCD---PTMHIMSPKLGSGK--- 519
            |.|:|....||:::|.......|.||||:||:.|::||.....|:   ....||||:|...:
Mouse   346 VSGLCHPQLSCSVSEDTGMPLAFTVAHELGHSFGIQHDGTGNDCESIGKRPFIMSPQLLYDRGIP 410

  Fly   520 VTWSKCSRTYLEDFLMDPQAECLFDR---DSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQ 581
            :|||:|||.|:..||......||.||   |..|.|      ..|||..::.|.||.|::|.:  .
Mouse   411 LTWSRCSREYITRFLDRGWGLCLDDRPSKDVIALP------SVLPGVLYDVNHQCRLQYGSH--S 467

  Fly   582 ASTQSKMEICRDLHCRQDGLPWTSH----PALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWP 642
            |..:...::|..|.|   .:..|.|    .|::||.||.|.||..|.|
Mouse   468 AYCEDMDDVCHTLWC---SVGTTCHSKLDAAVDGTSCGKNKWCLKGEC----------------- 512

  Fly   643 PEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEG 707
               :||.                   :.|  ..:.|..|.|..||:   |...|
Mouse   513 ---VPEG-------------------FQP--EAVDGGWSGWSAWSD---CSRSC----------- 539

  Fly   708 STGLRTLNRSCL-----NFPSRCIGRDRRFVTCNTPQC------------------------HK- 742
            ..|:|:..|.|.     |....|:|..:|...||.|.|                        ||
Mouse   540 GVGVRSSERQCTQPVPKNRGKYCVGERKRSQLCNLPACPPDRPSFRHTQCSQFDGMLYKGKLHKW 604

  Fly   743 VPVQTINDFATQVCMQARKSDPELTGEGQQLPSTLDASCKIFCR-TRTNGTKSRRWTFPDGTTCK 806
            |||.  ||                           |..|::.|| :.::.|:..|....|||.|.
Mouse   605 VPVP--ND---------------------------DNPCELHCRPSNSSNTEKLRDAVVDGTPCY 640

  Fly   807 AKQHNPEDITYCISGRCERFSCDNSTSNFFKMDSSFCEARS--VRPTRDSSDQESR--QQTNRQR 867
            ..:.: .||  |::|.|:...||      |.:||...|.|.  .|....:....||  ::|..|.
Mouse   641 QSRIS-RDI--CLNGICKNVGCD------FVIDSGAEEDRCGVCRGDGSTCQTVSRTFKETEGQG 696

  Fly   868 YAE-------------------------RQEGK--------------------------PQKNHY 881
            |.:                         |.|..                          .:|.::
Mouse   697 YVDIGLIPAGAREILIEEVAEAANFLALRSEDPDKYFLNGGWTIQWNGDYRVAGTTFTYARKGNW 761

  Fly   882 ENEVAKRPS---------YGQGNHINAPASPYK---RRNYHKPYPPEIPRPPPPASASLIALDRS 934
            ||..:..|:         :.:.|    |...|:   :|:.|     :..|||
Mouse   762 ENLTSPGPTSEPVWIQLLFQEKN----PGVHYQYTIQRDSH-----DQVRPP------------- 804

  Fly   935 SSSESEWVAHPGCHSNC-MTDSKGVQGVT----SRLTGVESIQLCSYRIQPCERLQTAAE 989
               |..|  |.|..|.| :|...|||..:    .|..||.:.:.|:...:|.||.:..:|
Mouse   805 ---EFSW--HYGPWSKCTVTCGTGVQRQSLYCMERQAGVVAEEYCNTLNRPDERQRKCSE 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	68/219 (31%)
		ADAMTS_CR_2	561..625	CDD:465496	22/67 (33%)
		TSP1	683..741	CDD:214559	17/86 (20%)
Adamts7	NP_001313280.1	Pep_M12B_propep	34..174	CDD:460254	28/95 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..221		19/92 (21%)
		Cysteine switch. /evidence=ECO:0000250	192..199		1/6 (17%)
		ZnMc_ADAMTS_like	226..434	CDD:239801	69/227 (30%)
		ADAMTS_CR_2	449..513	CDD:465496	23/88 (26%)
		TSP1	526..578	CDD:214559	17/65 (26%)
		ADAMTS_CR_3	584..682	CDD:437068	30/135 (22%)
		Spacer	683..794		14/114 (12%)
		ADAMTS_spacer1	684..793	CDD:461796	14/112 (13%)
		TSP1_ADAMTS	808..862	CDD:465950	17/54 (31%)
		TSP1_ADAMTS	866..922	CDD:465950
		TSP1_ADAMTS	929..977	CDD:465950
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1009..1034
		PHA03247	<1065..1403	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1073..1127
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1140..1237
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1283..1304
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1317..1384
		TSP1_ADAMTS	1386..1434	CDD:465950
		TSP1_ADAMTS	1437..1492	CDD:465950
		TSP1_ADAMTS	1495..1541	CDD:465950
		TSP1_ADAMTS	1544..1599	CDD:465950