DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stl and Adamts7

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001313280.1	Gene:	Adamts7 / 108153	MGIID:	1347346	Length:	1657	Species:	Mus musculus

Alignment Length:	970	Identity:	232/970 - (23%)
Similarity:	352/970 - (36%)	Gaps:	323/970 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 EARLQLQQSPQLIDDAFIF-IRRTEN-GTQFVEHSP---QLLKRLERCFYRSPAAALDLCEPGNV 212
            |....|..:|.|:...|:. |||... |...::.|.   .||..::........||:..|:  .:
Mouse    80 ELLFNLTTNPYLMAPGFVSEIRRHSTLGHAHIQTSVPTCHLLGDVQDPELEGGFAAISACD--GL 142

  Fly   213 RGVFQQNGSDLVIHPL---PARFG-TGTHVLYQARVDKSGGGYSEASSRRTASPLDSQ------L 267
            |||||.:..|..|.||   .|:.| ...||:|:           ...||:.|...||:      :
Mouse   143 RGVFQLSNEDYFIEPLDGVSAQPGHAQPHVVYK-----------HQGSRKQAQQGDSRPSGTCGM 196

  Fly   268 QFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELF 332
            |..||.|:..|                          |...||::||......:.:|
Mouse   197 QVPPDLEQQRE--------------------------HWEQQQQKRRQQRSVSKEKW-------- 227

  Fly   333 IETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWD 397
            :||.:..||.:..:       :.:.:|.|::|.::|.|..|:|.|::|..|:..:.||.|.:. :
Mouse   228 VETLVVADSKMVEY-------HGQPQVESYVLTIMNMVAGLFHDPSIGNPIHISIVRLIILED-E 284

  Fly   398 PPGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANS--QVVGMAT 460
            ...|..:...|..|.:||:||:.:|...|..|.|:|.|::||..||.    ...|.  :.:|::.
Mouse   285 EKDLKITHHAEETLKNFCRWQKNINIKGDDHPQHHDTAILLTRKDLC----ASMNQPCETLGLSH 345

  Fly   461 VKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCD---PTMHIMSPKLGSGK--- 519
            |.|:|....||:::|.......|.||||:||:.|::||.....|:   ....||||:|...:
Mouse   346 VSGLCHPQLSCSVSEDTGMPLAFTVAHELGHSFGIQHDGTGNDCESIGKRPFIMSPQLLYDRGIP 410

  Fly   520 VTWSKCSRTYLEDFLMDPQAECLFDR---DSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQ 581
            :|||:|||.|:..||......||.||   |..|.|      ..|||..::.|.||.|::|.:  .
Mouse   411 LTWSRCSREYITRFLDRGWGLCLDDRPSKDVIALP------SVLPGVLYDVNHQCRLQYGSH--S 467

  Fly   582 ASTQSKMEICRDLHCRQDGLPWTSH----PALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWP 642
            |..:...::|..|.|   .:..|.|    .|::||.||.|.||..|.|
Mouse   468 AYCEDMDDVCHTLWC---SVGTTCHSKLDAAVDGTSCGKNKWCLKGEC----------------- 512

  Fly   643 PEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEG 707
               :||.                   :.|  ..:.|..|.|..||:   |...|
Mouse   513 ---VPEG-------------------FQP--EAVDGGWSGWSAWSD---CSRSC----------- 539

  Fly   708 STGLRTLNRSCL-----NFPSRCIGRDRRFVTCNTPQC------------------------HK- 742
            ..|:|:..|.|.     |....|:|..:|...||.|.|                        ||
Mouse   540 GVGVRSSERQCTQPVPKNRGKYCVGERKRSQLCNLPACPPDRPSFRHTQCSQFDGMLYKGKLHKW 604

  Fly   743 VPVQTINDFATQVCMQARKSDPELTGEGQQLPSTLDASCKIFCR-TRTNGTKSRRWTFPDGTTCK 806
            |||.  ||                           |..|::.|| :.::.|:..|....|||.|.
Mouse   605 VPVP--ND---------------------------DNPCELHCRPSNSSNTEKLRDAVVDGTPCY 640

  Fly   807 AKQHNPEDITYCISGRCERFSCDNSTSNFFKMDSSFCEARS--VRPTRDSSDQESR--QQTNRQR 867
            ..:.: .||  |::|.|:...||      |.:||...|.|.  .|....:....||  ::|..|.
Mouse   641 QSRIS-RDI--CLNGICKNVGCD------FVIDSGAEEDRCGVCRGDGSTCQTVSRTFKETEGQG 696

  Fly   868 YAE-------------------------RQEGK--------------------------PQKNHY 881
            |.:                         |.|..                          .:|.::
Mouse   697 YVDIGLIPAGAREILIEEVAEAANFLALRSEDPDKYFLNGGWTIQWNGDYRVAGTTFTYARKGNW 761

  Fly   882 ENEVAKRPS---------YGQGNHINAPASPYK---RRNYHKPYPPEIPRPPPPASASLIALDRS 934
            ||..:..|:         :.:.|    |...|:   :|:.|     :..|||
Mouse   762 ENLTSPGPTSEPVWIQLLFQEKN----PGVHYQYTIQRDSH-----DQVRPP------------- 804

  Fly   935 SSSESEWVAHPGCHSNC-MTDSKGVQGVT----SRLTGVESIQLCSYRIQPCERLQTAAE 989
               |..|  |.|..|.| :|...|||..:    .|..||.:.:.|:...:|.||.:..:|
Mouse   805 ---EFSW--HYGPWSKCTVTCGTGVQRQSLYCMERQAGVVAEEYCNTLNRPDERQRKCSE 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	26/92 (28%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	68/219 (31%)
		Reprolysin	332..545	CDD:279729	69/220 (31%)
		TSP1	683..741	CDD:214559	17/86 (20%)
Adamts7	NP_001313280.1	Pep_M12B_propep	58..173	CDD:279848	27/94 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..221		19/92 (21%)
		Cysteine switch. /evidence=ECO:0000250	192..199		1/6 (17%)
		Reprolysin	226..437	CDD:279729	71/230 (31%)
		ZnMc_ADAMTS_like	226..434	CDD:239801	69/227 (30%)
		TSP1	526..578	CDD:214559	17/65 (26%)
		ADAM_spacer1	683..794	CDD:283607	14/114 (12%)
		Spacer	683..794		14/114 (12%)
		TSP1	808..863	CDD:214559	17/54 (31%)
		TSP1	927..977	CDD:214559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1009..1034
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1073..1127
		MISS	1083..1334	CDD:292450
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1140..1237
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1283..1304
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1317..1384
		TSP1	1437..1492	CDD:214559
		TSP1	1541..1600	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810