DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and Adamts13

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_006233941.3	Gene:	Adamts13 / 102554393	RGDID:	1311594	Length:	1482	Species:	Rattus norvegicus

Alignment Length:	711	Identity:	186/711 - (26%)
Similarity:	267/711 - (37%)	Gaps:	195/711 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 CFYRSPAAALDLCEPGNVRGVFQQNGSD---------------------LVIHPLPARFGTGTHV 238
            |..|.|..:|..|.|    ||..||.|.                     |...|..|....|  :
  Rat    20 CRDREPLTSLSSCRP----GVSSQNESQSPGLPSGHRLPVLRMSQLCLWLPCQPFLAASIRG--I 78

  Fly   239 LYQARVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHH 303
            |..|.......|.|           |.|..|..|.    ||:       .|.|.......|...|
  Rat    79 LTGAIFILGCWGLS-----------DFQKSFLQDL----EPK-------DLSSSFSRHTAPLTGH 121

  Fly   304 PHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLY-AHMQKNFPTNTESKVVSFLLAMI 367
            |..|.|:.|:|...:       ||   |.:|..:.|..|:| ||.:     :||    .::|..:
  Rat   122 PSSHLQRLRQRRTSE-------DI---LHLELLVAVGPDVYQAHQE-----DTE----RYVLTNL 167

  Fly   368 N-GVQLLYHHPTLGRRINFVLKRLEIWK-SWDPPGLVRSRDVENYLNSFCKWQEKLNPFSDADPL 430
            | |.:|| .:|:||.::...|.:|.|.. |.:.|.:  :.::.:.|.|.|:|.:.:||..|.||.
  Rat   168 NIGSELL-RNPSLGAQLQVHLVKLIILSDSENTPNI--TTNITSSLMSVCEWSQTINPHDDRDPS 229

  Fly   431 HYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGM 495
            |.|..:.:|..||...|   .|.||.|:....|.|:..:||.|.|...|:....:||||||:.|:
  Rat   230 HADLIIYITRFDLELPD---GNQQVRGVTQQGGACSPSWSCLITEDTGFDLGVTIAHEIGHSFGL 291

  Fly   496 RHDAKEIS---CDPTMHIMS-----PKLGSGKVTWSKCSRTYLEDFLMDPQAECLFDRDSFAG-- 550
            .||....|   |:...|:|:     |  ..|.:.||.||:..|:..|...|..||:|......
  Rat   292 DHDGAPGSGSTCEARGHVMASDGAVP--AGGALEWSTCSQRQLQHLLSTGQMHCLWDPPGLQSGL 354

  Fly   551 PWDHTAGGRLPGERFNANQQCMLRFGKNFMQASTQSK--MEICRDLHCRQDGLPWTS-----HPA 608
            .|.....  .||..::|:.||.:.||...: |.|.|:  :::|:.|.|..|.|..:|     .|.
  Rat   355 TWHQLVA--QPGLFYSADDQCRVAFGAGAV-ACTFSREGLDVCQALSCHTDPLDQSSCSRLLVPL 416

  Fly   609 LEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMD 673
            |:|||||...||....|.:.:              |..|.|               ::|
  Rat   417 LDGTECGVEKWCSKARCRSLA--------------ELAPVA---------------VVH------ 446

  Fly   674 NELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLN----FPSR-CIGRDRRFV 733
                   .:|..|...|.|...|           ..|:.|..|.|.|    |..| |:|.|.:..
  Rat   447 -------GHWSSWGPHSPCSRSC-----------GGGVITRRRWCNNPRPAFGGRACVGEDLQAK 493

  Fly   734 TCNTPQCHKVPVQTINDFATQVCMQARKSDPELT---------------GEGQQLPSTLDASCKI 783
            .|||..|.|..:    :|.::.|.|..:...:|:               .:|       |..|:.
  Rat   494 MCNTQACEKTQL----EFMSEQCAQTDRHPLQLSQGSASFYHWDAAVQYSQG-------DTLCRH 547

  Fly   784 FC-RTRTNGTKSRRWTFPDGTTCKAKQHNPED---ITYCISGRCERFSCDNSTSNFFKMDS 840
            .| ....:...||..:|.|||.|  ..:.|.:   ::.|:.|.|..|.||.      ||||
  Rat   548 MCWAVGESFIVSRGDSFLDGTRC--VPNGPREDGTVSLCLLGSCRTFGCDG------KMDS 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	15/64 (23%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	71/222 (32%)
		Reprolysin	332..545	CDD:279729	71/223 (32%)
		TSP1	683..741	CDD:214559	18/62 (29%)
Adamts13	XP_006233941.3	ZnMc_ADAMTS_like	139..345	CDD:239801	71/222 (32%)
		ADAM_CR_2	363..433	CDD:407643	25/70 (36%)
		TSP1	449..501	CDD:214559	18/62 (29%)
		TSP1_ADAMTS	755..804	CDD:408800
		TSP1_ADAMTS	808..866	CDD:408800
		TSP1_ADAMTS	960..1014	CDD:408800
		TSP1_ADAMTS	1018..1074	CDD:408800
		TSP1_ADAMTS	1078..1134	CDD:408800
		TSP1_ADAMTS	1138..1192	CDD:408800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910