DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and adamts17

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_021333385.1	Gene:	adamts17 / 101884120	ZFINID:	ZDB-GENE-121030-7	Length:	1134	Species:	Danio rerio

Alignment Length:	1106	Identity:	255/1106 - (23%)
Similarity:	392/1106 - (35%)	Gaps:	316/1106 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 PEEQQRLEERKRPGEAEQH---GGNPHQR-RQRRSLPSEDGNGPLPPEEEEQ------EAGEDVE 153
            |:|.|       ||  |.|   |||...| |:|||          .|::|:.      ..|:  |
Zfish    37 PQELQ-------PG--EMHLLSGGNRWSRGRKRRS----------DPQQEDHLFLRLPAFGK--E 80

  Fly   154 ARLQLQQSPQLIDDAFIFIRRTENGTQFVEHSPQLLKRLERCFYRSPA-------AALDLCEPGN 211
            ..|:||:....:.:.|:...|.|.|:  |:|  :.|.::.||||....       .:||.|  |.
Zfish    81 LYLELQRDASFLTEGFVTEERREEGS--VQH--ESLPKVRRCFYTGAILNHTDSFVSLDTC--GG 139

  Fly   212 VRGVFQQNGSDLVIHPLPARFGTGTHVLYQARVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEF 276
            :.|:.|.....|.|.|:             .:...|..|:.....|...|..|.........|:|
Zfish   140 LTGLVQTAEERLFIEPV-------------GQAADSFSGWEHRVIREKHSSPDGPAPAADGREQF 191

  Fly   277 NEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDS 341
                    .||       :..:.:...|....|.|.||   :|.|     :..|..:||.:..|:
Zfish   192 --------CQS-------IHDKKKEKRPRGAEQVRGRR---NAIR-----LSREYTVETLVVADA 233

  Fly   342 DLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRD 406
            ::..:       :.......|||.::|.|..::.|.:||.|:|..:.:|.:..: .|..|.....
Zfish   234 NMVQY-------HGAEAAQRFLLTVMNMVYNMFQHQSLGLRLNIRVTKLVLLHN-RPEKLKVGHH 290

  Fly   407 VENYLNSFCKWQEKLN----------PFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATV 461
            .|..|.|||.||.:..          |.|..||...|.|:::|..|...:.....::  ||:|.:
Zfish   291 GEKALESFCHWQHEEYGARYLGNNHVPGSRDDPPPVDAAVLVTRTDFCVHKDEPCDT--VGIAYL 353

  Fly   462 KGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPTMHIMSPKLGSGK----VTW 522
            .|.|:|...|.:.|.......|.:|||:|||:||.||....||....||||.:...|:    ::|
Zfish   354 GGTCSSKRKCVLAEDNGLNLAFTIAHELGHNMGMSHDDDHASCTGHSHIMSGEWVKGRNPSDLSW 418

  Fly   523 SKCSRTYLEDFLMDPQAECLFDRDSFAGPWDH---TAGGRLPGERFNANQQCMLRFGKNFMQAST 584
            |.|||..||.||....:.||...|    |.:.   ....:|||..::|::||.:.||.|   |:.
Zfish   419 STCSRDDLEKFLRSKASGCLLHTD----PRNRYLVRLPAKLPGMHYSADEQCQILFGTN---ATF 476

  Fly   585 QSKME--ICRDLHCRQDGLPWTS-----HPALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWP 642
            .:.||  :|..|.|..:|  .||     .|.|:|||||.:.|||.|.|.:::            |
Zfish   477 CTDMEHLMCAGLWCLVEG--DTSCKTKLDPPLDGTECGADKWCRAGECVSKT------------P 527

  Fly   643 -PEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLE 706
             |:|:                                 ..:|..||..|.|...|
Zfish   528 IPQHV---------------------------------DGDWSPWSTWSMCSRTC---------- 549

  Fly   707 GSTGLRTLNRSCLNFP-----SRCIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSDPEL 766
             .||.|...|.|.|.|     ..|.........|..|.|.| .:.|..|      .|.:..:.:.
Zfish   550 -GTGARFRQRKCDNPPPGPGGKYCQKASVEHKVCEGPPCTK-GLPTFRD------QQCQSHERQA 606

  Fly   767 TGEGQQLPSTLD--ASCKIFCRTRTNGTKSRRWTFP--------DGTTCKAKQHNPEDITYCISG 821
            :.:.|...:.:|  ..|.::|  ...|:.|     |        |||.|     .|.:...|::|
Zfish   607 SKKSQMWTAVIDDEKPCALYC--TPVGSDS-----PVLVAERVLDGTPC-----GPYESDLCVNG 659

  Fly   822 RCERFSCDNSTSNFFKMD-SSFC--EARSVRPTRDSSDQE------------SRQQTNRQR---- 867
            :|::..||....:..|.| ...|  :.:|.|..:...:..            |....::.|
Zfish   660 KCQKIGCDGIIGSSAKEDRCGVCNGDGKSCRIVKGDFNHSKGMVPHSLCKKVSTCVMSKPRAVLK 724

  Fly   868 ----YAERQ------------EGKPQKNHYENEVAKRPSYGQGNHINAPAS--------PYKRRN 908
                |.|..            |.||..:....:.:.:.|......|..|..        .|.||.
Zfish   725 CFSCYIEAAVIPVGARRIKVVEDKPSHSFLALKDSSKRSINNDWKIELPGEFELAGTTVRYVRRG 789

  Fly   909 YHKPYPPEIPRPPPPASASL--------------IALDRSSSSESEWVAHP------------GC 947
            ..:....:.|...|.....|              :||:.|..:.|:.|..|            .|
Zfish   790 LWEKMSAKGPTKTPLHLMVLLFHDQTYGIHYEYTVALNHSQENSSDLVKEPEHMYLWTHSSWEDC 854

  Fly   948 HSNCMTDSKGVQGVTSRLTGVESIQLCSYRIQPCERLQTAAEYAEQTCARYRQ------KVRGLS 1006
            ..:|        |...|.|.|..:::.:..:.|..  .::.:...:...:.||      :.|.::
Zfish   855 SVHC--------GGGERRTVVSCMRIINKTMTPVN--DSSCQVENKPSPQIRQCNIHPCQYRWVT 909

  Fly  1007 GHGAQISASIDEPDRSCRVGCQDEFIKYRYYLVNGRNGHFPPGTR---C---SPVGKRYCVYGRC 1065
            |...|.|.       :|..|.|...:...|.|   :||.:.| ||   |   .|...::|....|
Zfish   910 GDWTQCSL-------TCGKGLQQREVGCIYQL---QNGTYIP-TRDLYCLSSKPASVQHCEGRHC 963

  Fly  1066 L 1066
            |
Zfish   964 L 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	23/90 (26%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	67/225 (30%)
		Reprolysin	332..545	CDD:279729	68/226 (30%)
		TSP1	683..741	CDD:214559	16/62 (26%)
adamts17	XP_021333385.1	Pep_M12B_propep	33..170	CDD:307618	44/172 (26%)
		ZnMc_ADAMTS_like	223..439	CDD:239801	67/225 (30%)
		TSP1	536..587	CDD:214559	16/61 (26%)
		ADAM_spacer1	729..824	CDD:310520	14/94 (15%)
		TSP1	907..>931	CDD:214559	6/30 (20%)
		TSP1	966..1013	CDD:214559
		TSP1	1018..1070	CDD:214559
		PLAC	1099..1123	CDD:312271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810