DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and Adamts9

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_780523.3	Gene:	Adamts9 / 101401	MGIID:	1916320	Length:	1931	Species:	Mus musculus

Alignment Length:	1253	Identity:	262/1253 - (20%)
Similarity:	406/1253 - (32%)	Gaps:	429/1253 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 RSPEEAPEFKLVHLAQQRPEEQQRLEE-------RKRPGEAEQHGGNPHQRRQRRSLPSEDGNGP 138
            |||:.|...:...|..::.:..:.|.|       |..| ..|....|.|.:|:|||:.|  .:.|
Mouse    21 RSPDSAAAVRKDRLHPRQVKLLESLSEYEIASPIRVNP-LGEPFPTNVHFKRRRRSINS--ASDP 82

  Fly   139 LPPEEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTENG----------------TQFVEHSPQ 187
            .|.......:....:...:|....|    .|:|......|                .|...:|.:
Mouse    83 WPAFASSSSSSTSSQEHYRLSAFGQ----QFLFNLTAHTGFIAPLFTVTLLGEPGVNQTKLYSEE 143

  Fly   188 LLKRLERCFYR-------SPAAALDLCEPGNVRGVFQQNGSDLVIHPLPARFGTGTHVLYQARVD 245
            .:: |..|||:       ...|.:.||  ..:.|.|:.:..|..|.||.:             ||
Mouse   144 EME-LRHCFYKGHVNTKSEHTAVISLC--SGMMGTFRSHDGDYFIEPLQS-------------VD 192

  Fly   246 KSGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPR---------------RRLRAQSQLQS---- 291
            :                       :.|.||.|:|.               :...|.|:|::
Mouse   193 E-----------------------QEDEEEQNKPHIIYRHSTPQREPSTGKHACATSELKNSHSK 234

  Fly   292 ---PLRLRFQPRHHHPHQHHQQRRRRYIGD----------------------APRSRWSD----- 326
               .:|:|            ::|:|..:.|                      :.|.||:.
Mouse   235 DKRKIRMR------------KRRKRNSLADDVALLKSGLATKVLSGYSNQTNSTRDRWNHKRTKR 287

  Fly   327 -IPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRL 390
             :....|:|..:..|..:..:...|        :..::|.:::.|..:|...::|..||.|:..|
Mouse   288 FLSYPRFVEVMVVADHRMVLYHGAN--------LQHYILTLMSIVASIYKDSSIGNLINIVIVNL 344

  Fly   391 EIWKSWDPPGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQV 455
            .:..: :..|...:.:.:..|.:||:||...|....   :.:|.|:::|..|:.   :.:.....
Mouse   345 VVIHN-EQEGPYINFNAQTTLKNFCQWQHSKNYLGG---IQHDTAVLVTREDIC---RAQDKCDT 402

  Fly   456 VGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHD----AKEISCDPTMHIMSPKLG 516
            :|:|.:..:|....||:|:|.....:.|.:|||:||...|.||    .||.......|:|:|.|.
Mouse   403 LGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDSNKCKEEGVKSPQHVMAPTLN 467

  Fly   517 --SGKVTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHT--AGGRLPGERFNANQQCMLRFGK 577
              :....||||||.|:.:||.....|||.:.     |...|  ...:|||..:|.|:||.|.||.
Mouse   468 FYTNPWMWSKCSRKYITEFLDTGYGECLLNE-----PASRTYPLPSQLPGLLYNVNKQCELIFGP 527

  Fly   578 NFMQASTQSKMEICRDL--------H--CRQDGLPWTSHPALEGTECGPNMWCRGGTCEARSSKQ 632
            .   :.....|..||.|        |  ||....||.     :||||.|...|:.|.|.
Mouse   528 G---SQVCPYMMQCRRLWCNNVDGAHKGCRTQHTPWA-----DGTECEPGKHCKFGFCV------ 578

  Fly   633 GSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCL 697
                                                  |.:.|.|....:||.||....|...|
Mouse   579 --------------------------------------PKEMEGPAIDGSWGGWSHFGTCSRTC- 604

  Fly   698 YGQSRRLLEGSTGLRTLNRSCLNFP------SRCIGRDRRFVTCNTPQCHKVPVQTINDFATQVC 756
                      ..|::|..|.| |.|      ..|:||..:|.:|||..|.|..    .||..:.|
Mouse   605 ----------GGGIKTAIREC-NRPEPKNGGKYCVGRRMKFKSCNTEPCMKQK----RDFREEQC 654

  Fly   757 MQARKSDPELTGEGQQLPST----------LDASCKIFCRTRTNGTKSR-RWTFPDGTTCKAKQH 810
            .........:.|   .|||.          :...||:|||...|....: |....|||.|   ..
Mouse   655 AHFDGKHFNING---LLPSVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPC---GQ 713

  Fly   811 NPEDITYCISGRCERFSCD---NSTSNFFKM-----DSSFCE--ARSVRPTRDSSDQESRQQTNR 865
            :..||  |:.|.|.:..||   ||.:...|.     |:|.|:  |.:........:...|.....
Mouse   714 DTNDI--CVQGLCRQAGCDHILNSKARKDKCGICGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGA 776

  Fly   866 QRYAERQEGKPQKNHYENEVAKRPSYGQ----GNHINAPASPYKRR------------------- 907
            .....||.....|:..:|.:|...|.|:    |:.:   .|..||.
Mouse   777 TSIDVRQHSFSGKSEDDNYLALSNSKGEFLLNGDFV---VSMSKREVRVGSAVIEYSGSDNVVER 838

  Fly   908 ----------------NYHKPYPPE------IPRPPPPASASLIALDRSSSSESEWVAHPGCHSN 950
                            :..|.|.|:      ||....|             .:..|.:| |....
Mouse   839 LNCTDRIEEELLLQVLSVGKLYNPDVRYSFNIPIEDKP-------------QQFYWNSH-GPWQA 889

  Fly   951 CMTDSKGVQGVTSR--LTGVESIQLCSYRIQPCERLQTAAEYAEQT------------------- 994
            |   ||..||...|  :...||.|| :...|.|:||.......|..
Mouse   890 C---SKPCQGERRRKLVCTRESDQL-TVSDQRCDRLPQPGPVTEACGTDCDLRWHVASKSECSAQ 950

  Fly   995 -----------CARYRQKVRGLSGHGAQISASI--DEPDRSCRVGCQDEFIKYRYYLVNGRNGHF 1046
                       ||:|.:    :.|...::..|.  .:|..|.:..|..|
Mouse   951 CGLGYRTLDIHCAKYSR----MDGKTEKVDDSFCSSQPRPSNQEKCSGE---------------- 995

  Fly  1047 PPGTRCSPVGKRYCVYGRCLEFGDDDLPLDKTHISLGQLRTRRKRS---SISNDLFNITEIFIKP 1108
                 ||..|.||..:..|....|..              |:|:|:   :..||:.:.:    |.
Mouse   996 -----CSTGGWRYSAWTECSRSCDGG--------------TQRRRAICVNTRNDVLDDS----KC 1037

  Fly  1109 SHSD---ISAENIEFTQP 1123
            :|.:   :.:.| ||:.|
Mouse  1038 THQEKVVVQSCN-EFSCP 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	20/106 (19%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	56/217 (26%)
		Reprolysin	332..545	CDD:279729	57/218 (26%)
		TSP1	683..741	CDD:214559	19/63 (30%)
Adamts9	NP_780523.3	Pep_M12B_propep	49..207	CDD:334593	39/203 (19%)
		ZnMc_ADAMTS_like	293..496	CDD:239801	56/217 (26%)
		TSP1	591..642	CDD:214559	19/62 (31%)
		ADAM_spacer1	753..871	CDD:310520	16/120 (13%)
		TSP1	1001..1054	CDD:214559	14/71 (20%)
		TSP1	1055..1108	CDD:214559	262/1253 (21%)
		TSP1	1114..1166	CDD:214559
		TSP1	1186..1239	CDD:214559
		TSP1	1239..1296	CDD:214559
		TSP1	1328..1380	CDD:214559
		TSP1	1382..1436	CDD:214559
		TSP1	1441..1483	CDD:214559
		TSP1	1500..1551	CDD:214559
		TSP1	1560..1609	CDD:214559
		TSP1	1611..>1636	CDD:214559
		GON	1734..1930	CDD:337156
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810