DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and adamtsl2

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_021332354.1	Gene:	adamtsl2 / 100537087	ZFINID:	ZDB-GENE-070705-558	Length:	1012	Species:	Danio rerio

Alignment Length:	683	Identity:	138/683 - (20%)
Similarity:	218/683 - (31%)	Gaps:	193/683 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   597 RQDGLPWTS-HPALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEP- 659
            |...||.:| ....||.:.|.....|||. |....:...|...|:.|.....|.|| .:.:|:.
Zfish    14 RSPTLPLSSCRAGTEGKKGGRRRRRRGGG-EEGGCRSTPYPLYKTHPHSTPSETTH-TVQQHQLQ 76

  Fly   660 -------NRIPPLLHDYNPMDNEL---------PGSPSN------------WGEWSEPSACESGC 696
                   :||..:|.....:...|         .|..||            ||||::.:||...|
Zfish    77 LCRMKIWSRISLVLLGLVTLALSLGNLSSRGQEEGVASNSLEDGLEVITYWWGEWTKWTACTRTC 141

  Fly   697 LYGQSRRLLEGSTGLRTLNRSCLNFPSR---------CIGRDRRFVTCNTPQCHKVPVQTINDFA 752
                       ..|:.:..|.||....:         |.|..:::..||..:|    ..|...|.
Zfish   142 -----------GGGVMSQERHCLKQRKKTTTGKDNMTCTGNAKKYHLCNAKEC----PSTGRSFR 191

  Fly   753 TQVCMQARKS---------DPELTGEGQQLPSTLDASCKIFCRTRTNGTKSRRWTFPDGTTCKAK 808
            .:.|......         .|....:...:.|.   .|.:.| |.::|.:.......|||:||..
Zfish   192 EEQCWSFNSQVYNGKNYHWKPLYPDDYVHISSN---PCDLHC-TTSDGQRQLMVPARDGTSCKYS 252

  Fly   809 QHNPEDITYCISGRCERFSCDN---STSNFFKM-----DSSFCE---------ARSVRPTRDSSD 856
            .:.    ..|:.|:||...||.   |.:...|.     |.|.|.         |.|:..|..:..
Zfish   253 NYR----GVCVDGKCEPIGCDGVLFSPNTLDKCGVCQGDGSSCSRVTGNFRRGASSLGYTFITQI 313

  Fly   857 QESR---QQTNRQRYAE-----RQEGK-----------PQKNHYENEVAK--RPS--YGQGNHIN 898
            .|..   |...|::.|:     .|.|.           ||..|....:.|  ||:  |..|....
Zfish   314 PEGSWDIQVIERKKSADILAVTDQAGNFFFNGAYKMDTPQNFHAAGTIFKYRRPTDVYETGIEYI 378

  Fly   899 APASPYKR--------RNYHKPY-----------PPEIPRPP----PPASASLIALDRSSSSESE 940
            ....|..:        :|...||           ...:.:||    |...:||::::..|..:
Zfish   379 VAKGPIDQPINVLVWNQNGQNPYITYEYTVMRDSMASVSQPPIYTGPQGGSSLVSVEVVSVLQ-- 441

  Fly   941 WVAHPGCHSNCMTD-----SKGVQGVTSRLTGVESIQLCSYRIQPCER-LQTAAEYAEQTCARYR 999
                   |:..|.|     :.|.:.|..:....|:.::.......||: ..|..:|.|..|:
Zfish   442 -------HNQSMYDKNQEQTTGPRAVEGQKPAQETNEVYETANIDCEQDANTQVQYTEGNCS--- 496

  Fly  1000 QKVRGLSGHGAQISASIDEPDRSC--------------RVGCQDEFIKY-RYYLVNGRNGHFPPG 1049
                ..|..||..:|::..|....              |:|........ ...|:..|:|   ..
Zfish   497 ----WPSAVGAPGTATVSRPAEDMVNSENLIWRVLLGERLGSDGVLANISTNQLLTHRDG---LS 554

  Fly  1050 TRCSPVGKRYC------VYGRCLEF------GDDDLPLDKTHISLGQLRTRRKRSSISNDLFNIT 1102
            :...|:...|.      :.|..|||      .|.||.|...::: ..||.|..|:..::.|....
Zfish   555 SEAEPMELDYSSLEQAGLNGSLLEFTLGNRRNDTDLLLPNRNLT-AILRNRGNRTRNNHRLLQKN 618

  Fly  1103 EIFIKPSHSDISAENIEFTQPIHVSADELSSKS 1135
                |||.:|:....:...:|..::.....|||
Zfish   619 ----KPSAADMYRWKLSTQEPCSMTCSIGVSKS 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848
		ZnMc_ADAMTS_like	331..543	CDD:239801
		Reprolysin	332..545	CDD:279729
		TSP1	683..741	CDD:214559	15/66 (23%)
adamtsl2	XP_021332354.1	TSP1	128..184	CDD:214559	16/70 (23%)
		ADAM_spacer1	294..409	CDD:310520	21/114 (18%)
		TSP1	686..745	CDD:214559
		TSP1	919..968	CDD:214559
		PLAC	976..1007	CDD:312271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900