DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and adamts3

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_012810820.2	Gene:	adamts3 / 100498276	XenbaseID:	XB-GENE-490472	Length:	1199	Species:	Xenopus tropicalis

Alignment Length:	754	Identity:	186/754 - (24%)
Similarity:	281/754 - (37%)	Gaps:	194/754 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 SPAAALDLCEPGNVRGVFQQNGSDLVIHPLPARFGTGTHVLYQARVDKSGGGYSEASSRRTASPL 263
            ||.|.:.|.....:.|:.:....:..|.||..          ..:.|:..|.......|.||..:
Frog   156 SPGALVALSNCDGLAGMIRTKEDEYFIEPLER----------GKQKDEENGRLHVVYKRSTAKQI 210

  Fly   264 DSQLQFEPDAEEFNEPRRR---------LRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDA 319
            .:     .|:..|:|....         ...:.|:...|                 ||||:.|:
Frog   211 PT-----GDSHNFSEADFAGLDNVDSIFSNIEKQVNETL-----------------RRRRHAGE- 252

  Fly   320 PRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRIN 384
                     .:..||..:.||..:.....|       ..|.::||.::|.|..:||..::|..||
Frog   253 ---------NDYNIEVLLGVDDSVVRFHGK-------EHVQNYLLTLMNIVNEIYHDDSIGVHIN 301

  Fly   385 FVLKRLEIWKSWDPPGLVRSRDVENYLNSFCKW---QEKLNPFSDADPLHYDHALVLTGLDLVTY 446
            .||.|:.:........|:........|::.|:|   |:|.:|....   |:|||:.||..|.
Frog   302 IVLVRMIMLGYAKSISLIERGSPSRSLDNVCRWASQQQKADPNHSE---HHDHAIFLTRQDF--- 360

  Fly   447 DKGKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISC-DPTM-- 508
              |.|..|  |.|.|.|||..:.|||:|....|.|.||||||.||.|||.||.:...| |.|.
Frog   361 --GPAGMQ--GYAPVTGMCHPMRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMG 421

  Fly   509 HIMSPKLGSG--KVTWSKCS----RTYLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNA 567
            .:|:|.:.:.  :..||:||    :.|:..:      :||.| |.|...|.....  |||..::.
Frog   422 SVMAPLVQAAFHRYHWSRCSGQELKRYIHSY------DCLLD-DPFEHDWPKLPD--LPGINYSM 477

  Fly   568 NQQCMLRFGKNFMQASTQSKMEICRDLHCRQDGLPW----TSHPALEGTECGPNMWCRGGTCEAR 628
            ::||...||..:...:.....|.|:.|.|.....|:    ...|.|:||||.|..||..|.|..:
Frog   478 DEQCRFDFGVGYKMCTAFRTFEPCKQLWCNHPDNPYFCKTKKGPPLDGTECAPGKWCYKGHCMWK 542

  Fly   629 SSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACE 693
            ::.|                      ::.:                      .|||.|::..:|.
Frog   543 TTNQ----------------------VKQD----------------------GNWGSWTKFGSCS 563

  Fly   694 SGCLYGQSRRLLEGSTGLRTLNRSC-----LNFPSRCIGRDRRFVTCNTPQCHKVPVQTINDFAT 753
            ..|           ..|:|...|.|     :|....|.|.:..:..|||.:|.|    ...||..
Frog   564 RTC-----------GIGVRFRTRQCNNPMPVNGGQDCSGLNYEYQLCNTEECPK----HFEDFRA 613

  Fly   754 QVCMQARKSDPELTGEGQQLP-STLDAS--CKIFCRTRTNGT-KSRRWTFPDGTTCKAKQHNPED 814
            |.|.|...:......:...|| ...||:  |:::|:::..|: .|.:....|||.|..|  :|..
Frog   614 QQCQQRNSNFEYQNAKHHWLPYEHPDANKRCQLYCQSKETGSIASMKQLVHDGTRCSYK--DPHS 676

  Fly   815 ITYCISGRCERFSCDNST-SNFFKMDS--SFC-----EARSVRPTRDSSDQESR-------QQTN 864
            |  |:.|.|.:..||... ||  |:|.  ..|     ..|:|:.|...:.::|.       ....
Frog   677 I--CVRGECIKVGCDKEIGSN--KVDDKCGVCGGDNAHCRTVKGTFTRTPKKSGYLKMFDIPPGA 737

  Fly   865 RQRYAERQEGKPQ----KN----HY----ENEVAKRPSY 891
            |..:.:..|..|.    ||    ||    :.|.||..|:
Frog   738 RHVFIQEDEASPHVLAIKNQATGHYILNGKGEEAKSRSF 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	8/39 (21%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	71/223 (32%)
		Reprolysin	332..545	CDD:279729	72/224 (32%)
		TSP1	683..741	CDD:214559	15/62 (24%)
adamts3	XP_012810820.2	Pep_M12B_propep	44..202	CDD:396235	10/55 (18%)
		ZnMc_ADAMTS_like	255..456	CDD:239801	71/223 (32%)
		ADAM_CR_2	471..539	CDD:407643	21/67 (31%)
		TSP1	553..605	CDD:214559	15/62 (24%)
		ADAM_spacer1	712..826	CDD:368694	15/65 (23%)
		TSP1_ADAMTS	848..903	CDD:408800
		TSP1_ADAMTS	908..965	CDD:408800
		TSP1_ADAMTS	969..1014	CDD:408800
		PLAC	1022..1050	CDD:400844
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910