Protein Alignment stl and adamts19

DIOPT Version :10

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: XP_031748801.1
• Gene: adamts19 / 100494209
• XenbaseID: XB-GENE-980450
• Length: 1205
• Species: Xenopus tropicalis
• Alignment Length: 1326
• Identity: 276/1326 - (20%)
• Similarity: 427/1326 - (32%)
• Gaps: 412/1326 - (31%)

  Fly    22 LWLLIGASSSSSST----------------------SSTNPKSVNIELRRKRSLHYNGIELDKNT 64
            |:||:...||.|||                      .|.|||    |..||..:.......|:|.
 Frog    16 LYLLLCIMSSKSSTDKGLMNTTQWYEEWEVVYPALWGSQNPK----EEERKALVSSGTPSTDRNH 76

  Fly    65 LVGHLREHERALIFGSR------SPEEAPEFKLVHLAQQRPEEQQRLEERKRPGEAEQHGGNPHQ 123
            ...|...........||      ||.....:  .||:|:..:|.:|.|.:.. ....|......:
 Frog    77 SNIHSSSSYNQAAVSSREVRSVSSPSTTSTY--YHLSQEEEQENERFEPQDM-YHLSQFSWISKE 138

  Fly   124 RRQRRSLPSEDGNGPLPPE-----------EEEQEAGE--------DVEARLQLQQSPQLIDDAF 169
            :....|.|    |..:|..           ::.:.||:        .:|..|.|::....:...|
 Frog   139 KTTNASSP----NASIPVSVLSSGKSITSLKQSENAGKMRLKIPVFGLELYLLLKRDNHFLAPGF 199

  Fly   170 IFIRRTENGTQFVEHSPQLLKRLERCFY-----RSPAAALDLCEPGNVRGVFQQNGSDLVIHPLP 229
            :..:|..   ::...|.|...|  .|:|     |.|.:.......|.:.|..|.|...:.|.||.
 Frog   200 VVEQRHR---EWRGSSVQDTDR--ECYYSGTVLRHPGSFASFSTCGGLMGFIQMNEDFIYIEPLN 259

  Fly   230 ARFGTGTHV--LYQARVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSP 292
            .......|.  :|:.:.......:.:.|:.:.:..:..              |||.|......:
 Frog   260 QTMAVAGHAHRVYRRKRATENKSWEKKSNHQPSCGITD--------------RRRTRNYKASDT- 309

  Fly   293 LRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTES 357
                             .|.:||....        .::..|||.:..|..:.::   :.|..|.
 Frog   310 -----------------GRGKRYSFKQ--------AQQYNIETVVVADPAMVSY---HGPEATR- 345

  Fly   358 KVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQEKLN 422
               .|:|.::|.|..|:.|.:||.::|..:.:|.:... .|..:......|..|.||||||  |.
 Frog   346 ---KFILTILNMVYNLFQHKSLGVQMNLRVTKLVLLHE-SPVDMYIGHHGEKMLESFCKWQ--LE 404

  Fly   423 PFSDADPLH-------------YDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTIN 474
            .|...:.:|             .|.|:::|..|...:.....::  ||:|.:.|||:....|.|.
 Frog   405 EFGKKNDVHMEMSTSWGEEYSAVDAAILITRTDFCVHKDEPCDT--VGIAYLNGMCSDKRKCIIA 467

  Fly   475 EAKHFESVFVVAHEIGHNLGMRHDAKEISCDPTMHIMSPK----LGSGKVTWSKCSRTYLEDFLM 535
            |.......|.:|||:|||:|:.||....||...:||||.:    ...|.|:||:|||..||.||.
 Frog   468 EDNGLNLAFTIAHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSREDLERFLR 532

  Fly   536 DPQAECLFDRDSFAGPWDHTAG---GRLPGERFNANQQCMLRFGKNFMQASTQSKME--ICRDLH 595
            ...:.||..    ..|...::|   .::||..:.|::||.:.||.   .||...:|:  ||..|.
 Frog   533 SKASNCLLQ----TNPQSLSSGIIPSKVPGMTYTADEQCQILFGP---AASFCEEMQHVICTGLW 590

  Fly   596 CRQDG---LPWTSHPALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRH 657
            |:.||   ......|.::||.||...||..|.|.:.:|.           .||:.
 Frog   591 CKLDGEKECKTNLDPPMDGTRCGLEKWCTAGECTSIASS-----------AEHLS---------- 634

  Fly   658 EPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCL--- 719
                                      ||||....|...|           |||:.:..|.|.
 Frog   635 --------------------------GEWSSWGTCSRTC-----------STGISSRQRKCQSQG 662

  Fly   720 NFPSRCIGRDRRFVTCNTPQCHKVPVQTIN-------DFATQVCMQARKSDPELTGEGQQLPSTL 777
            |...:|.....:...|..|:|   |..|.|       .|:.:...|..|         .|..|.:
 Frog   663 NEGRQCNDPKIQHRICENPEC---PANTPNFRDWQCQTFSFRTSYQKNK---------HQWQSII 715

  Fly   778 --DASCKIFCRTRTNGTKSRRWTFP--------DGTTCKAKQHNPEDITYCISGRCERFSCDNST 832
              :..|.:||.......       |        |||.|   ..|..||  |.:|||::..||...
 Frog   716 NEEKPCALFCSALGKDQ-------PILVAEKVLDGTPC---GQNGLDI--CSNGRCQKVGCDGIL 768

  Fly   833 SNFFKMD------------------------SSFCEARSVRPTRDSSDQESRQQTNRQRYAERQE 873
            .:..:.|                        :.:.|| .|.||.....:...:.......|.|..
 Frog   769 GSLSREDHCGVCNGNGKSCKVIKGDFNHTKGAGYVEA-LVIPTGARRIKVVEEMPAHSYLALRDA 832

  Fly   874 GKPQKN------------------HY------ENEVAKRPSYGQGNHINAPASP-------YKRR 907
            .|...|                  ||      |...||.|:          .||       :..:
 Frog   833 SKHSFNDDWKIEDPGTFHLAGTTVHYIRRGLWEKISAKGPT----------TSPLHLLVLLFHDQ 887

  Fly   908 NYHKPYPPEIPRPPPPASASLIALDRSSSSESEWVAHPG---CHSNC-----MTDSKGVQGVTSR 964
            ||...|...||....|.:    .:.|::.....| .|.|   |.:.|     .|.....:.:...
 Frog   888 NYGLHYEYTIPLESVPGN----RIGRTNEPLYMW-THSGWEDCDAVCGGGERKTTVTCTKIMNKN 947

  Fly   965 LTGVES------------IQLCSYRIQPCER--LQTAAEYAEQTCARYRQ--------------- 1000
            :|.|.:            |:.|:.  |||:.  :.|......:||.:..|
 Frog   948 ITNVHNKHCKDLTKPDPQIRKCNE--QPCQTRWMMTDWTPCSKTCGKGTQSRQTTCTKQLRNGTL 1010

  Fly  1001 ---KVRGLSGHGAQISASIDEPD----------RSCRVGCQDEFIKYRYYLVNGRNGHFPPGTRC 1052
               :.|..:||....|...:..|          ..|.:.| .:.:::|  .:...|    |..:|
 Frog  1011 ISVQERDCAGHKPASSQRCEGQDCMTVWEAGVWSECSLKC-GKGVRHR--TIKCTN----PRKKC 1068

  Fly  1053 ----SPVGKRYCV-YGRCLEFGDDDLPLDKTHISLGQLRTRRKRSSISNDLFNIT-----EIF-- 1105
                .|.....|. |.||..:...|  ..|..::.|    :..:|.:...:..||     |.|
 Frog  1069 LLSTRPKEMEDCEDYSRCYIWRTGD--WSKCSVTCG----KGMQSRVIQCMHKITGRHGNECFSS 1127

  Fly  1106 -----IKPSHSDISAENIE---FTQP 1123
                 .:|.|..:..|.:.   .|.|
 Frog  1128 EKPAAYRPCHQHVCNEKVNVNTITSP 1153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	69/228 (30%)
		ADAMTS_CR_2	561..625	CDD:465496	24/68 (35%)
		TSP1	683..741	CDD:214559	15/60 (25%)
adamts19	XP_031748801.1	Pep_M12B_propep	150..272	CDD:460254	23/126 (18%)
		ZnMc_ADAMTS_like	323..540	CDD:239801	69/228 (30%)
		ADAMTS_CR_2	557..624	CDD:465496	24/69 (35%)
		TSP1	635..684	CDD:214559	16/62 (26%)
		ADAMTS_CR_3	<721..787	CDD:437068	18/77 (23%)
		ADAMTS_spacer1	789..898	CDD:461796	20/119 (17%)
		TSP1_ADAMTS	922..974	CDD:465950	8/53 (15%)
		TSP1_ADAMTS	978..1034	CDD:465950	8/55 (15%)
		TSP1_ADAMTS	1038..1080	CDD:465950	7/48 (15%)
		TSP1_ADAMTS	1089..1141	CDD:465950	10/57 (18%)