DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and adamtsl3

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_012814972.2	Gene:	adamtsl3 / 100493011	XenbaseID:	XB-GENE-923351	Length:	1777	Species:	Xenopus tropicalis

Alignment Length:	605	Identity:	124/605 - (20%)
Similarity:	189/605 - (31%)	Gaps:	217/605 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   630 SKQGSYSALKSWPPEHIPEATHEKIIRH----EPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPS 690
            |.|||:          :.:.|.|:.:.:    :.:||       ...|::.......||.||:
Frog    52 SPQGSF----------LEDTTGEQFLTYRYDDQTSRI-------TRSDDDKDNGWDAWGTWSD-- 97

  Fly   691 ACESGCLYGQSRRLLEGSTGLRTLNRSCLNFPSRCIGRDRRFVTCNTPQCHKVPVQTINDFATQV 755
             |...|..|.|..|           |.|||..| |.||:.|:.||:...|    ...:.||..|.
Frog    98 -CSRTCGGGASYSL-----------RRCLNGRS-CEGRNIRYKTCSNNDC----PSDVGDFRAQQ 145

  Fly   756 CMQARKSDPELTG---EGQQLPSTLDASCKIFCR-TRTNGTKSRRWTFPDGTTCKAKQHNPEDIT 816
            |  :..:|.:..|   |.|.:.:...|.|.:.|: ...|..........|||.|     |.:...
Frog   146 C--SAHNDVKYQGQYYEWQPVYNDASAPCALKCQAVGKNLVVELAPKVLDGTRC-----NTDSPD 203

  Fly   817 YCISGRCERFSCDNSTSNFFKMDS--------SFCEARSVR-PTRDSSDQESRQQT-----NRQR 867
            .||||.|:...||....:..|.|:        |.|  |.|| .||.....|.|::|     :..|
Frog   204 MCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTC--RLVRGQTRSHLSPEKREETIIAVPHGSR 266

  Fly   868 ------------YAERQ--EGKPQKNHY-------------------ENEVAKRP---------- 889
                        :.|.:  :|:..::.:                   |.|:.|.|
Frog   267 SVRITVKGPAHVFIESKTLQGESGEHSFTSPGSYVIENTTVEFQRGSEREILKIPGPLRADFIIK 331

  Fly   890 ---------------------------------SYGQGNHINAPASPYKRRN-----YHKPYPPE 916
                                             :.|.|..:|:......|.|     ::..|.||
Frog   332 IKYAAPKDSIVQFYFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLNRTVNDHYCHYYPE 396

  Fly   917 IPRPPPPASASLIALDRSSSSESE------------WVAHP--GCHSNCMTDSKGVQG-----VT 962
            ..:|.|......:....||....|            |..:|  .|..:|   ..|:|.     |.
Frog   397 NKKPKPKLKECNMEPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSC---GGGIQRRSIVCVE 458

  Fly   963 SRLTGVESIQL----CSYRIQPCERLQTAAEYAEQTCARYRQKVRGLSGHGAQISASIDEPD--- 1020
            ..:.| |.:|:    |.|..:|.         ..|||..:                  |.|.
Frog   459 ETMHG-EILQVEEWKCMYAPKPT---------IMQTCNLF------------------DCPKWMA 495

  Fly  1021 ---RSCRVGCQDEFIKYRYYLVNGRNGHFPPGTRCSPVGKRY----CVYG-RCLEFGDDDLPLDK 1077
               ..|.|.| ...::||..|.|...|....|  |:|..|.:    ||.. .|.: ..:..|::.
Frog   496 MEWSQCTVTC-GRGLRYRVVLCNDHRGQHTGG--CNPQLKPHIKEECVVPVPCFK-PRERFPVEA 556

  Fly  1078 THISLGQLRTRRKRSSISND 1097
            .|..|.|.:...:..:.|::
Frog   557 KHPWLKQAQELEETKTASDE 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848
		ZnMc_ADAMTS_like	331..543	CDD:239801
		Reprolysin	332..545	CDD:279729
		TSP1	683..741	CDD:214559	20/57 (35%)
adamtsl3	XP_012814972.2	TSP1	89..135	CDD:214559	21/64 (33%)
		TSP1_ADAMTS	354..412	CDD:408800	10/57 (18%)
		TSP1_ADAMTS	433..490	CDD:408800	16/87 (18%)
		TSP1_ADAMTS	493..545	CDD:408800	14/54 (26%)
		TSP1_ADAMTS	579..636	CDD:408800
		TSP1_ADAMTS	718..771	CDD:408800
		TSP1_ADAMTS	775..831	CDD:408800
		TSP1_ADAMTS	837..892	CDD:408800
		Ig	943..999	CDD:416386
		Ig strand C	955..960	CDD:409353
		Ig strand C'	962..965	CDD:409353
		Ig strand D	970..974	CDD:409353
		Ig strand E	977..983	CDD:409353
		Ig strand F	990..998	CDD:409353
		Ig	1216..1285	CDD:416386
		Ig strand B	1216..1225	CDD:409353
		Ig strand C	1231..1235	CDD:409353
		Ig strand C'	1238..1240	CDD:409353
		Ig strand D	1248..1252	CDD:409353
		Ig strand E	1253..1258	CDD:409353
		Ig strand F	1266..1274	CDD:409353
		Ig	1318..1382	CDD:416386
		Ig strand B	1322..1329	CDD:409353
		Ig strand C	1337..1341	CDD:409353
		Ig strand D	1353..1356	CDD:409353
		Ig strand E	1357..1362	CDD:409353
		Ig strand F	1370..1378	CDD:409353
		Ig_3	1416..1489	CDD:404760
		Ig strand C	1443..1447	CDD:409353
		Ig strand E	1468..1472	CDD:409353
		Ig strand F	1482..1487	CDD:409353
		TSP1_ADAMTS	1508..1562	CDD:408800
		TSP1_ADAMTS	1566..1623	CDD:408800
		TSP1_ADAMTS	1626..1682	CDD:408800
		TSP1_ADAMTS	1686..1740	CDD:408800
		PLAC	1745..1774	CDD:400844
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910