DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and adamts13

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_031747422.1	Gene:	adamts13 / 100485801	XenbaseID:	XB-GENE-6038835	Length:	1593	Species:	Xenopus tropicalis

Alignment Length:	1147	Identity:	253/1147 - (22%)
Similarity:	382/1147 - (33%)	Gaps:	410/1147 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LWLLIGASSSSSSTSSTNPKSVNIELRRKRSLHYNGIELDKNTLVGHLREHERALIFGSRSPEEA 86
            ||:.:|...|.            :....|:.||:    |:...|.|:         ||:.|..|:
Frog     7 LWVALGLLLSP------------VLCATKKFLHH----LEPEELYGY---------FGATSVLES 46

  Fly    87 PEFKLVHLAQ-----QRPEEQQRLEERKRPGEAEQHGGNPHQRRQRRSLPSEDGNGPLPPEEEEQ 146
               .:|.||:     :.||                                      |||
Frog    47 ---NVVDLAELTCSCESPE--------------------------------------LPP----- 65

  Fly   147 EAGEDVEARLQLQQSPQLIDDAFIFIRRTENG----TQFVEHSPQLLKRL-ERC----FYRSP-- 200
                   ..|.|:...|..:..|:|.....:|    .:.|..|.|.||.. |.|    |...|
Frog    66 -------LCLALRCILQGTEGTFVFRFPVGSGPIITERVVNTSLQRLKHFPEGCGVPGFILYPDE 123

  Fly   201 -AAALDLCEPGNVRGVFQQNGSDLVIHPLPARF-----GTGTHVLYQARVDKSGGGYSEASSRRT 259
             .|.:..|| |.:||....:|..|.|.||..|.     ...:|::  :||.||    ..||....
Frog   124 TKAVISYCE-GELRGFIVSDGHLLSIQPLKKRHEQDHKSRSSHII--SRVGKS----PPASGGPR 181

  Fly   260 ASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRW 324
            .:||.:::.                                            :|.:|....
Frog   182 PAPLPNRIS--------------------------------------------KRAVGGVKH--- 199

  Fly   325 SDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMIN-GVQLLYHHPTLGRRINFVLK 388
                    :|..:.|..|:|...|:    :||    .::|..:| ||:|| ...:||......|.
Frog   200 --------LELLVVVGHDVYQFHQE----DTE----RYVLTNLNIGVELL-RDVSLGTAFRVHLV 247

  Fly   389 RLEIWKSWDPPGLVR-SRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKAN 452
            :|.|..  :|...:: :.::.:.|.|.|||..|:||..|:||.|.|..|.:|..||...|   .|
Frog   248 KLIILT--EPEADIQITTNLTSSLISLCKWSHKVNPPDDSDPQHADLVLYVTRFDLELPD---GN 307

  Fly   453 SQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPTMHIMSPKLGS 517
            .||.|:..:.|.|:|::||.|.|...|:....:||||||:.|:.||....||..:.:||:.:...
Frog   308 KQVRGVTQLGGACSSVWSCVITEDTGFDLGVTMAHEIGHSFGINHDGTGNSCSKSGNIMASEGYH 372

  Fly   518 GKV--TWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFM 580
            ..|  |||:|||.....||....|.|:.|..:.    |.:..|..||..:.|::||.:.||.:.:
Frog   373 NNVHLTWSECSREQFLRFLSSGMASCVDDLPAM----DSSIPGWKPGLYYGADEQCQIAFGSSAL 433

  Fly   581 QAS-TQSKMEICRDLHCRQDGLPWTS-----HPALEGTECGPNMWCRGGTCEARSSKQGSYSALK 639
            ..: :::.::.|..|.|..:....||     .|.|:|||||.|.||..|.|.:
Frog   434 ACTFSRNDLDSCSVLSCHINQHDRTSCNRLLVPLLDGTECGENKWCHKGRCSS------------ 486

  Fly   640 SWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRL 704
                                      |.:.||:.....|    |..|...|:|...|
Frog   487 --------------------------LEELNPVSVVHGG----WSSWGSFSSCSRSC-------- 513

  Fly   705 LEGSTGLRTLNRSCLN----FPSR-CIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSDP 764
               ..|:....|.|.|    |..| |.|.:.:...|||..|....:..:|:       |...:|.
Frog   514 ---GGGVVMRKRQCNNPRPAFGGRACEGSNLQAEMCNTQVCSSTQIGFMNE-------QCSDTDT 568

  Fly   765 ELTGEGQQLPSTL-----------DASCKIFCRTRTNG-TKSRRWTFPDGTTCKAKQHNPEDITY 817
            :.......:||..           .|.|:..||.:... ..:|..:|.|||.|:..:.....:..
Frog   569 KPLYLSPGIPSFYKWTSAVGFVDGKALCQYMCRAQGKSFIVARGKSFLDGTRCETNKEANAKLGL 633

  Fly   818 CISGRCERFSC------------------DNSTSNFFKMDSSFCEARS-------VRPTRDSSDQ 857
            |::|.|..|.|                  ||||.|  ::..||.|.::       ..|...:|.:
Frog   634 CVAGSCRVFGCDGVMGSGMVKDQCGVCGGDNSTCN--RIHGSFSEGKAGEYVSFLTLPPGSTSLK 696

  Fly   858 ESRQ-----------------------------------QTNRQRYAERQEGKP--QKNHYENEV 885
            .:.|                                   ||...|.....:..|  ::.|.|...
Frog   697 VTNQKPVFTHLGIKVNDEYLVAGKGSISLNVTYPSVLEDQTIEYRLFLNADKLPHLEQIHIEGPT 761

  Fly   886 AKR------PSYGQ--GNHINAPASPYKRRNYHKP--------YPPEIPRPPPPASAS------L 928
            .|.      ..|||  |:..| |...|   :||.|        :|     .|.|.|||      |
Frog   762 TKELEIQVYRKYGQEYGDATN-PDIIY---SYHIPKKDIEYKWFP-----VPGPCSASCDGGFHL 817

  Fly   929 IALDRSSSSESEWVAHPGCH--------------------------SNCMTDSKGVQGVTSRL-- 965
            ::.:.|....::.|....|:                          |.|.....|  ||..|.
Frog   818 VSYECSEHDLNQLVQSSLCNDSARPSSFHEPCGIDPCPPRWDVKESSPCTVSCGG--GVVLRTLH 880

  Fly   966 -----TGVESIQLCSY-------------RIQPCERLQTAAE 989
                 .|:|:|...:|             .::||.....|:|
Frog   881 CVQMQQGIETILFDAYCDHSTRPEAFVACGLEPCPARWEASE 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	28/100 (28%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	73/215 (34%)
		Reprolysin	332..545	CDD:279729	73/216 (34%)
		TSP1	683..741	CDD:214559	16/62 (26%)
adamts13	XP_031747422.1	Pep_M12B_propep	<99..167	CDD:396235	21/68 (31%)
		ZnMc_ADAMTS_like	198..400	CDD:239801	73/226 (32%)
		ADAM_CR_2	414..484	CDD:407643	23/69 (33%)
		TSP1	<511..552	CDD:214559	12/51 (24%)
		ADAM_spacer1	670..792	CDD:368694	22/125 (18%)
		TSP1_ADAMTS	800..854	CDD:408800	10/58 (17%)
		TSP1_ADAMTS	858..914	CDD:408800	10/57 (18%)
		TSP1_ADAMTS	918..974	CDD:408800	2/5 (40%)
		TSP1_ADAMTS	1012..1061	CDD:408800
		TSP1_ADAMTS	1065..1121	CDD:408800
		TSP1_ADAMTS	1125..1183	CDD:408800
		TSP1_ADAMTS	1187..1243	CDD:408800
		TSP1_ADAMTS	1247..1301	CDD:408800
		CUB	1471..1579	CDD:412131
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910