Protein Alignment stl and adamts12

DIOPT Version :10

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: XP_017946319.2
• Gene: adamts12 / 100380018
• XenbaseID: XB-GENE-959575
• Length: 1569
• Species: Xenopus tropicalis
• Alignment Length: 1250
• Identity: 267/1250 - (21%)
• Similarity: 413/1250 - (33%)
• Gaps: 410/1250 - (32%)

  Fly   117 HGGNPH-----QRRQRRSLP-----------SEDGN---GPLPPEEEEQEAGEDVEARL------ 156
            |..|||     |.....|||           .|.||   ..|....:...|.:.:..|:
 Frog    42 HRDNPHSLHKGQEHLDHSLPLAFEVVEPVKVDEKGNFLSYNLQHRRKRSVASQAIHYRIHHKTHN 106

  Fly   157 ---QLQQSPQLIDDAFIFIRRTENGTQFVEHSPQLLKRLERCFYRSPAAALDLCEPGNVRGVFQQ 218
               .|......:.|.||..||..|.:. ...||||
 Frog   107 LFFNLTFRDGFLSDNFILERRNGNSSH-ARISPQL------------------------------ 140

  Fly   219 NGSDLVIHPLPARFGTGTHVLYQARVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPRRRL 283
                          |.|.|::..|:....|||.:..|   ..:.|....:. ||.:.|.||   .
 Frog   141 --------------GNGCHLIGTAQRAHVGGGVAAIS---VCNGLAGFFRL-PDGDYFIEP---F 184

  Fly   284 RAQSQLQSPLRLRFQPRHHHPHQH--------HQQRRRRYI--GD---------------APRSR 323
            ...:|:..           .||||        |:.||...|  ||               ..|..
 Frog   185 HGATQVSG-----------KPHQHIIYQRDSPHRNRRELPISTGDFCAVNDNSKSVLQQERQREE 238

  Fly   324 WS------------DIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHH 376
            |.            .:.:|.::||.:..|:.:.|:...|       .|.|::..::|.|..|:|.
 Frog   239 WERKHLNGRKISQRSVSKERWVETLVVADTKMIAYHGSN-------NVESYIFTIMNMVTGLFHD 296

  Fly   377 PTLGRRINFVLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGL 441
            |.:|..|:..:.||.:.:. :..||....:.:..|.||||||:.:||.|||.|.|:|.|::||..
 Frog   297 PNIGNAIHIKVVRLILLEE-EEEGLKIVHNADQTLASFCKWQKSINPKSDAHPAHHDVAVLLTRK 360

  Fly   442 DLVTYDKGKANS--QVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISC 504
            |:.    ...||  :.:|::.:.|||....||.|||.......|.:|||:||:.|::||.:...|
 Frog   361 DIC----ASKNSPCETLGLSHLSGMCQPSKSCNINEDTGLPLAFTIAHELGHSFGIQHDGQGNDC 421

  Fly   505 D---PTMHIMSPKL--GSGKVTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGER 564
            :   ...:|||.:|  .:..:|||.||:.|:..||......||   |......|.......||..
 Frog   422 EIAGRNPYIMSRQLQYNTSPLTWSPCSKEYITRFLDRGWGFCL---DDVPAKKDLKPPIIAPGVL 483

  Fly   565 FNANQQCMLRFGKNFMQASTQSKME-ICRDLHCR-QDGLPWTSHPALEGTECGPNMWCRGGTCEA 627
            ::.|.||.|::|.|   |:...::: :|:.|.|. ::........|.:||.||.:.||..|.|
 Frog   484 YDVNHQCQLQYGPN---ATFCEEVDNVCQTLWCSVKNSCRSKLDSAADGTRCGESKWCFNGKC-- 543

  Fly   628 RSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSAC 692
                              |...|..:.|.                        ..||.|:..|.|
 Frog   544 ------------------INVGTTPQTIN------------------------GGWGAWTPWSHC 566

  Fly   693 ESGCLYGQSRRLLEGSTGLRTLNRSCLN----FPSR-CIGRDRRFVTCNTPQCHKVPVQTINDFA 752
            ...|           ..|.....|.|.|    |..: |.|..:|:..||...|.|       |:.
 Frog   567 SRTC-----------GAGAENAERKCNNPQPKFGGKYCTGERKRYRICNIQPCPK-------DYP 613

  Fly   753 TQVCMQARKSD--PELTGEGQQLP-STLDASCKIFCRTRTNGTKSRRW--TFPDGTTCKAKQHNP 812
            :...||..:.:  |......|.:| ...:..|::.||: ::|..:.::  ...|||.| .:::..
 Frog   614 SFREMQCTEFNTVPYKNELYQWIPIYNTENPCELHCRS-SSGNFANKFLDAVIDGTPC-FERNKS 676

  Fly   813 EDITYCISGRCERFSCD-----NSTSNFFKM---DSSFCEA-RSV----------------RPTR 852
            .|:  ||:|.|::..||     |:|.:...:   |.|.|:. :.|                :..|
 Frog   677 RDV--CINGICKKVGCDYEIDSNATEDRCGICLGDGSSCQTIKKVFNQTDGFGYVDVGLIPKGAR 739

  Fly   853 DSSDQESRQQTNRQRYAERQEGKPQKN------------------HYE--NEVAKRPSYGQGNH- 896
            |...:|..:..|.........||...|                  ||:  |:.....:.|..|.
 Frog   740 DIKIEEVEEAGNFLALRSEDPGKYYLNGAYIIQWNGEYKVAGTIFHYQRNNDTENITASGPTNES 804

  Fly   897 -----INAPASPYKRRNYHKPYPPEIPRPPPPASASLIALDRSSSSESE---------WVAHPGC 947
                 :....:|..|..|                  :|..|.:..:|.|         |.   .|
 Frog   805 IWIQLLFQEHNPGVRYEY------------------VIQKDVNLENEIESVYTWRYGGWT---DC 848

  Fly   948 HSNCMTDSKGVQGVTSRLT----GVESIQLCSYRIQPCERLQTAA-------------EYAEQTC 995
            .:.|.|   |||...||..    ||.....|...:||..|.:...             :....||
 Frog   849 SATCGT---GVQHQISRCVNKKRGVVKNTFCDQEMQPITRQKKCNTKECPPRWWVGQWQQCSTTC 910

  Fly   996 ARYRQKVRGL-----SGHGAQISASID-----EPD--------------------RSCRVGCQDE 1030
            ....:|.|.:     ||...:...|.|     :|.                    ..|.|.|...
 Frog   911 GPTGEKKRTVLCLKTSGSDEEALRSEDCHHLTKPKVYLSCNRDILCPSDWTVSNWSECSVTCGGG 975

  Fly  1031 FIKYRYYLVNGRNGHFPPGTRCSPVGKRYCVYGRCL---------------------EFGDDD-- 1072
             ::.| .:...:|...|..:...|..|..|...:|.                     :.||..
 Frog   976 -VRTR-NITCAKNNDEPCDSSKKPNSKALCGLQQCYVQKTLPKPPIKYNYRKKIIKKKSGDPKRR 1038

  Fly  1073 --LPLDKTH----------ISLGQLRTRRKRSSIS--------NDLFNITEIFIKPSHSDISAEN 1117
              || :|.|          :.:....|.....|:.        |::.|.|...|...::.:..||
 Frog  1039 IFLP-NKNHRVQTTTGLPRVFMSTSSTNSSSPSVKSIKEDFQINEIPNSTHFNIDYKYNFVLVEN 1102

  Fly  1118 IEFTQPIHVSADELS 1132
            .:  :.:||:|..:|
 Frog  1103 NK--RKVHVNATSIS 1115

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	71/218 (33%)
		ADAMTS_CR_2	561..625	CDD:465496	20/65 (31%)
		TSP1	683..741	CDD:214559	16/62 (26%)
adamts12	XP_017946319.2	Pep_M12B_propep	65..200	CDD:460254	36/197 (18%)
		ZnMc_ADAMTS_like	258..465	CDD:239801	72/221 (33%)
		ADAMTS_CR_2	480..544	CDD:465496	21/86 (24%)
		TSP1	557..609	CDD:214559	16/62 (26%)
		ADAMTS_CR_3	615..713	CDD:437068	24/101 (24%)
		ADAMTS_spacer1	715..824	CDD:461796	16/126 (13%)
		TSP1_ADAMTS	840..894	CDD:465950	15/59 (25%)
		TSP1_ADAMTS	898..952	CDD:465950	9/53 (17%)
		TSP1_ADAMTS	960..1008	CDD:465950	9/49 (18%)
		TSP1_ADAMTS	1312..1360	CDD:465950
		TSP1_ADAMTS	1363..1418	CDD:465950
		TSP1_ADAMTS	1421..1467	CDD:465950
		TSP1_ADAMTS	1470..1525	CDD:465950