Protein Alignment stl and adamts12

DIOPT Version :10

• Sequence 1: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: XP_068077434.2
• Gene: adamts12 / 100003937
• ZFINID: ZDB-GENE-070705-471
• Length: 1134
• Species: Danio rerio
• Alignment Length: 888
• Identity: 195/888 - (21%)
• Similarity: 282/888 - (31%)
• Gaps: 321/888 - (36%)

  Fly   454 QVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCD---PTMHIMSPKL 515
            :.:|::.:.|||....||.|||.......|.:|||:||:.|::||.:...|:   ....|||.:|
Zfish     6 ETLGLSHLSGMCQPHRSCNINEDSGLPVAFTIAHELGHSFGIQHDGQGNDCEFVGKQPFIMSRQL 70

  Fly   516 --GSGKVTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKN 578
              .|..:|||.||:.|:..||......||.||.|   ..|.:..|..||.|:....||.|::|.|
Zfish    71 QYDSSPLTWSSCSKEYITRFLDRGWGFCLDDRPS---KRDLSTPGAAPGVRYTPQHQCQLQYGPN 132

  Fly   579 FMQASTQSKME-ICRDLHCRQDGLPWTS-HPALEGTECGPNMWCRGGTCEARSSKQGSYSALKSW 641
               |:..|::| :|:.|.|..:|...:. ...::||.|||..||..|.|.....
Zfish   133 ---ATFCSEVENVCQILWCSVNGSCRSKLDSPIDGTRCGPEKWCISGECVIVGK----------- 183

  Fly   642 PPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLE 706
                :||..|                             ..||.||..|.|...|
Zfish   184 ----LPETVH-----------------------------GGWGPWSSWSHCSRTC---------- 205

  Fly   707 GSTGLRTLNRSCLNFP------SRCIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSDPE 765
             ..|::|.:|.| |.|      ..|.|..:|:..|||..|    |:....|....|.:. .:.|.
Zfish   206 -GAGVQTADREC-NQPKPEFGGKYCTGERKRYRVCNTKLC----VRKHPSFREMQCSEF-NTVPY 263

  Fly   766 LTGEGQQLP-STLDASCKIFCR-TRTNGTKSRRWTFPDGTTCKAKQHNPEDITYCISGRCERFSC 828
            .....|.:| |:....|::.|: ...|.::.......|||.| ...:|..:|  |::|.|:...|
Zfish   264 HNELYQWIPVSSPSRPCELHCKPVDENFSEKMLDAVTDGTPC-FMNNNSRNI--CVNGVCKEVGC 325

  Fly   829 DNSTSNFFKMDS--------SFCEARSVRP-------------------TRDSSDQESRQQTN-- 864
            |...::..|.||        |.||  :|:.                   .||...||..:..|
Zfish   326 DFGINSNAKEDSCGVCLGDGSTCE--TVKENFVEQDGFGYMDLVLIPAGARDIYIQEVEEAGNFL 388

  Fly   865 -----------------RQRYAERQEGKPQKNH-------------------------------- 880
                             .|...|.:.|..:.|:
Zfish   389 AMRASDSDEYYLNGNYIIQWNGEYEAGGTKFNYERSGNIENLTSAGPTTEPVMIQLLFQELNPGV 453

  Fly   881 -YENEVAKRPSYGQGNHINAPASPYKRRNY------------HKP---YPPEI-----------P 918
             ||..:.:|...  ||.|..|...:|...:            |:|   :.||:           .
Zfish   454 KYEYTIKRRRPL--GNEILEPEYIWKHGAWTDCSTTCGLGEQHQPVRCFEPEVGVVEENLCDPST 516

  Fly   919 RP-------------------------------------------------------------PP 922
            ||                                                             |.
Zfish   517 RPDDKHRKCKSRDCPARWWVGGWQTCSSTCGSTGVKKRTILCVRTVAGEERVLHPGDCKQLLKPK 581

  Fly   923 PASASLIALDRSSSSESEWVAHPGCHSNCMTDSKGVQGVTSRLTGVESIQLCSYRIQPCER---- 983
            ||    :..:|.....|||..  |..|.|.....|  |:.||:  |:.:.....|..|..|
Zfish   582 PA----VPCNRDVPCGSEWTV--GNWSECSQSCDG--GIKSRM--VKCVAKQPSRCNPATRPRST 636

  Fly   984 ----LQTAAEYAEQTCARYRQKVRGLSGHG---AQISASIDEPDRSCRVGCQD------------ 1029
                ||:.:.....|..|:|.:.......|   .|.|.:|..|:.|..:..|.
Zfish   637 ILCNLQSCSSTNRWTGPRFRPRKIPTQPPGTQTTQYSPTITPPNTSTPITTQSNTSPTSDIIHED 701

  Fly  1030 --EFIKYRYYLVNGRNGHFPPGTRCSPVGKRYCVYGRCLEFGDDDL-PLDKTHISLGQLRTRRKR 1091
              :||     ||...|...|..|..              |.|..|| |.||:: :.|........
Zfish   702 DKDFI-----LVKKNNVAVPTITED--------------EEGSTDLQPPDKSY-TPGYDYIEDPE 746

  Fly  1092 SSISNDLFNITEIFIKPSHSDISAENIEFTQPIHVSADELSSK 1134
            ....:|||.     .||....||:     .|||.:||...::|
Zfish   747 RIREDDLFT-----SKPEEVLISS-----VQPITMSAPVSTTK 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	33/93 (35%)
		ADAMTS_CR_2	561..625	CDD:465496	23/65 (35%)
		TSP1	683..741	CDD:214559	19/63 (30%)
adamts12	XP_068077434.2	None