DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stl and LOC100002059

DIOPT Version :9

Sequence 1:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_001341935.2	Gene:	LOC100002059 / 100002059	-ID:	-	Length:	935	Species:	Danio rerio

Alignment Length:	735	Identity:	186/735 - (25%)
Similarity:	271/735 - (36%)	Gaps:	203/735 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 LIDDAFIFIRRTENGTQFVEHSPQLLK--RLERCFY-------RSPAAALDLCEPGNVRGVFQQN 219
            |.|.:|:....|...|.    ||..|.  .|.||||       .:..|||.||  |.|||.|..|
Zfish    66 LPDSSFLAPDDTFQDTS----SPSALSGDELRRCFYSGDINADMNSYAALSLC--GGVRGAFSYN 124

  Fly   220 GSDLVIHPLPARFGTGTHVLYQARVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPRRR-L 283
            |.:.:|                              .||||..|.|.     ||.:.:..||: |
Zfish   125 GMEYII------------------------------ERRTAPELISD-----DAGKTHVIRRKNL 154

  Fly   284 RA-----------QSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRS-RWSDIPEELFIETA 336
            .|           |..::|      ..::.|...|.:......:....|| |::.||.  ::|..
Zfish   155 NAPNLSKCGVTSNQEVVES------LDKYKHLKGHTKNLTETLLRSMSRSKRFASIPR--YVEVL 211

  Fly   337 IFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGL 401
            :..|..    |.|....:.:    .:||.:::....||.||::...|:.|:.:|.:....: .|.
Zfish   212 VVADES----MAKFHGDDLK----HYLLTLLSVTAKLYKHPSILNAISIVVVKLIVINEAE-KGP 267

  Fly   402 VRSRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCT 466
            ..|.:....|.:||.||:|||..:|..|.::|.|::.|..||.    |......:|||.|..||.
Zfish   268 KVSSNAALTLRNFCTWQKKLNKVNDKHPEYWDTAILFTKQDLC----GATTCDTLGMADVGTMCD 328

  Fly   467 SIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPTM------HIMSPKL--GSGKVTWS 523
            ...||::.|.....|.|..|||:||...|.||..: :|:...      |:|||.|  ......||
Zfish   329 PKRSCSVIEDDGLPSAFTTAHELGHVFSMPHDNVK-ACEDVFGKLKDNHMMSPTLIQIDHHTPWS 392

  Fly   524 KCSRTYLEDFLMDPQAECLFDRDS--FAGPWDHTAGGRLPGERFNANQQCMLRFGKN-----FMQ 581
            .||...:.|||.....:||.|:..  .|.|.|.      ||..::..:||.|.||..     :||
Zfish   393 VCSAAIITDFLDSGHGDCLLDQPQKLMALPEDP------PGISYSLGRQCELAFGSGSKPCPYMQ 451

  Fly   582 AST------QSKME-ICRDLHCRQDGLPWTSHPALEGTECGPNMWCRGGTCEARSSKQGSYSALK 639
            |.:      ::|.: :|:..|     .||.     :||.||.|..|..|||   :.||
Zfish   452 ACSKLWCTGKAKGQLVCQTRH-----FPWA-----DGTACGTNKLCYRGTC---TEKQ------- 496

  Fly   640 SWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRL 704
                                          |...|::.|   .||.|.         |||...|.
Zfish   497 ------------------------------NTFKNKVDG---RWGRWG---------LYGPCSRS 519

  Fly   705 LEGSTGLRTLNRSCLN-FPSR----CIGRDRRFVTCNTPQC-------HKVPVQTINDFATQVCM 757
            ..|  |::...|.|.| .|..    |.|...:..:||...|       .:...:..|.|.    :
Zfish   520 CGG--GVQLAKRDCNNPVPENGGKYCQGLRVKHRSCNLEPCKDSGKTFREEQCEMFNGFT----L 578

  Fly   758 QARKSDPELTGEGQQLPSTLDASCKIFCRTRTNGTKSRRWTFP---DGTTCKAKQHNPEDITYCI 819
            ...:..|.:....:....::...||:.|  |.|||.......|   |||.|     :|:....|:
Zfish   579 NTNRLSPSVVWVPKYSGVSVKDRCKLIC--RANGTGYFYVLAPKVVDGTPC-----SPDTSAVCV 636

  Fly   820 SGRCERFSCDNSTSNFFKMD 839
            .|:|.:..||...::..|.|
Zfish   637 QGKCIKAGCDGKLNSNMKFD 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	26/83 (31%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	64/219 (29%)
		Reprolysin	332..545	CDD:279729	65/220 (30%)
		TSP1	683..741	CDD:214559	18/69 (26%)
LOC100002059	XP_001341935.2	Pep_M12B_propep	48..149	CDD:279848	34/123 (28%)
		Reprolysin	206..415	CDD:279729	66/224 (29%)
		ZnMc_ADAMTS_like	206..412	CDD:239801	64/221 (29%)
		ADAM_CR	426..495	CDD:301627	24/81 (30%)
		TSP1	507..558	CDD:214559	17/61 (28%)
		ADAM_spacer1	669..785	CDD:283607
		TSP1	829..880	CDD:214559
		TSP1	882..935	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810