DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycB and CCNB2

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_004692.1	Gene:	CCNB2 / 9133	HGNCID:	1580	Length:	398	Species:	Homo sapiens

Alignment Length:	449	Identity:	157/449 - (34%)
Similarity:	226/449 - (50%)	Gaps:	96/449 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 GVSAFLRSN---------SVRNRVPTKTT-----VEPTKVTVKSSSSENVN---EPTLKREDSNL 153
            ||::.::|:         .:.|||.|:..     .:.|||.|:.:.:.|||   :||
Human    19 GVNSKVKSHVTIRRTVLEEIGNRVTTRAAQVAKKAQNTKVPVQPTKTTNVNKQLKPT-------- 75

  Fly   154 SKKSLTKLRAALAKPV----MGVSGIRREPVAVSRKEAETKKELPETKKDSLEVKKDATRMPLIR 214
                      |..|||    :...|....|..||.||    :.|.:...|:|
Human    76 ----------ASVKPVQMEKLAPKGPSPTPEDVSMKE----ENLCQAFSDAL------------- 113

  Fly   215 GNSAVTTTTSTMPTTMSLSSKRLAGIEDIDANDKENLVLVSEYVNDIYDYLYQVELEQPIHKDHL 279
                                  |..|||||..|.||..|.|:||.|||.||.|:|:.|.|:...|
Human   114 ----------------------LCKIEDIDNEDWENPQLCSDYVKDIYQYLRQLEVLQSINPHFL 156

  Fly   280 AGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRTYLQLVGVTALFIA 344
            .| ::::.:|||:|:||:.:||.:|.|..||..:.|.|:||:|| |:...|..|||||:|||.:|
Human   157 DG-RDINGRMRAILVDWLVQVHSKFRLLQETLYMCVGIMDRFLQ-VQPVSRKKLQLVGITALLLA 219

  Fly   345 TKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDCNLSRPLPIHFLRRYSKAAGAEDEHH 409
            :||||:|.|.|.|||:|||:.||:.|||:||..|.|.:...|.||||:|||||.|||...:.|.|
Human   220 SKYEEMFSPNIEDFVYITDNAYTSSQIREMETLILKELKFELGRPLPLHFLRRASKAGEVDVEQH 284

  Fly   410 TMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNHRAGTGFNDRHWTPTLTFYSRYSAAH 474
            |::||.:||..:||:|..|.||::|||:..||..:|      |.|    .|.....:|:.|:...
Human   285 TLAKYLMELTLIDYDMVHYHPSKVAAAASCLSQKVL------GQG----KWNLKQQYYTGYTENE 339

  Fly   475 LRPITRLIAK--LARDAPQAKLKAIYNKYQGSKFQKIALRTELTGA----LMDSIVGQS 527
            :..:.:.:||  :..:....|..||.|||..||..||::..:|...    |...::|:|
Human   340 VLEVMQHMAKNVVKVNENLTKFIAIKNKYASSKLLKISMIPQLNSKAVKDLASPLIGRS 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	62/126 (49%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	47/127 (37%)
CCNB2	NP_004692.1	Cyclin_N	137..262	CDD:278560	62/126 (49%)
CCNB2	NP_004692.1	Cyclin_C	264..382	CDD:281044	47/127 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146256
Domainoid	1	1.000	133	1.000	Domainoid score	I5076
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3349
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D475911at33208
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	1	1.000	-	-		otm41118
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	1	1.100	-	-	LDO	PTHR10177
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R194
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790