DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycB and CCND3

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001751.1	Gene:	CCND3 / 896	HGNCID:	1585	Length:	292	Species:	Homo sapiens

Alignment Length:	164	Identity:	51/164 - (31%)
Similarity:	77/164 - (46%)	Gaps:	11/164 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 QKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRTYLQLVGVTALFIATK 346
            |:|:...||.:|..|:.||..:.....|.|.||:..:||||..| .|::..|||:|...:.:|:|
Human    49 QREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCV-PTRKAQLQLLGAVCMLLASK 112

  Fly   347 YEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDCNLSRPLPIHF----LRRYSKAAGAEDE 407
            ..|..|..|......||...:.||:|..|:.:...:..:|:..:...|    |.|.|.   ..|.
Human   113 LRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSL---PRDR 174

  Fly   408 HHTMSKY---FIELASVDYEMATYRPSEIAAASL 438
            ...:.|:   |:.|.:.||..|.|.||.||..|:
Human   175 QALVKKHAQTFLALCATDYTFAMYPPSMIATGSI 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	33/104 (32%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	17/57 (30%)
CCND3	NP_001751.1	Cyclin_N	27..153	CDD:306612	33/104 (32%)
		Cyclin_C	155..>251	CDD:308564	17/57 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	254..292
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146271
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840