Protein Alignment CycB and CCND2

DIOPT Version :10

• Sequence 1: NP_726244.1
• Gene: CycB / 37618
• FlyBaseID: FBgn0000405
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001750.1
• Gene: CCND2 / 894
• HGNCID: 1583
• Length: 289
• Species: Homo sapiens
• Alignment Length: 276
• Identity: 66/276 - (23%)
• Similarity: 119/276 - (43%)
• Gaps: 52/276 - (18%)

  Fly   249 ENLVLVSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQL 313
            :||:.:.|      .||.|....:.:       ||::...||.::..|:.||..:.....|.|.|
Human    28 QNLLTIEE------RYLPQCSYFKCV-------QKDIQPYMRRMVATWMLEVCEEQKCEEEVFPL 79

  Fly   314 AVAIIDRYLQVVKDTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQI 378
            |:..:||:|..| .|.:::|||:|...:|:|:|.:|..|.........||::...:::.:.||.:
Human    80 AMNYLDRFLAGV-PTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVV 143

  Fly   379 FKAIDCNLSRPLPIHFLRRYSKAAGAEDEHHTM----SKYFIELASVDYEMATYRPSEIAAASLF 439
            ...:..||:...|..|:....:....:.|..::    ::.||.|.:.|::.|.|.||.||..|:.
Human   144 LGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSVG 208

  Fly   440 LSLHLLNGNHRAGTGFNDRHWTPTLTFYSRYSAAHLRPITRLIAKLAR------DAPQAKLKAI- 497
            .::          .|........:||         ...:|.|:||:..      .|.|.:::|:
Human   209 AAI----------CGLQQDEEVSSLT---------CDALTELLAKITNTDVDCLKACQEQIEAVL 254

  Fly   498 ------YNKYQ--GSK 505
                  |.:.|  |||
Human   255 LNSLQQYRQDQRDGSK 270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	CYCLIN_CCNB1-like_rpt1	254..384	CDD:410211	33/129 (26%)
		CYCLIN_CCNB1-like_rpt2	389..509	CDD:410213	29/136 (21%)
CCND2	NP_001750.1	CYCLIN_SF	1..150	CDD:477360	35/135 (26%)
		CYCLIN_CCND2_rpt2	155..259	CDD:410280	24/122 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..289		4/7 (57%)