DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycB and CCNB1

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_114172.1	Gene:	CCNB1 / 891	HGNCID:	1579	Length:	433	Species:	Homo sapiens

Alignment Length:	473	Identity:	166/473 - (35%)
Similarity:	244/473 - (51%)	Gaps:	63/473 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LKLTDALRNAKARVDSHWKKQPLGSTNGNGNGAVPPKVNEGGVSAFLRSNSVRNRVPTKTTVE-P 128
            |::|   ||:|...::   |..:...........|...::.|:........:.|:|..:...: |
Human     3 LRVT---RNSKINAEN---KAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKMP 61

  Fly   129 TKVTVKSSSSENVNEPTLKREDSNLSKKSLTKLRAALAKPVMGVSGIRREPVAVSRKEAETKKEL 193
            .|...|.|::..|           :.||        |.||:..|..:...||:....|.|.:.|.
Human    62 MKKEAKPSATGKV-----------IDKK--------LPKPLEKVPMLVPVPVSEPVPEPEPEPEP 107

  Fly   194 PETKKDSLEVKKDATRMPLIRGNSAVTTTTSTMPTT----------MSLSSKRLAGIEDIDANDK 248
            ...|::.|..:      |::    ..|.:.|.|.|:          .:.|...|| :.|:||.|.
Human   108 EPVKEEKLSPE------PIL----VDTASPSPMETSGCAPAEEDLCQAFSDVILA-VNDVDAEDG 161

  Fly   249 ENLVLVSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQL 313
            .:..|.||||.|||.||.|:|.||.:...:|.| :||:..|||:||||:.:|.::|.|..||..:
Human   162 ADPNLCSEYVKDIYAYLRQLEEEQAVRPKYLLG-REVTGNMRAILIDWLVQVQMKFRLLQETMYM 225

  Fly   314 AVAIIDRYLQVVKDTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQI 378
            .|:||||::| .....:..||||||||:|||:||||::||.||||.|:||:|||..||||||::|
Human   226 TVSIIDRFMQ-NNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKI 289

  Fly   379 FKAIDCNLSRPLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLH 443
            .:|::..|.||||:|||||.||....:.|.||::||.:||..:||:|..:.||:|||.:..|:|.
Human   290 LRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALK 354

  Fly   444 LL-NGNHRAGTGFNDRHWTPTLTFYSRYSAAHLRPITRLIAKLARDAPQAKLK--AIYNKYQGSK 505
            :| ||           .|||||..|..|:...|.|:.:.:||......|...|  .:.|||..||
Human   355 ILDNG-----------EWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSK 408

  Fly   506 FQKIALRTELTGALMDSI 523
            ..||:...:|..||:..:
Human   409 HAKISTLPQLNSALVQDL 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	66/126 (52%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	50/128 (39%)
CCNB1	NP_114172.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..47		2/27 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..116		6/22 (27%)
		Interaction with CDK2	169..177		6/7 (86%)
		Cyclin_N	173..298	CDD:278560	66/126 (52%)
		Interaction with CDK2	258..261		2/2 (100%)
		Cyclin_C	300..418	CDD:281044	50/128 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146255
Domainoid	1	1.000	133	1.000	Domainoid score	I5076
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68982
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3349
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D475911at33208
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	1	1.000	-	-		otm41118
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R194
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790