DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycB and CCNA2

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001228.2	Gene:	CCNA2 / 890	HGNCID:	1578	Length:	432	Species:	Homo sapiens

Alignment Length:	468	Identity:	124/468 - (26%)
Similarity:	212/468 - (45%)	Gaps:	97/468 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 GNGAVPPKVNEGGVSAFLRSNSVRNRVPTKTTVEPTKVTVKSSSSENVNEPTLKREDSNLSKKSL 158
            ||.|..|...|.| ||.|...        :|.::..:..:....:..|.:|
Human     3 GNSAPGPATREAG-SALLALQ--------QTALQEDQENINPEKAAPVQQP-------------- 44

  Fly   159 TKLRAALAKPVMG-VSGIRREPVAVSRKEAETKK--------ELPETKKDSL---------EVKK 205
             :.|||||....| ..|:.::....:|:.|..|.        .:|..|.:|.         |.:|
Human    45 -RTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEK 108

  Fly   206 DATRMP----------LIRGNSAVTTT---------------TSTMPTTMSLSSKRLAGIED--- 242
            :|.:.|          .:..|||::..               :...|.||.:|    ..:||
Human   109 EAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMS----IILEDEKP 169

  Fly   243 IDANDKENLVLVSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLA 307
            :..|:      |.:|..||:.||.::|::......::..|.::::.|||:|:||:.||..::.|.
Human   170 VSVNE------VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQ 228

  Fly   308 AETFQLAVAIIDRYLQVVKDTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIR 372
            .||..|||..|||:|..: ...|..|||||..|:.:|:|:||::||.:.:||:|||||||.:|:.
Human   229 NETLHLAVNYIDRFLSSM-SVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVL 292

  Fly   373 QMELQIFKAIDCNLSRPLPIHFLRRY---SKAAGAEDEHHTMSKYFIELASVDYE-MATYRPSEI 433
            :||..:.|.:..:|:.|....||.:|   .:.|..:.|  :::.:..||:.:|.: ...|.||.|
Human   293 RMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVE--SLAMFLGELSLIDADPYLKYLPSVI 355

  Fly   434 AAASLFLSLHLLNGNHRAGTGFNDRHWTPTLTFYSRYSAAHLRPITRLIAKLARDAPQAKLKAIY 498
            |.|:..|:|:.:.|          :.|..:|...:.|:...|:|....:.:....|||...::|.
Human   356 AGAAFHLALYTVTG----------QSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIR 410

  Fly   499 NKYQGSKFQKIAL 511
            .||:.||:..::|
Human   411 EKYKNSKYHGVSL 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	50/126 (40%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	32/127 (25%)
CCNA2	NP_001228.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..45		2/33 (6%)
		Cyclin_N2	28..166	CDD:406812	26/156 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..75		4/19 (21%)
		CYCLIN_CCNA2_rpt1	175..305	CDD:410264	52/130 (40%)
		CYCLIN_CCNA2_rpt2	309..419	CDD:410267	31/121 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146276
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650