DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycB and CLB2

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_015444.1	Gene:	CLB2 / 856236	SGDID:	S000006323	Length:	491	Species:	Saccharomyces cerevisiae

Alignment Length:	514	Identity:	145/514 - (28%)
Similarity:	237/514 - (46%)	Gaps:	94/514 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 ISRPIAAKDAAQKDSKDLKLTDALRNAKARVDSHWKKQPLGSTNGNGNGAVPPKVNEGGVSAFLR 112
            :|.||...:.:|..|.    :..|||.          |.|...|...........|...::.|..
Yeast     1 MSNPIENTENSQNTSS----SRFLRNV----------QRLALNNVTNTTFQKSNANNPALTNFKS 51

  Fly   113 S-NSVR---NRVPTKTTVEPTKVTVKSSSSENVNEPTLKREDSNLSKKSL----------TKLRA 163
            : |||:   :|:|     :.|:.:|..|::....:.|||.....|.|.:|          ::...
Yeast    52 TLNSVKKEGSRIP-----QFTRESVSRSTAAQEEKRTLKENGIQLPKNNLLDDKENQDPSSQQFG 111

  Fly   164 ALAKPVMGVSGIRRE-PVAVSRKEAETKKEL------------PETKKDSLEVKK--DATRMPLI 213
            ||.....|    |.| |..:|.:|:.:.||:            .|...:|:|.:|  .|.....:
Yeast   112 ALTSIKEG----RAELPANISLQESSSAKEIIQHDPLKGVGSSTEVVHNSVENEKLHPARSQLQV 172

  Fly   214 RGNSAVTTTTSTMPTTMSL-------------SSKRLAGIEDIDANDKENLVLVSEYVNDIYDYL 265
            |...:.|.:....|.:..:             :.|.....||:||.|..:..:||||||||::||
Yeast   173 RNTESETDSGKKRPISTIVEQELPKKFKVCDENGKEEYEWEDLDAEDVNDPFMVSEYVNDIFEYL 237

  Fly   266 YQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYL--QVVKDT 328
            :|:|:.....|:.|...:.: |:.|.:|::|:.::|.:|.|..||..||:.|:||:|  ::|:..
Yeast   238 HQLEVITLPKKEDLYQHRNI-HQNRDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLD 301

  Fly   329 KRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDCNLSRPLPIH 393
            |   |||||.:.||||:||||::.|:|..|...||...|..:|::.|..|.|.:..||:.|.|::
Yeast   302 K---LQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKFNLNYPNPMN 363

  Fly   394 FLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNHRAGTGFNDR 458
            ||||.|||...:.:..|::|:.:|::.||:......||..|||::|:|..:|      |.|
Yeast   364 FLRRISKADDYDIQSRTLAKFLLEISLVDFRFIGILPSLCAAAAMFMSRKML------GKG---- 418

  Fly   459 HWTPTLTFYS-RYSAAHLRPITR-----LIAKLARDAPQAKLKAIYNKYQGSKFQKIAL 511
            .|...|..|| .|:...|.|:..     |::.:..|       ..:.|||..:|.|.::
Yeast   419 KWDGNLIHYSGGYTKEELAPVCHMIMDYLVSPIVHD-------EFHRKYQSRRFMKASI 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	49/128 (38%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	38/129 (29%)
CLB2	NP_015444.1	COG5024	8..487	CDD:227357	142/507 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	155	1.000	Inparanoid score	I1086
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	1	1.000	-	-		mtm9224
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R194
SonicParanoid	1	1.000	-	-		X94
TreeFam	0	0.000	Not matched by this tool.
	9	8.790