DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycB and CLB3

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_010126.1	Gene:	CLB3 / 851400	SGDID:	S000002314	Length:	427	Species:	Saccharomyces cerevisiae

Alignment Length:	431	Identity:	129/431 - (29%)
Similarity:	206/431 - (47%)	Gaps:	62/431 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 SAFLRSNSVRNRVPTKTTVEP---TKVTVKSSSSENVNEPTLKRED------SNLSKKSLTKLRA 163
            |..|.|..:|:  |....|.|   .|....|.|..:...|.:...|      :|.|..|::|.:.
Yeast     5 SQSLSSGHIRS--PEDENVAPIGNLKHRTGSLSHISSAHPRVALSDVTNIVATNSSNNSISKPKV 67

  Fly   164 ALAKPVMGVSGIRREP-----VAVSRKEAE-----TKKELPETKKDSLEVKKD--ATRMPLIRGN 216
            |..|..:..:.|..|.     ....||||:     |.:|..|..:|..|.::|  ..:.||:..:
Yeast    68 APIKERLDSAAIIEEERLDANSVAQRKEADHNDLLTDREQEEPVEDDGESEEDEEEDQEPLLLQH 132

  Fly   217 SAVTTTT------STMPTTMSLSSKRLAGIEDIDANDKE--NLVLVSEYVNDIYDYLYQVE-LEQ 272
            .|..|..      :...||             :|.||.:  ::|:|:|..|:|::|:.::| |.:
Yeast   133 YASDTLVWEHAFRTYYRTT-------------LDPNDDDVYDVVMVAELSNEIFEYMRKLEDLYK 184

  Fly   273 PIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYL--QVVKDTKRTYLQL 335
            | :..::..|.|:....|:.|||||.:||.:|.|..||..|.:.||||||  :||...|   .||
Yeast   185 P-NPYYMDKQPELRWSFRSTLIDWIVQVHEKFQLLPETLYLCINIIDRYLCKEVVPVNK---FQL 245

  Fly   336 VGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDCNLSRPLPIHFLRRYSK 400
            ||..:||||.||||:..|.|.|||:::::.|:...:...|..|...::..|..|.|:.||||.||
Yeast   246 VGAASLFIAAKYEEINCPTIKDFVYMSENCYSRNDLLDAERTILNGLEFELGWPGPMSFLRRISK 310

  Fly   401 AAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNHRAGTGFNDRHWTPTLT 465
            |...|.:..|::||.:|...:|:.:.:.:||.:||.:.|||..:|..|          .|:....
Yeast   311 ADDYEHDTRTLAKYLLESTIMDHRLVSAQPSWLAAGAYFLSKIILGQN----------QWSLAHV 365

  Fly   466 FYSRYSAAHLRPITRLIAKLARDAPQAKLKAIYNKYQGSKF 506
            :||.|:...:.|:..:|.:..|.|.: :..||:.||...::
Yeast   366 YYSNYTQEQILPLATIILENCRYASK-RHNAIWRKYSSRRY 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	49/129 (38%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	36/118 (31%)
CLB3	NP_010126.1	COG5024	4..421	CDD:227357	129/431 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344756
Domainoid	1	1.000	61	1.000	Domainoid score	I2525
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68982
Inparanoid	1	1.050	155	1.000	Inparanoid score	I1086
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	1	1.000	-	-		mtm9224
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R194
SonicParanoid	1	1.000	-	-		X94
TreeFam	0	0.000	Not matched by this tool.
	12	11.720