DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycB and CLB4

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_013311.1	Gene:	CLB4 / 850907	SGDID:	S000004200	Length:	460	Species:	Saccharomyces cerevisiae

Alignment Length:	504	Identity:	127/504 - (25%)
Similarity:	234/504 - (46%)	Gaps:	92/504 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DENASENFKQV--QLKKLTVPSMEATTKRAALGDLQNRGISRPIAAKDAAQKDSKDLKLTDALRN 73
            ||||::..|.|  |..:..:..:|...:|.||||:.::                |..|:.:|:.|
Yeast    23 DENANQEVKNVLYQGVQKGIKRLEKRQRRVALGDVTSQ----------------KANKIHNAIHN 71

  Fly    74 AKARVDSHWKKQPLGSTNGNGNGAVPPKVNEGGVSAFLR--SNSVRNRVPTKTTVEPTKVTVKSS 136
            ...:..::::.:.:.|                  ||.::  ...||:.......::.::.:  |:
Yeast    72 KFHQTKNNFEIENIRS------------------SALVKEQQRDVRHEDSDYFLIDSSEGS--ST 116

  Fly   137 SSENVNEPTLKREDSNLSKKSLTKLRAALAKPVMGVSGIRREPVAVSRKEAETKKELPETKKDSL 201
            ..|.|||..:   |..||::                  :..:.:...    |..::.....:|.:
Yeast   117 DDEQVNEDAI---DDLLSRR------------------VNDQQIQAD----EVYEDFDGEMQDVI 156

  Fly   202 EVKKDATRMPLIRGNSAVTTTTSTMPTTMSLS-SKRLAGIEDIDANDKENLVLVSEYVNDIYDYL 265
            |...|:...||...|:      ..:.|.:..: .|....:.:...:|..::|:|.||.:||:.||
Yeast   157 EEDVDSQIEPLSPINN------DEIQTELDRAFEKYFRSVPNPLDDDTHDVVMVVEYASDIFYYL 215

  Fly   266 YQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKR 330
            .::|::...:..::..|.|::...|..:|||:.::|.:|.|..||..|.:.|:||:|     :|:
Yeast   216 RELEVKYRPNPYYMQNQVELTWPFRRTMIDWLVQLHFRFQLLPETLYLTINIVDRFL-----SKK 275

  Fly   331 TY----LQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDCNLSRPLP 391
            |.    .|||||:|||||.|:||:..|.:.|.|::.::|||...|.:.|..:...::..:..|.|
Yeast   276 TVTLNRFQLVGVSALFIAAKFEEINCPTLDDLVYMLENTYTRDDIIRAEQYMIDTLEFEIGWPGP 340

  Fly   392 IHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNHRAGTGFN 456
            :.||||.|||...:.|..|::||.:|...|:.::....||.:||.:.|||..:|        |.|
Yeast   341 MPFLRRISKADDYDFEPRTLAKYLLETTIVEPKLVAAAPSWLAAGAYFLSRTIL--------GSN 397

  Fly   457 DRHWTPTLTFYSRYSAAHLRPITRLIAKLARDAPQAKLKAIYNKYQGSK 505
            |  |:....|||.|:::.:.|:..||.:..::|.: :..:|:.||...|
Yeast   398 D--WSLKHVFYSGYTSSQIIPLASLILENCKNASR-RHHSIWKKYFDQK 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	44/130 (34%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	39/117 (33%)
CLB4	NP_013311.1	COG5024	10..459	CDD:227357	127/504 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344755
Domainoid	1	1.000	61	1.000	Domainoid score	I2525
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	155	1.000	Inparanoid score	I1086
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	1	1.000	-	-		mtm9224
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R194
SonicParanoid	1	1.000	-	-		X94
TreeFam	0	0.000	Not matched by this tool.
	11	10.720