DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycB and CYCB2;2

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_195287.1	Gene:	CYCB2;2 / 829714	AraportID:	AT4G35620	Length:	429	Species:	Arabidopsis thaliana

Alignment Length:	501	Identity:	147/501 - (29%)
Similarity:	218/501 - (43%)	Gaps:	120/501 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 NRG-ISRPIAAKDAAQKDSKDLKLTDALRNAKARVD-SHWKKQPLGSTNGN--GNGAVPPKVNE- 104
            ||. :.:||.  :..|.|.|        |:.|..|: ....::.||..|.|  |..|.|..||:
plant     8 NRNLVVKPIT--EILQDDDK--------RSRKFGVEMKRQNRRALGVINHNLVGAKAYPCVVNKR 62

  Fly   105 GGVSAFLRSNSVRNRVPTKTTVEPTKVTVKSSSSENVNEPTLKREDSNLSKKSLTKLRAALAKPV 169
            .|:|                                      :|:..:..||.|..|..
plant    63 RGLS--------------------------------------QRKQESCDKKKLDSLHP------ 83

  Fly   170 MGVSGIRREPVAVSRKEAETKKELPETKK--DSLEVKKDATRMPLIRGNSAVTTTTSTMPTTMSL 232
                       ::||.:.||||..|...:  |.:.:.::..:      |..||.   ..|..|||
plant    84 -----------SISRSQEETKKLKPSGNEFGDCIFIDEEEEK------NEEVTL---DQPMPMSL 128

  Fly   233 -------------------SSKRLAGIEDIDANDKENLVLVSEYVNDIYDYLYQVELEQPIHKDH 278
                               ..::...:.|||..|..|.:...|||.|:||:..:.|....:..|:
plant   129 EEPYIEFDPMEEEVEMEDMEEEQEEPVLDIDEYDANNSLAAVEYVQDLYDFYRKTERFSCVPLDY 193

  Fly   279 LAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYL--QVVKDTKRTYLQLVGVTAL 341
            :|.|.::|.||||:||||:.|||.:|.|..||..|.|.:|||:|  |.|   .|..|||||:.||
plant   194 MAQQFDISDKMRAILIDWLIEVHDKFELMNETLFLTVNLIDRFLSKQAV---ARKKLQLVGLVAL 255

  Fly   342 FIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDCNLSRPLPIHFLRRYSKAAGAED 406
            .:|.||||:..|.:.|.|.|:|..||...:.:||..:...:..|:|.|....||:|:.|||.::.
plant   256 LLACKYEEVSVPIVEDLVVISDKAYTRTDVLEMEKIMLSTLQFNMSLPTQYPFLKRFLKAAQSDK 320

  Fly   407 EHHTMSKYFIELASVDYEMATYRPSEIAAASLF---LSLHLLNGNHRAGTGFNDRHWTPTLTFYS 468
            :...::.:.||||.|||||..|.||.:||.:::   .::|          ||::  |..|..|:.
plant   321 KLEILASFLIELALVDYEMVRYPPSLLAATAVYTAQCTIH----------GFSE--WNSTCEFHC 373

  Fly   469 RYSAAHLRPITRLIAKLARDAPQAKLKAIYNKYQGSKFQKIALRTE 514
            .||...|....|.:.:|.:.|...||..::.||..|||..||.:.|
plant   374 HYSENQLLECCRRMVRLHQKAGTDKLTGVHRKYSSSKFGYIATKYE 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	54/128 (42%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	43/129 (33%)
CYCB2;2	NP_195287.1	COG5024	<157..412	CDD:227357	102/269 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	71	1.000	Domainoid score	I3347
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I1359
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	1	1.000	-	-		otm3050
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.830