DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycB and ccnb1

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_571588.1	Gene:	ccnb1 / 58025	ZFINID:	ZDB-GENE-000406-10	Length:	398	Species:	Danio rerio

Alignment Length:	428	Identity:	161/428 - (37%)
Similarity:	236/428 - (55%)	Gaps:	55/428 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 LRSNSVRNRVPTKTTV-EPTKVTVKSSSSENVNEPTLKREDSNLSKKSLTKLRAALAKPVMGVSG 174
            |.|:..:|.:|.|..| ....:..:::..|..|.|..::.   |.||   :::.|.|..|:
Zfish    12 LASSENQNALPGKAVVANKPGLRPRAALGEIGNNPQTRQA---LKKK---EVKVAPAAEVV---- 66

  Fly   175 IRREPVAVSRKEAETKKELPETKKDSLEVKKDATRMPLIRGNSAVTTTTSTMPTTMS-------- 231
            :.:.||            :.:.||||.:|:         .|...|:..:|.:|...|
Zfish    67 VEKAPV------------VQQPKKDSPKVQ---------HGVKVVSEPSSPVPMETSGCASDDLC 110

  Fly   232 -LSSKRLAGIEDIDANDKENLVLVSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLID 295
             ..|..|..|:|:||:|.:|.:|.||||.|||.||.|:|.||.:...:||| |||:..|||:|||
Zfish   111 QAFSDVLLNIKDVDADDYDNPMLCSEYVKDIYLYLRQLETEQAVRPKYLAG-KEVTGNMRAILID 174

  Fly   296 WINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRTYLQLVGVTALFIATKYEELFPPAIGDFVF 360
            |:.:|.::|.|..||..:.||||||:||.....|: .||||||||:|||:||||::||.|.||.|
Zfish   175 WLVQVQIKFRLLQETMYMTVAIIDRFLQDHPVPKK-QLQLVGVTAMFIASKYEEMYPPEIADFAF 238

  Fly   361 ITDDTYTARQIRQMELQIFKAIDCNLSRPLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEM 425
            :||..||..|||:||:::.:.::....||||:.||||.||......||||::|||:||..|||:|
Zfish   239 VTDRAYTTSQIREMEMKVLRVLNFGFGRPLPLQFLRRASKIGDVTAEHHTLAKYFLELTMVDYDM 303

  Fly   426 ATYRPSEIAAASLFLSLHLLNGNHRAGTGFNDRHWTPTLTFYSRYSAAHLRPITRLIAK--LARD 488
            ..|.||::|:|:..|:|.:          ||...|||||..|..|:...|.|:.:.|||  :..:
Zfish   304 VHYPPSQMASAAYALTLKV----------FNCGDWTPTLQHYMGYTEDELVPVMQHIAKNVVRVN 358

  Fly   489 APQAKLKAIYNKYQGSKFQKIALRTELTGALMDSIVGQ 526
            ...:|..|:.|||...|..:||..::|..:|:..:..|
Zfish   359 EGLSKHLAVKNKYSSQKQMRIATISQLKSSLIKDLAKQ 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	66/126 (52%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	51/127 (40%)
ccnb1	NP_571588.1	Cyclin_N	140..262	CDD:278560	66/123 (54%)
ccnb1	NP_571588.1	Cyclin_C	267..385	CDD:281044	51/127 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579830
Domainoid	1	1.000	130	1.000	Domainoid score	I5173
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68982
Inparanoid	1	1.050	245	1.000	Inparanoid score	I3267
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D475911at33208
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	1	1.000	-	-		otm25239
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R194
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790