DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycB and CycB3

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001262934.1	Gene:	CycB3 / 42971	FlyBaseID:	FBgn0015625	Length:	575	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	157/574 - (27%)
Similarity:	240/574 - (41%)	Gaps:	121/574 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 EATTKRA-----------------ALGDLQNRGISRPIAA-------------KDAAQKDSKDLK 66
            :|||:.|                 |||....:|::|..||             :...:.|...:|
  Fly     5 KATTRAAITSGHHQLQQAVNPILGALGAATRKGLTRRAAATGNIDPNVENMQTRAKRKADHSPIK 69

  Fly    67 LTDALRNAKARVDSHWKKQPLGSTNGNGNGAVPPKVNEGGVSAFLRSNSVRNRVPTKTTVEPTKV 131
            .....|:|...:.::.|...|..........|..|.....:.|.:.:....|.  :......:|:
  Fly    70 NDKIKRSALGNLTNNVKIMTLHPAQDEEQSGVGKKPTAQQLQALMDAKKQENL--SVNVFGASKM 132

  Fly   132 TVKSSSSENVNEPTLKREDS-NLSKKSLTKLRAALAKPVMGVSGIRREPVAVSRKEAETKKELPE 195
            |.::||         |.||| ....|.|.||..|||:|..     |.:.|..::|....:.:||.
  Fly   133 TTRASS---------KVEDSVENCHKVLDKLEEALARPKP-----RPKAVPAAKKTVLGEVQLPA 183

  Fly   196 TKK-----------DSLEVKKDATRMPLIRGNSAVTTT-----TSTMPTTMSLSSKRLAG----- 239
            ...           .:|...:.|...|:.|.::....|     .|.:....|..|.||:|
  Fly   184 MPNPMQIPVLLPPTHNLAAPQVAAVKPVRRISNDFNKTEDSLYMSALEDVSSCDSMRLSGNFEAA 248

  Fly   240 ---------------------------------------IEDIDANDKENLVLVSEYVNDIYDYL 265
                                                   :||.|..:.::...||.|..||::||
  Fly   249 RRRSAKLQQKTEQQPQPLLLTLPETAPSQVVPIPPVPEEVEDFDRKNWDDPFQVSHYAMDIFNYL 313

  Fly   266 YQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYL--QVVKDT 328
            ...|.|.|| .|::..|..::..||.:|:||:.||...|.|..||..|||.|:|.||  :|:...
  Fly   314 KVREAEFPI-ADYMPRQIHLTTWMRTLLVDWMVEVQETFELNHETLYLAVKIVDLYLCREVINKE 377

  Fly   329 KRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDCNLSRPLPIH 393
            |   |||:|..|.|||.||:|..||.|.||::|.|..|...::.:||.:..:.|..:|..||...
  Fly   378 K---LQLLGAAAFFIACKYDERQPPLIEDFLYICDGAYNHDELVRMERETLRVIKYDLGIPLSYR 439

  Fly   394 FLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNHRAGTGFNDR 458
            |||||::.|.......|:::|.:||:.:||...::..|::|:|:||::|.:     ..|.|..|:
  Fly   440 FLRRYARCAKVPMPTLTLARYILELSLMDYANISFSDSQMASAALFMALRM-----HGGPGQLDK 499

  Fly   459 H-WTPTLTFYSRYSAAHLRPI-TRLIAKLARDAPQAKLKAIYNKYQGSKFQKIA 510
            . ||.||.:|:.|..|....| |.|.|.|.| .|:|.:|.|.|||....|.::|
  Fly   500 QTWTSTLIYYTGYQLADFAEIVTALNAGLHR-KPRATIKTIRNKYSHKIFHEVA 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	52/128 (41%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	45/124 (36%)
CycB3	NP_001262934.1	Cyclin_N	308..433	CDD:278560	52/128 (41%)
CycB3	NP_001262934.1	Cyclin_C	435..555	CDD:281044	45/124 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447489
Domainoid	1	1.000	59	1.000	Domainoid score	I3040
eggNOG	1	0.900	-	-		E1_COG5024
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D34088at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9224
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10177
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R194
SonicParanoid	1	1.000	-	-		X94
	9	8.880