DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycB and Ccna1

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001011949.1	Gene:	Ccna1 / 295052	RGDID:	1310639	Length:	421	Species:	Rattus norvegicus

Alignment Length:	264	Identity:	88/264 - (33%)
Similarity:	146/264 - (55%)	Gaps:	14/264 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 NLVLVSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLA 314
            :::.|:||..:|:.||.:.|:.......::..|.:::..|||:|:||:.||..::.|..||..||
  Rat   160 DVINVTEYAEEIHRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVGEEYKLRTETLYLA 224

  Fly   315 VAIIDRYLQVVKDTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIF 379
            |..:||:|..: ...|..|||||..|:.:|:||||::||.:.:||:|||||||.||:.:||..:.
  Rat   225 VNFLDRFLSCM-SVLRGKLQLVGTAAILLASKYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLL 288

  Fly   380 KAIDCNLSRPLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYE-MATYRPSEIAAASLFLSLH 443
            |.:..:|:.|....||.:|.:..|.......::||..||:.::.: ...|.||.:|||:..|:.:
  Rat   289 KVLAFDLTVPTTNQFLLQYLRRQGVCIRTENLAKYVAELSLLEADPFLKYLPSLVAAAAYCLANY 353

  Fly   444 LLNGNHRAGTGFNDRH-WTPTLTFYSRYSAAHLRPITRLIAKLARDAPQAKLKAIYNKYQGSKFQ 507
            ::|           || |..||..::.||...:.|....:.|.....|....:||..||:.||:.
  Rat   354 IVN-----------RHFWPETLAAFTGYSLNEIVPCLSELHKACLSIPHRPQQAIREKYKASKYL 407

  Fly   508 KIAL 511
            .::|
  Rat   408 HVSL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	50/126 (40%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	34/125 (27%)
Ccna1	NP_001011949.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Cyclin_N2	27..>101	CDD:406812
		CYCLIN_CCNA1_rpt1	132..294	CDD:410263	53/134 (40%)
		CYCLIN_CCNA1_rpt2	298..420	CDD:410266	34/125 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340037
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650