DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycB and ccnf

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_996931.1	Gene:	ccnf / 266981	ZFINID:	ZDB-GENE-021030-2	Length:	764	Species:	Danio rerio

Alignment Length:	488	Identity:	98/488 - (20%)
Similarity:	191/488 - (39%)	Gaps:	109/488 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 SVRNRVPTKTTV---------EPTKVTVKSSSSENVNEPTLKRED------SNLSKKSLT---KL 161
            |.::|.|...||         ...:..||...:...||..|..|:      ..::.:.|:   .|
Zfish    76 SFKDRWPAPDTVWLFERAAEKGNFEAAVKLGIAYLYNEGPLLSEEGRADLCGRMASRYLSLSESL 140

  Fly   162 RAALAKPVM--------GVSGIRREPVAVSRKEAETKKELP-------------------ETKKD 199
            |:..|:|.:        .|||...:.|...|.:||.:.. |                   |.|:|
Zfish   141 RSPQAEPFIWLFIRPPWSVSGSCCKAVVFDRLQAECQTS-PGRKGTLLYCLARVLQLFDDEEKRD 204

  Fly   200 SLEVK-KDATRMPLIRGNS---AVTTTTST---------MPTTMSLSSK-----RLAGIEDI-DA 245
            ..|:. |:::|...::.:.   |::..:||         |.|....:::     :||.::.. .|
Zfish   205 EAELMLKESSRCGSLQSSYLLWAISRASSTADPGRYLQCMRTLRDYAARGCWEAQLAFVKSCGSA 269

  Fly   246 NDKENLVLVSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAET 310
            |.   |.|.....:::....:|.......::.||.|| :::.| |.:|:||:.||......:::.
Zfish   270 NP---LGLEPRACSELVSQFFQTGPSALRYQPHLQGQ-DITTK-RYILVDWLVEVTTTKDFSSQV 329

  Fly   311 FQLAVAIIDRYLQVVKDTKRTYLQLVGVTALFIATKY--EELFPPAIGDFVFITDDTYTARQIRQ 373
            ..:.::.:||||. ::...:..|||:|:..:.|.|::  :|:.  .|.:.|::||:||....:..
Zfish   330 LHVTISCVDRYLH-LRSVPKAQLQLLGIACMVICTRFISKEIL--TIREAVWLTDNTYQYEDLVH 391

  Fly   374 MELQIFKAIDCNLSRPLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASL 438
            |..::...:|..:..|..:.:..........|.....:..|..||:.:........|:.:|:|.|
Zfish   392 MMGEVISVLDGKIRTPTVLDYGEVLLSLLPVERRTAHLFSYICELSLLCSPATVPGPARLASAIL 456

  Fly   439 FLSLHLLN------GNHRAGTGFNDRHWTP-TLTFYSRYSAAHLRPITRLIAKLARDAPQ----A 492
            .|:..|.|      ......|||:.:.... .||.|              |....:|.|:    .
Zfish   457 LLTRALHNYVPVWPVQLEENTGFSKQDLVSCALTLY--------------IKCFGQDVPKDYRHV 507

  Fly   493 KLKAIYNKYQGSKFQKIALRTELTGALMDSIVG 525
            .|..:..:::...:|:|:         .|:::|
Zfish   508 SLTGVKQRFEDDSYQQIS---------KDTVMG 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	31/128 (24%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	24/136 (18%)
ccnf	NP_996931.1	Nuclear localization signal 1. /evidence=ECO:0000250	19..27
		Cyclin_N	299..405	CDD:278560	30/110 (27%)
		Cyclin_C	428..526	CDD:281044	22/120 (18%)
		Nuclear localization signal 2. /evidence=ECO:0000250	570..575
		PEST	583..738
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..754
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579850
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930