DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycB and Ccne1

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001094291.1	Gene:	Ccne1 / 25729	RGDID:	2294	Length:	411	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	100/408 - (24%)
Similarity:	169/408 - (41%)	Gaps:	113/408 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 KDAAQKDSKDLKLTDALRNAKARVDSHWKKQPLGSTNGNGNGAVPPKVNEGGVSAFLRSNSVRNR 119
            ::..::||||              .|:.|::      |..:.:|..:..:..|:.||:.
  Rat     3 RERKERDSKD--------------HSNMKEE------GGSDLSVRSRKRKANVAVFLQD------ 41

  Fly   120 VPTKTTVEPTKVTVKSSSSENVNEPTLKREDSNLSKKSLTKLRAALAKPVMGVSGIRREPVAVSR 184
             |.:...:..| ||||..|   ::|.  .:||            |...|.        ..:....
  Rat    42 -PDEEIAKIDK-TVKSQDS---SQPW--DDDS------------ACVDPC--------SFIPTPN 79

  Fly   185 KEAETKKELPETKKDSLEVKKD-ATRMPLIR-GNSAVTTTTSTMPTTMSLSSKRLAGIEDI--DA 245
            ||.:.:.|.|:|.....:::.. |:.:|::. ||.                       |::  ..
  Rat    80 KEEDNELEYPKTAFQPRKIRPPRASPLPVLNWGNR-----------------------EEVWRIM 121

  Fly   246 NDKENLVLVSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAET 310
            .:||...|..|:      :|.:..|.|.              :|||||:||:.||...:.|..||
  Rat   122 LNKEKTYLRDEH------FLQRHPLLQA--------------RMRAVLLDWLMEVCEVYKLHRET 166

  Fly   311 FQLAVAIIDRYLQVVKDTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQME 375
            |.||....|||:...::..:|.|||:|::|||||:|.||::||.:..|.::||...:..:|..||
  Rat   167 FYLAQDFFDRYMASQQNIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTME 231

  Fly   376 LQIFKAIDCNLSRPLPIHFLRRYSKAAGAEDEHHT-MSKY----FIELAS------VDYEMATYR 429
            |.:.||:...||....:.:|..|.:.|...|.... |.:|    |:::|.      :|.....:.
  Rat   232 LMMMKALKWRLSPLTIVSWLNVYVQVAYVNDTGEVLMPQYPQQVFVQIAELLDLCVLDVGCLEFP 296

  Fly   430 PSEIAAASL--FLSLHLL 445
            ...:||::|  |.||.|:
  Rat   297 YGVLAASALYHFSSLELM 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	45/126 (36%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	16/70 (23%)
Ccne1	NP_001094291.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		12/67 (18%)
		CYCLIN_SF	104..240	CDD:424085	53/178 (30%)
		CYCLIN_CCNE1_rpt2	244..357	CDD:410284	16/71 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..411
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340033
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750