DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycB and cig1

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_588110.2	Gene:	cig1 / 2539433	PomBaseID:	SPCC4E9.02	Length:	415	Species:	Schizosaccharomyces pombe

Alignment Length:	410	Identity:	116/410 - (28%)
Similarity:	194/410 - (47%)	Gaps:	61/410 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 NEPTLKREDSNLSKKSLTKLRAALAKPVMGVSGIRR--EPV--------AVSRKEAET------- 189
            :|..|:::...:.|||..||...:..|...|..|.:  ||.        ::|....:|
pombe    15 DENQLQKDHIYVKKKSHIKLNTGVRAPFKAVDNINQQDEPTLIEGNNESSISSSTGDTFEEDFAY 79

  Fly   190 --KKELPE-----TKK----DSLEVKKDATRMPLIRGNSAVTTTTSTMPTTMSLSSKRLAGI--- 240
              |.|:.|     |.|    |.||.::.:...|    ...:|.....:||....:.:.||.:
pombe    80 QDKVEIEERSIRSTPKSIGDDDLENREGSFDAP----EGILTHGKHRLPTIPEWTKEDLAALSEA 140

  Fly   241 ----------EDIDANDKENLVLVSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLID 295
                      |||:.:..    :|.:|..:|:.|:..:|.:.....::::.|:|:....|.:|:|
pombe   141 AARLQANPSPEDIETDPS----MVPDYDPEIFHYMQSLERKLAPPPNYMSVQQEIDWVTRHMLVD 201

  Fly   296 WINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRTYLQLVGVTALFIATKYEELFPPAIGDFVF 360
            ||.:|.:.|.|..||..|||.:|||:|. :|......:||||::||.||.||||:.||:|.:|..
pombe   202 WIVQVQIHFRLLPETLFLAVNLIDRFLS-IKVVSLQKVQLVGLSALLIACKYEEIHPPSIYNFAH 265

  Fly   361 ITDDTYTARQIRQMELQIFKAIDCNLSRPLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEM 425
            :....:|..:|.:.|..:...:|.::|.|.|:.||||.|:|...:.:...::||..|:..:|...
pombe   266 VVQGIFTVDEIIRAERYMLMLLDFDISWPGPMSFLRRISRADSYDHDIRMLAKYLQEVTLMDEIF 330

  Fly   426 ATYRPSEIAAASLFLSLHLLNGNHRAGTGFNDRHWTPTLTFYSRYSAAHLRPITRLIAKLARDAP 490
            .....|.|||.:.:||:.:|        |..|  |||...:||.|:|..|:|...:|.:...|||
pombe   331 IGAHISFIAATAYYLSMQML--------GHLD--WTPCHVYYSGYTARQLKPCAIIIMECLVDAP 385

  Fly   491 QAKLKAIYNKYQGSKFQKIA 510
            ... .|||.||..::.::::
pombe   386 NHH-NAIYRKYSENRMKRVS 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	43/126 (34%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	39/122 (32%)
cig1	NP_588110.2	COG5024	1..414	CDD:227357	116/410 (28%)
		Cyclin_N	166..292	CDD:278560	43/126 (34%)
		Cyclin_C	294..408	CDD:281044	39/122 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	59	1.000	Domainoid score	I3040
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I1152
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	1	1.000	-	-		otm47210
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R194
SonicParanoid	1	1.000	-	-		X94
TreeFam	0	0.000	Not matched by this tool.
	10	9.790