DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycB and Ccnb1

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_741988.1	Gene:	Ccnb1 / 25203	RGDID:	2291	Length:	423	Species:	Rattus norvegicus

Alignment Length:	467	Identity:	167/467 - (35%)
Similarity:	244/467 - (52%)	Gaps:	61/467 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LKLTDALRNAKARVDSHWKKQPLGSTNGNGNGAVPPKVNEGGVSAFLRSNSVRNRVPTKTTVEPT 129
            |::|   ||.|...::..|....|:..      ||..|  ......|||.:....:..|.
  Rat     3 LRVT---RNTKINTENKAKVSMAGAKR------VPVAV--AASKPLLRSRTALGDIGNKV----- 51

  Fly   130 KVTVKSSSSENVNEPTLKREDSNLSKKSLTKLRAALAKPVMGVSGIRREPVAVSRKEAETKKELP 194
                    ||....| ||:|...|...::|.  .||.|||        :.|.|...|.|..:..|
  Rat    52 --------SEQSRIP-LKKETKKLGSGTVTV--KALPKPV--------DKVPVCEPEVELDEPEP 97

  Fly   195 ETKKDSLEVKKDATRMPLIRGNSAVTTTTSTMPTTMSLS---SKRLAGIEDIDANDKENLVLVSE 256
            |   ..:|||.....:.:...:.:...|:...|....|.   |..:..:.|:||:|..:..|.||
  Rat    98 E---PVMEVKHSPEPILVDTPSPSPMETSGCAPAEEYLCQAFSDVILAVSDVDADDGGDPNLCSE 159

  Fly   257 YVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRY 321
            ||.|||.||.|:|.||.:...:|.| :||:..|||:||||:.:|.::|.|..||..:.|:||||:
  Rat   160 YVKDIYAYLRQLEEEQSVRPKYLLG-REVTGNMRAILIDWLIQVQMKFRLLQETMYMTVSIIDRF 223

  Fly   322 LQVVKDT--KRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDC 384
            :|   |:  .:..||||||||:|||:||||::||.||||.|:|::|||..||||||::|.:.::.
  Rat   224 MQ---DSCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTNNTYTKHQIRQMEMKILRVLNF 285

  Fly   385 NLSRPLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLL-NGN 448
            :|.||||:|||||.||....:.|.||::||.:||:.:||:|..:.||:|||.:..|:|.:| ||
  Rat   286 SLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELSMLDYDMVHFAPSQIAAGAFCLALKILDNG- 349

  Fly   449 HRAGTGFNDRHWTPTLTFYSRYSAAHLRPITRLIAK--LARDAPQAKLKAIYNKYQGSKFQKIAL 511
                      .|||||..|..::...|.|:.:.:||  :..:....|...|.|||..||..||:.
  Rat   350 ----------EWTPTLQHYLSHTEESLLPVMQHLAKNIVMVNRGLTKHMTIKNKYATSKHAKIST 404

  Fly   512 RTELTGALMDSI 523
            ..:|...|:.::
  Rat   405 LAQLNCTLVQNL 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	65/128 (51%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	49/128 (38%)
Ccnb1	NP_741988.1	Interaction with CDK2. /evidence=ECO:0000250	159..167		6/7 (86%)
		Cyclin_N	163..288	CDD:278560	65/128 (51%)
		Interaction with CDK2. /evidence=ECO:0000250	248..251		2/2 (100%)
		Cyclin_C	290..408	CDD:281044	49/128 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340017
Domainoid	1	1.000	131	1.000	Domainoid score	I5055
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68982
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3316
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D475911at33208
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	1	1.000	-	-		oto96731
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900