DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycB and ccna2

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_694481.1	Gene:	ccna2 / 192295	ZFINID:	ZDB-GENE-020418-1	Length:	428	Species:	Danio rerio

Alignment Length:	509	Identity:	132/509 - (25%)
Similarity:	223/509 - (43%)	Gaps:	116/509 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KMRG--DENASENFKQVQLKKLTVPSMEATTKRAALGDLQNRGISRPIAAKDAAQKDSKDLKLTD 69
            ::||  .:|..||.:.|.      |:.:|...|..||:|:|            :|:....|:
Zfish    22 RLRGAAAKNRVENRENVN------PNPKAANNRTVLGELEN------------SQRRQLGLR--- 65

  Fly    70 ALRNAKARVDSHWKKQPLGSTNGNGNGAVPPKVNEGGVSAFLRSNSVRNRVPTKTTVEPTKVTVK 134
                              |:..|:|...:..|..|...|...|.:   ||.|....:
Zfish    66 ------------------GAKQGSGPQIIACKPEENARSFGERPS---NRQPAAFQI-------- 101

  Fly   135 SSSSENVNEPTLKREDSNLSKKSLTKLRAALAKPVMGVSGIRREPVAVSRKEAETKKELPETKKD 199
                 :|:||     |...|||      |.|.:..|..|.:...|.....::.....:||
Zfish   102 -----HVDEP-----DGACSKK------APLQRSTMDCSPLTLNPTVTRLRQPLATIDLP----- 145

  Fly   200 SLEVKKDATRMPLIRGNSAVTTTTSTMPTTMSLSSKRLAGIEDIDANDK-ENLVLVSEYVNDIYD 263
             ||...|:                   |..||:          ||..:: .|:..||:|..:|:.
Zfish   146 -LEASFDS-------------------PMDMSV----------IDCEERPTNVNEVSDYAAEIHT 180

  Fly   264 YLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDT 328
            :|.::|::......::..|.::::.|||:|:||:.||..::.|..||..|||..|||:|..: ..
Zfish   181 HLREMEVKSKPKAGYMRKQPDITNSMRAILVDWLVEVGEEYKLQNETLYLAVNYIDRFLSSM-SV 244

  Fly   329 KRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDCNLSRPLPIH 393
            .|..|||||..|:.:|:|:||::||.:.:||:|||||||.:|:.:||..:...:..:|:.|....
Zfish   245 LRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLTVLSFDLAAPTINQ 309

  Fly   394 FLRRYSKAAGAEDEHHTMSKYFIELASVDYE-MATYRPSEIAAASLFLSLHLLNGNHRAGTGFND 457
            ||.:|........:..::|.:..||:.:|.: ...|.||::|||:..|:      ||...:|
Zfish   310 FLTQYFLHQPVSSKVESLSMFLGELSLIDCDPFLKYLPSQMAAAAFILA------NHTLASG--- 365

  Fly   458 RHWTPTLTFYSRYSAAHLRPITRLIAKLARDAPQAKLKAIYNKYQGSKFQKIAL 511
             .|:.:|...:.||...|.|..:.:.:....|.|...:|:..||:|||:.:::|
Zfish   366 -SWSKSLVDLTGYSLEDLLPCVQDLHQTYLAASQHAQQAVREKYKGSKYHEVSL 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	47/126 (37%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	33/124 (27%)
ccna2	NP_694481.1	Cyclin_N2	33..157	CDD:293109	40/214 (19%)
		Cyclin_N	177..303	CDD:278560	47/126 (37%)
		Cyclin_C	305..422	CDD:281044	33/124 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579853
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.650