DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycB and Ccng2

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_031661.3	Gene:	Ccng2 / 12452	MGIID:	1095734	Length:	344	Species:	Mus musculus

Alignment Length:	231	Identity:	55/231 - (23%)
Similarity:	92/231 - (39%)	Gaps:	33/231 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 LSSKRLAGIEDIDANDKENLVLVSEYVNDIYDYLYQVELEQPIHKDHL------AGQKEVSHKMR 290
            |.:|.|||.|.:......|.            ||.|.:..||..|..:      .....:..::|
Mouse     4 LGAKHLAGGEGVQLFGLLNF------------YLEQEQRYQPREKGLILMEATPENDNTLCSRLR 56

  Fly   291 AVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRTYLQLVGVTALFIATKY--EELFPP 353
            ...::.:..:...|....|||.|||.|:||:|.::| .|..:|..:||....:|.:.  ||...|
Mouse    57 NAKVEDLRSLTNFFGSGTETFVLAVNILDRFLALMK-VKPKHLSCIGVCCFLLAARLAEEEGDVP 120

  Fly   354 AIGDFVFITDDTYTARQIRQMELQIFKAIDCNLSRPLPIHFLRRYSKAAGAEDEHHTMSKYFIEL 418
            ...|.:.|:....||..|::||..|.:.:...|.....::||..|......   |.:..|..:.|
Mouse   121 PTHDVIRISQCKCTASDIKRMEKIISEKLHYELEATTALNFLHLYHAIVFC---HTSERKEILSL 182

  Fly   419 ASVDYEM---------ATYRPSEIAAASLFLSLHLL 445
            ..::.::         :..|||.:|...|.|.:..:
Mouse   183 DKLEAQLKACNCRVVFSKARPSVLALCLLNLEIETI 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	35/134 (26%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	12/66 (18%)
Ccng2	NP_031661.3	Cyclin_N	<74..153	CDD:278560	27/79 (34%)
Ccng2	NP_031661.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..324
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836347
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830