DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycB and Ccnf

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	XP_006523617.1	Gene:	Ccnf / 12449	MGIID:	102551	Length:	790	Species:	Mus musculus

Alignment Length:	304	Identity:	72/304 - (23%)
Similarity:	136/304 - (44%)	Gaps:	31/304 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 SKRLAGIEDIDANDKENLVLVSEYVNDIYDYLYQVELEQPIHKDHL-AGQKEVSHKMRAVLIDWI 297
            :|..||...:....|    ..||.|..::      :..|.::|..: :.||.:|..||.:||||:
Mouse   276 AKACAGGSQLGLEGK----ACSESVCQLF------QASQAVNKQQIFSVQKGLSDTMRYILIDWL 330

  Fly   298 NEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRTYLQLVGVTALFIATKY--EELFPPAIGDFVF 360
            .||.......:....|.|..:||||: .:...|..|||:|:..:.|.|::  :|:.  .|.:.|:
Mouse   331 VEVATMKDFTSLCLHLTVECVDRYLR-RRLVPRYKLQLLGIACMVICTRFISKEIL--TIREAVW 392

  Fly   361 ITDDTYTARQIRQMELQIFKAIDCNLSRPLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEM 425
            :||:||....:.::..:|..|::..:..|..:.:................:..:..||..:...:
Mouse   393 LTDNTYKYEDLVRVMGEIISALEGKIRIPTVVDYKEVLLTLVPVAPRTQHLCSFLCELTLLHTSL 457

  Fly   426 ATYRPSEIAAASLFLSLHLLNGNHRAGTGFNDRHWTPTLTFYSRYSAAHLRPITRLIAK--LARD 488
            :.|.|:.:|:|:|.|: .|::|        ..:.||..|...:.:|.:.|.|....:.|  ...|
Mouse   458 SIYAPARLASAALLLA-RLMHG--------QTQPWTTHLWDLTGFSYSDLVPCVLSLHKKCFHDD 513

  Fly   489 AP----QAKLKAIYNKYQGSKFQKIALRTELTGALMDSIVGQSQ 528
            ||    |..|.|:..:::...:::|:....|:.|.:.|.:|..|
Mouse   514 APKDYRQVSLTAVKQRFEDKCYEEISREEVLSYADLCSTIGVKQ 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	35/129 (27%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	25/131 (19%)
Ccnf	XP_006523617.1	FBOX	48..86	CDD:197608
		Cyclin_N	296..419	CDD:365896	36/131 (27%)
		Cyclin_C	438..544	CDD:367282	24/114 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836363
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740