DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycB and CCNI

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001335061.1	Gene:	CCNI / 10983	HGNCID:	1595	Length:	377	Species:	Homo sapiens

Alignment Length:	187	Identity:	43/187 - (22%)
Similarity:	85/187 - (45%)	Gaps:	26/187 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 LAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRTYLQLVGVTALFI 343
            :...:.||...|..:|.|:.::..||:|..|||.||.:::||:|..||...: ||..:.::..|:
Human    34 MPSNQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPK-YLSCIAISCFFL 97

  Fly   344 ATK---YEELFPPAIGDFVFITDDTY---TARQIRQMELQIFKAIDCNLSRPLPIHFLRRYSKAA 402
            |.|   .:|..|.    ...:..|::   ::.:|.:||..|...::.:|....|:.||..:...|
Human    98 AAKTVEEDERIPV----LKVLARDSFCGCSSSEILRMERIILDKLNWDLHTATPLDFLHIFHAIA 158

  Fly   403 G-------------AEDEH-HTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLL 445
            .             :..:| ..::|..:...:.: ::..:|.|.:|.|.:.|.:..|
Human   159 VSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACN-QLLQFRGSMLALAMVSLEMEKL 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	30/113 (27%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	12/71 (17%)
CCNI	NP_001335061.1	Cyclin_N	34..142	CDD:365896	30/112 (27%)
CCNI	NP_001335061.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..377
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146229
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740