DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycB and ccnb2

DIOPT Version :9

Sequence 1:	NP_726244.1	Gene:	CycB / 37618	FlyBaseID:	FBgn0000405	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001138848.1	Gene:	ccnb2 / 100270772	XenbaseID:	XB-GENE-1005599	Length:	390	Species:	Xenopus tropicalis

Alignment Length:	487	Identity:	171/487 - (35%)
Similarity:	251/487 - (51%)	Gaps:	117/487 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 IAAKDAAQKDSKDLKLTDALRNAKARVDSHWKKQPLGSTNGNGNGAVPPKVNEGGVSAFLRSNSV 116
            :|.:.||.....|..|..|:| :||::::  ::..||..   ||     ||            :|
Frog     1 MATRRAAVSREADNILGGAMR-SKAQINT--RRAALGEI---GN-----KV------------TV 42

  Fly   117 RNRVPTKTTVEPTKVTVKSSSSENVNEPTLKREDSNLSKKSLTKLRAALAKPVMGVSGIRREPVA 181
            |.:.|   :|:|:.|..|.|                   |:.||  .|..||         :||.
Frog    43 RGKPP---SVKPSIVVAKPS-------------------KAATK--GANVKP---------KPVP 74

  Fly   182 VSRKEAETKKELPETKKDSLEVKKDATRMPLIRGNSAVTTTTSTMPTTMSLS--------SKRLA 238
            |....||...::|                             |.:|..:|:.        |..|.
Frog    75 VKTAVAEAPPKVP-----------------------------SPLPMDVSMKEEELCQAFSNALT 110

  Fly   239 GIEDIDANDKENLVLVSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQ 303
            .:|||||:|..|..|.|.||.|||:||.|:|::|.:...:|.| ||::.:|||:|:|||.:||.:
Frog   111 NVEDIDADDGGNPQLCSGYVMDIYNYLKQLEVQQSVRPCYLEG-KEINERMRAILVDWIVQVHSR 174

  Fly   304 FHLAAETFQLAVAIIDRYLQVVKDTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTA 368
            |.|..||..:.:||:||:|| |:...|:.|||||||:|.:|:||||::.|.:.|||:|||:.|||
Frog   175 FQLLQETLYMGIAIMDRFLQ-VQPVSRSKLQLVGVTSLLVASKYEEMYTPEVADFVYITDNAYTA 238

  Fly   369 RQIRQMELQIFKAIDCNLSRPLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEI 433
            .|||:||:.|.:.::.:|.||||:|||||.||:..|:.|.||::||.:||..:||||..:.||||
Frog   239 SQIREMEMIILRVLNFDLGRPLPLHFLRRASKSCSADAEQHTLAKYLMELTLIDYEMVHFNPSEI 303

  Fly   434 AAASLFLSLHLL-NGNHRAGTGFNDRHWTPTLTFYSRYSAAHLRPITRLIAKLARDAPQ--AKLK 495
            |||:|.||..:| .|:           |..|..:|:.|:.:.|:.:.:.:||......|  .|..
Frog   304 AAAALCLSQKILAQGS-----------WGATQHYYTGYTESDLQLVMKHMAKNLTKVNQNLTKHV 357

  Fly   496 AIYNKYQGSKFQKIA--------LRTELTGAL 519
            |:.|||..||..||:        |.|||:.:|
Frog   358 AVRNKYASSKLMKISTLPQLMAPLITELSASL 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB	NP_726244.1	Cyclin_N	260..387	CDD:278560	62/126 (49%)
CycB	NP_726244.1	Cyclin_C	389..515	CDD:281044	53/136 (39%)
ccnb2	NP_001138848.1	Cyclin_N2	<113..372	CDD:330468	125/271 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5007
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	241	1.000	Inparanoid score	I3249
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D475911at33208
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	1	1.000	-	-		otm48327
Panther	1	1.100	-	-	LDO	PTHR10177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070