DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blw and ATP5F1A

DIOPT Version :9

Sequence 1:	NP_726243.1	Gene:	blw / 37617	FlyBaseID:	FBgn0011211	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_016881278.1	Gene:	ATP5F1A / 498	HGNCID:	823	Length:	586	Species:	Homo sapiens

Alignment Length:	527	Identity:	435/527 - (82%)
Similarity:	479/527 - (90%)	Gaps:	5/527 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IFSARLASSVARNLPKAANQVACKAAYPAASLAARKLHVASTQ----RSAEISNILEERILGVAP 63
            :.|.|:|::|.|.||:.|..|: :.|..::.:|||..|.::|.    .:||:|:||||||||...
Human     1 MLSVRVAAAVVRALPRRAGLVS-RNALGSSFIAARNFHASNTHLQKTGTAEMSSILEERILGADT 64

  Fly    64 KADLEETGRVLSIGDGIARVYGLNNIQADEMVEFSSGLKGMALNLEPDNVGVVVFGNDKLIKQGD 128
            ..||||||||||||||||||:||.|:||:||||||||||||:||||||||||||||||||||:||
Human    65 SVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFGNDKLIKEGD 129

  Fly   129 IVKRTGAIVDVPVGDELLGRVVDALGNAIDGKGAINTKDRFRVGIKAPGIIPRVSVREPMQTGIK 193
            ||||||||||||||:||||||||||||||||||.|.:|.|.|||:||||||||:|||||||||||
Human   130 IVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGSKTRRRVGLKAPGIIPRISVREPMQTGIK 194

  Fly   194 AVDSLVPIGRGQRELIIGDRQTGKTALAIDTIINQKRFNEAQDESKKLYCIYVAIGQKRSTVAQI 258
            |||||||||||||||||||||||||::||||||||||||:..||.|||||||||||||||||||:
Human   195 AVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGSDEKKKLYCIYVAIGQKRSTVAQL 259

  Fly   259 VKRLTDSGAMGYSVIVSATASDAAPLQYLAPYSGCAMGEYFRDKGKHALIIYDDLSKQAVAYRQM 323
            ||||||:.||.|:::||||||||||||||||||||:|||||||.|||||||||||||||||||||
Human   260 VKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQM 324

  Fly   324 SLLLRRPPGREAYPGDVFYLHSRLLERAAKMSPAMGGGSLTALPVIETQAGDVSAYIPTNVISIT 388
            |||||||||||||||||||||||||||||||:.|.||||||||||||||||||||||||||||||
Human   325 SLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDAFGGGSLTALPVIETQAGDVSAYIPTNVISIT 389

  Fly   389 DGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTKAMKQVAGSMKLELAQYREVAAFAQFGSDLD 453
            ||||||||||||||||||||||||||||||||||:|||||||:||||||||||||||||||||||
Human   390 DGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFGSDLD 454

  Fly   454 AATQQLLNRGVRLTELLKQGQYVPMAIEDQVAVIYCGVRGHLDKMDPAKITKFEKEFLQHIKTSE 518
            |||||||:||||||||||||||.|||||:||||||.||||:|||::|:||||||..||.|:.:..
Human   455 AATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVVSQH 519

  Fly   519 QALLDTI 525
            ||||.||
Human   520 QALLGTI 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blw	NP_726243.1	PRK09281	46..552	CDD:236448	420/480 (88%)
		ATP-synt_ab_N	68..134	CDD:280947	59/65 (91%)
		F1_ATPase_alpha	136..417	CDD:238552	254/280 (91%)
		ATP-synt_ab_C	426..520	CDD:278722	76/93 (82%)
ATP5F1A	XP_016881278.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159285
Domainoid	1	1.000	411	1.000	Domainoid score	I680
eggNOG	1	0.900	-	-		E1_COG0056
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2985
Inparanoid	1	1.050	871	1.000	Inparanoid score	I420
Isobase	1	0.950	-	0	Normalized mean entropy	S65
OMA	1	1.010	-	-		QHG54695
OrthoDB	1	1.010	-	-		D186910at33208
OrthoFinder	1	1.000	-	-		FOG0002237
OrthoInspector	1	1.000	-	-		oto90421
orthoMCL	1	0.900	-	-		OOG6_100771
Panther	1	1.100	-	-	LDO	PTHR48082
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R117
SonicParanoid	1	1.000	-	-		X1480
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750