DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment blw and atp1

DIOPT Version :9

Sequence 1:	NP_726243.1	Gene:	blw / 37617	FlyBaseID:	FBgn0011211	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_594919.1	Gene:	atp1 / 2541526	PomBaseID:	SPAC14C4.14	Length:	536	Species:	Schizosaccharomyces pombe

Alignment Length:	521	Identity:	364/521 - (69%)
Similarity:	449/521 - (86%)	Gaps:	3/521 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PAASLAARKLHVASTQRSAEISNILEERILGVAPKADLEETGRVLSIGDGIARVYGLNNIQADEM 94
            |:.:|   |...|......|:.:||||||.|...:|.:.|:||||||||||||:.||:|:||:|:
pombe    19 PSITL---KRGYAEKAAPTEVPSILEERIRGAYNQAQMMESGRVLSIGDGIARISGLSNVQAEEL 80

  Fly    95 VEFSSGLKGMALNLEPDNVGVVVFGNDKLIKQGDIVKRTGAIVDVPVGDELLGRVVDALGNAIDG 159
            ||||||:||||||||.|.||.|:||||:|:::|::||||..|||||||:.|||||||||||.|||
pombe    81 VEFSSGIKGMALNLEADTVGCVLFGNDRLVREGEVVKRTRHIVDVPVGEALLGRVVDALGNPIDG 145

  Fly   160 KGAINTKDRFRVGIKAPGIIPRVSVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTALAIDT 224
            ||.|.|.:|.||.:|||||:||.||.||||||:||:||:|||||||||||||||||||||:|:||
pombe   146 KGPIKTTERRRVQLKAPGILPRTSVCEPMQTGLKAIDSMVPIGRGQRELIIGDRQTGKTAIALDT 210

  Fly   225 IINQKRFNEAQDESKKLYCIYVAIGQKRSTVAQIVKRLTDSGAMGYSVIVSATASDAAPLQYLAP 289
            |:|.||:|.:.||||||||:|||:|||||||||:|::|.::.::.||:||:||||::||||||||
pombe   211 ILNHKRWNNSSDESKKLYCVYVAVGQKRSTVAQLVQKLEENDSLKYSIIVAATASESAPLQYLAP 275

  Fly   290 YSGCAMGEYFRDKGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKM 354
            :|||||||:|||.|||.|::|||||||||||||||||||||||||||||||||||||||||||||
pombe   276 FSGCAMGEWFRDNGKHGLVVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKM 340

  Fly   355 SPAMGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSA 419
            ||..||||||||||||||.||||||||||||||||||||||:|||:|||||||||||||||||||
pombe   341 SPKHGGGSLTALPVIETQGGDVSAYIPTNVISITDGQIFLESELFFKGIRPAINVGLSVSRVGSA 405

  Fly   420 AQTKAMKQVAGSMKLELAQYREVAAFAQFGSDLDAATQQLLNRGVRLTELLKQGQYVPMAIEDQV 484
            ||.||||||||.:||.||||||||:||||||||||.|:..|:||:||||||||.||.|:|:|:||
pombe   406 AQVKAMKQVAGQIKLFLAQYREVASFAQFGSDLDAGTRATLDRGLRLTELLKQPQYSPLAVEEQV 470

  Fly   485 AVIYCGVRGHLDKMDPAKITKFEKEFLQHIKTSEQALLDTIAKDGAISEASDAKLKDIVAKFMST 549
            .:|||||:|:|||:...::.:||.:|:.::::|...:::.|.|:|.:|:.::..||.::.:|:|:
pombe   471 PLIYCGVKGYLDKIPVDRVVEFEHKFIPYLRSSGAEIMEAIRKEGVLSKTTEDSLKAVIKEFLSS 535

  Fly   550 F 550
            |
pombe   536 F 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blw	NP_726243.1	PRK09281	46..552	CDD:236448	360/505 (71%)
		ATP-synt_ab_N	68..134	CDD:280947	46/65 (71%)
		F1_ATPase_alpha	136..417	CDD:238552	229/280 (82%)
		ATP-synt_ab_C	426..520	CDD:278722	57/93 (61%)
atp1	NP_594919.1	PRK09281	33..536	CDD:236448	359/502 (72%)
		ATP-synt_ab_N	53..119	CDD:280947	45/65 (69%)
		F1_ATPase_alpha	122..403	CDD:238552	229/280 (82%)
		ATP-synt_ab_C	412..515	CDD:278722	59/102 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	385	1.000	Domainoid score	I125
eggNOG	1	0.900	-	-		E1_COG0056
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2985
Inparanoid	1	1.050	737	1.000	Inparanoid score	I88
OMA	1	1.010	-	-		QHG54695
OrthoFinder	1	1.000	-	-		FOG0002237
OrthoInspector	1	1.000	-	-		oto101488
orthoMCL	1	0.900	-	-		OOG6_100771
Panther	1	1.100	-	-	LDO	PTHR48082
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R117
SonicParanoid	1	1.000	-	-		X1480
TreeFam	1	0.960	-	-
	14	13.860