DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and Cnga1

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_445949.2	Gene:	Cnga1 / 85259	RGDID:	621815	Length:	683	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	218/462 - (47%)
Similarity:	307/462 - (66%)	Gaps:	13/462 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   550 QKPRRTASQRIRAATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAI 614
            :||:....:.       :|...|.||:|.:.|.|...:::..:||:.:||.|..|.|:....:..
  Rat   133 EKPKEKKEEE-------KKEVVVIDPSGNMYYNWLFCITLPVMYNWTMIIARACFDELQSDYLEY 190

  Fly   615 WFCLDYLSDFLYLIDILFHFRTGYLEDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIG 679
            |...||:||.:||.|:....||||||.|:|..|.|||...|..:..|.:|.|.::|.|.||...|
  Rat   191 WLIFDYVSDVVYLADMFVRTRTGYLEQGLLVKDKLKLIEKYKANLQFKLDVLSVIPTDLLYFKFG 255

  Fly   680 FN-SILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGS 743
            :| ..:|..||::|.|.:.|..|||..|||||:||.:.|:.|:::|.|||.|:|:.|.|..|||:
  Rat   256 WNYPEIRLNRLLRISRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVYYSISKAIGFGN 320

  Fly   744 RNWVY---HDSESADVVKQYLQSYYWCTLALTTIGDLPKPRSKGEYVFVILQLLFGLMLFATVLG 805
            ..|||   :|.|...:.::|:.|.||.||.|||||:.|.|....|||||::..|.|:::|||::|
  Rat   321 DTWVYPDVNDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVLDSEYVFVVVDFLIGVLIFATIVG 385

  Fly   806 HVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPD 870
            ::.:::::::|||.|||:::|.:|.||..|.|...::.:|||||||||..:|..||...:..|||
  Rat   386 NIGSMISNMNAARAEFQSRVDAIKQYMNFRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLRYLPD 450

  Fly   871 KLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRL 935
            ||:|||||||||||||:|.||.:.|||.|.||||:|:|.::|||||||:||::|:||||:..|:|
  Rat   451 KLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKL 515

  Fly   936 QVVADNGKTVMASLKAGSYFGEISILNM--GTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYP 998
            .||||:|.|....|..|||||||||||:  ..|||||||:::|:||||||.|||.|:.:.|.|||
  Rat   516 AVVADDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYP 580

  Fly   999 AARVRLE 1005
            .|:..||
  Rat   581 DAKTMLE 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	99/241 (41%)
		CAP_ED	890..1004	CDD:237999	69/115 (60%)
		DUF4655	1084..>1154	CDD:317882
Cnga1	NP_445949.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..144		2/17 (12%)
		Ion_trans	156..398	CDD:395416	98/241 (41%)
		P-helix. /evidence=ECO:0000250\|UniProtKB:Q00194	341..351		5/9 (56%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:Q00194	352..360		5/7 (71%)
		C-linker. /evidence=ECO:0000250\|UniProtKB:Q00194	393..475		45/81 (56%)
		CAP_ED	470..586	CDD:237999	69/115 (60%)
		Cyclic nucleotide-binding domain (CNBD). /evidence=ECO:0000250\|UniProtKB:Q00194	476..603		68/112 (61%)
		CLZ	586..655	CDD:406832	2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	124	1.000	Domainoid score	I5370
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820