DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and Cnga4

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_445948.2	Gene:	Cnga4 / 85258	RGDID:	619844	Length:	575	Species:	Rattus norvegicus

Alignment Length:	470	Identity:	197/470 - (41%)
Similarity:	292/470 - (62%)	Gaps:	6/470 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   554 RTASQRIRAATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCL 618
            :|......|.|.|||...|.||:|...|:|...:....:||..:::.|..|.::....:..||.|
  Rat     8 KTTESTPPAPTKARKWLPVLDPSGDYYYWWLNTMVFPIMYNLIIVVCRACFPDLQHSYLVAWFVL 72

  Fly   619 DYLSDFLYLIDILFHFRTGYLEDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFN-S 682
            ||.||.|||:||...|.||:||.|:|..|...:.:.|:.:..|.:|...|:|.|..|:.:|.: .
  Rat    73 DYTSDLLYLLDIGVRFHTGFLEQGILVVDKGMIASRYVRTWSFLLDLASLVPTDAAYVQLGPHIP 137

  Fly   683 ILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWV 747
            .||..|.:::.|.:...||||..|.|||.||...|:.|:.|:.|||.|||..:.:..|||...||
  Rat   138 TLRLNRFLRVPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWV 202

  Fly   748 YHDSESAD---VVKQYLQSYYWCTLALTTIGDLPKPRSKGEYVFVILQLLFGLMLFATVLGHVAN 809
            |.|.....   :.:|||.|:|:.||.|||:||.|.|..:.||:|::...|..:|.|||::|.:::
  Rat   203 YPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPLPDREEEYLFMVGDFLLAVMGFATIMGSMSS 267

  Fly   810 IVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKA 874
            ::.:::.|...|......||.||:::.|...|:.:||.|:.:|.:.:|.::|...:..||::|:|
  Rat   268 VIYNMNTADAAFYPDHALVKKYMKLQHVNKRLERRVIDWYQHLQINKKMTNEVAILQHLPERLRA 332

  Fly   875 EIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVA 939
            |:|::|||.||.||:||||.||..|.||||:|:|..:|||:|:||||::|:||||:..|:|.|||
  Rat   333 EVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGREMYIIREGQLAVVA 397

  Fly   940 DNGKTVMASLKAGSYFGEISILNM--GTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARV 1002
            |:|.|..|.|.||.|||||||:|:  ..:||||||:::|:||||||.|||:|:.:||.|||.|:.
  Rat   398 DDGVTQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQA 462

  Fly  1003 RLESIAVKRLEKYKK 1017
            .:|....:.|.|..|
  Rat   463 VMEEKGREILLKMNK 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	88/241 (37%)
		CAP_ED	890..1004	CDD:237999	69/115 (60%)
		DUF4655	1084..>1154	CDD:317882
Cnga4	NP_445948.2	Ion_trans	58..273	CDD:278921	82/214 (38%)
		P-loop_NTPase	116..>174	CDD:304359	21/57 (37%)
		IQ-type. /evidence=ECO:0000250	292..302		2/9 (22%)
		Crp	342..>519	CDD:223736	77/136 (57%)
		CAP_ED	348..464	CDD:237999	69/115 (60%)
		CLZ	464..535	CDD:293134	4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..575
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.780