DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42260 and Cnga3

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_008765264.1	Gene:	Cnga3 / 85257	RGDID:	70948	Length:	670	Species:	Rattus norvegicus

Alignment Length:	658	Identity:	256/658 - (38%)
Similarity:	357/658 - (54%)	Gaps:	123/658 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   481 AAQQAHHPYQLQHSASTVSHHPHAHGPP----------SQGGPGGPGPPHGGHPHHPHHGGAGSG 535
            ||:..||     ...:..|.....||..          :|..|||..||.||
  Rat    85 AARHLHH-----EDPTPDSFLDRFHGAELKEVSSQERNAQPNPGGQEPPEGG------------- 131

  Fly   536 GGSGPGSHGGQPHHQKPRRTASQRIRAATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIY 600
                           |.|             :|...|.||:..:.|.|...:::...||:.:::.
  Rat   132 ---------------KGR-------------KKDPIVVDPSSNIYYRWLTAIALPVFYNWCLLVC 168

  Fly   601 RFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFRTGYLEDGVLQTDALKLRTHYMNSTIFYIDC 665
            |..|.|:....:.:|..|||.:|.||::|:|...|||:||.|::..|..:|..||..:..|.:|.
  Rat   169 RACFDELQSEHLTLWLVLDYSADALYVVDMLVRARTGFLEQGLMVRDTKRLWKHYTKTLHFKLDI 233

  Fly   666 LCLLPLDFLYLSIGFN-SILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIFHWNG 729
            |.|:|.|..||.:|.| ..||..||::..|.:.|.||||..|||||:||...|:.|.|:|.|||.
  Rat   234 LSLIPTDLAYLKLGMNYPELRFNRLLRFSRLFEFFDRTETRTNYPNVFRIGNLVLYTLIIIHWNA 298

  Fly   730 CLYHIIHKNNGFGSRNWVYHDS---ESADVVKQYLQSYYWCTLALTTIGDLPKPRSKGEYVFVIL 791
            |:|..|.|..|||:.:|||.::   |...:.::|:.|.||.||.|||||:.|.|....||:||::
  Rat   299 CIYFAISKFIGFGTDSWVYPNTSKPEYGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVI 363

  Fly   792 QLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQ 856
            ..|.|:::|||::|:|.:::::::|:|.|||||:|.:|.||:.|:|...|:.:||:||||||..:
  Rat   364 DFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANR 428

  Fly   857 KCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKG 921
            |..||:..:..|||||||||||||||||||:|.|||:.|||.|.||||:|||.:||||||||:||
  Rat   429 KTVDEKEVLKNLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPAVFSPGDYICKKG 493

  Fly   922 EVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNM--GTAGNRRTASVRSVGYSDLFV 984
            ::|:||||:..|:|.||||:|.|....|..|||||||||||:  ..:||||||::||:||||||.
  Rat   494 DIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFC 558

  Fly   985 LSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAPL--------------------EKVKYFNVV 1029
            |||.|:.:.|.|||.|:..||       ||.::..:                    |||:|..
  Rat   559 LSKDDLMETLTEYPDAKRALE-------EKGRQILMKDNLIDDDLVTARADARNIEEKVEYLE-- 614

  Fly  1030 AMGRCQSTPGLVESCGRTSLEEMWLPPATAGASSLMHHHQALQQQHQASQ---QQPHRQESTQTS 1091
                 .|..||.....|                        |..::.|||   :|...|..:|.:
  Rat   615 -----SSLDGLQTRFAR------------------------LLAEYSASQMKLKQRLSQLESQMT 650

  Fly  1092 SQTHGYSP 1099
            .:.||:||
  Rat   651 RRGHGFSP 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	96/241 (40%)
		CAP_ED	890..1004	CDD:237999	72/115 (63%)
		DUF4655	1084..>1154	CDD:317882	6/16 (38%)
Cnga3	XP_008765264.1	Ion_trans	166..390	CDD:278921	92/223 (41%)
		Radical_SAM	423..>476	CDD:302752	35/52 (67%)
		Crp	456..>578	CDD:223736	76/121 (63%)
		CAP_ED	462..578	CDD:237999	72/115 (63%)
		CLZ	578..648	CDD:293134	18/107 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	124	1.000	Domainoid score	I5370
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920