DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42260 and KCNH6

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_110406.1	Gene:	KCNH6 / 81033	HGNCID:	18862	Length:	994	Species:	Homo sapiens

Alignment Length:	848	Identity:	187/848 - (22%)
Similarity:	323/848 - (38%)	Gaps:	242/848 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   509 SQGGPGGPGPPHGGHPHHPHHGGAGSGGGSGPGSHGG------------QPHHQKPRRTASQRI- 560
            |.|.||||||                  |:|.|.:..            :.:.:|.|.:::..|
Human   159 SHGRPGGPGP------------------GTGRGKYRTISQIPQFTLNFVEFNLEKHRSSSTTEIE 205

  Fly   561 ---------RAATAARKLHFVFD------PAGRL----------CYY------WSMVVSMAFLYN 594
                     |......|:..|..      |..:|          .:|      |..::.:..:|.
Human   206 IIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYT 270

  Fly   595 FWVIIYRFAF----QEINRRTIAIWFC-----LDYLSDFLYLIDILFHFRTGYL--EDGVLQTDA 648
            .....|..||    |:.:||....:.|     :|.:.|.::::||:.:|||.|:  .|.|: :..
Human   271 AVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVV-SHP 334

  Fly   649 LKLRTHYMNSTIFYIDCLCLLPLDFLYLS---------IGFNSILRSFRLVKIYRFWAFMDRTER 704
            .::..||.... |.||.:..:|.|.|...         ||.....|..|||::.|      :.:|
Human   335 RRIAVHYFKGW-FLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVAR------KLDR 392

  Fly   705 HTNYPNLFRSTALIHYLLVIF----HWNGCLYHII---------HKNNGFGSRNWV--------- 747
            ::.|     ..|::..|:..|    ||..|:::.|         ||      ..|:
Human   393 YSEY-----GAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEHK------IGWLDSLGVQLGK 446

  Fly   748 -YHDSESA---DVVKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVILQLLFGLMLFATVLGHV 807
             |:.|:.|   .|..:|:.:.|:...:||::| ....|.:..|.||.|..:|.|.:::|::.|:|
Human   447 RYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNV 511

  Fly   808 ANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKL 872
            :.|:..:.:....:..::..||.::|..::||.|:.::.::|.:.|......|....:...|:.|
Human   512 SAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECL 576

  Fly   873 KAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQV 937
            :|:|.:::|...|:....|.....|.|..|.::.:.....|||.:...|:|...:|.::||.:::
Human   577 QADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEI 641

  Fly   938 VADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARV 1002
            :.|:  .|:|.|.....|||  .:::.....:.:|.||::.|.||..:.:.|:.:||..|||.
Human   642 LRDD--VVVAILGKNDIFGE--PVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAF-- 700

  Fly  1003 RLESIAVKRLEKYKKAPLEKVKYFNV-VAMGRCQSTPGLVESCGRTSLEEMWLPPATAGASSLMH 1066
             .||...|         ||..  ||: .|.|...|:|.  ::.|....:..:|....:|:
Human   701 -AESFWSK---------LEVT--FNLRDAAGGLHSSPR--QAPGSQDHQGFFLSDNQSGS----- 746

  Fly  1067 HHQALQQQHQASQQQPHRQESTQTSSQTHGYSPRSYADRLARATDSPRSVSPSAHG--------- 1122
                   .|:...|.|.:           |||      .|...:.:.....|.|.|
Human   747 -------PHELGPQFPSK-----------GYS------LLGPGSQNSMGAGPCAPGHPDAAPPLS 787

  Fly  1123 ------------SEERPRSRTTSHHSIRPQSQPSHTGHICDSSSQLECYGAGVGGAGGGTTPL-L 1174
                        .|..||     |....||..|             :|:            || |
Human   788 ISDASGLWPELLQEMPPR-----HSPQSPQEDP-------------DCW------------PLKL 822

  Fly  1175 GSH-EVLEDEIKRLRERLHTVESENQALNTKLSQQ---QWDLE----NRLAEIEMQICGVSSTSS 1231
            ||. |.|:.::.||..|:.:..|....|..|...|   .:.||    |.||.:.:    .|.|:|
Human   823 GSRLEQLQAQMNRLESRVSSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPI----ASETTS 883

  Fly  1232 VDP 1234
            ..|
Human   884 PGP 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	67/290 (23%)
		CAP_ED	890..1004	CDD:237999	31/113 (27%)
		DUF4655	1084..>1154	CDD:317882	14/90 (16%)
KCNH6	NP_110406.1	PAS_9	29..132	CDD:290162
		PAS	41..132	CDD:238075
		Ion_trans	296..520	CDD:278921	58/242 (24%)
		Ion_trans_2	<463..517	CDD:285168	16/53 (30%)
		Selectivity filter. /evidence=ECO:0000250	476..481		1/4 (25%)
		Crp	588..>704	CDD:223736	33/122 (27%)
		CAP_ED	594..705	CDD:237999	33/117 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	720..790		15/100 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	880..946		3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910