DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and cnga2a

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001038211.1	Gene:	cnga2a / 751786	ZFINID:	ZDB-GENE-061005-1	Length:	673	Species:	Danio rerio

Alignment Length:	469	Identity:	228/469 - (48%)
Similarity:	311/469 - (66%)	Gaps:	8/469 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   562 AATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLY 626
            |.|..:...|:..||..|.|.|..|::.|.|||:..::.|..|.|:..|...:|..||||||.:|
Zfish   126 AKTKKKSDVFILSPADDLYYRWLFVIASAVLYNWCFVVARACFNELQTRNFILWLFLDYLSDVIY 190

  Fly   627 LIDILFHFRTGYLEDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFN-SILRSFRLV 690
            ::|.....|||:||.|:|..|.:|||..|.::..|.:|.|.::|.|..|:.||.: ..||..||:
Zfish   191 ILDTCVRLRTGFLEQGLLVKDLIKLRESYFHTLQFKLDLLSIIPTDLGYIVIGIHVPELRLNRLM 255

  Fly   691 KIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVY---HDSE 752
            :..|.:.|.||||..|:||||||...|:.|:|||.|||.|:|..|.|:.||||..|||   .|.:
Zfish   256 RFSRLFEFFDRTETRTSYPNLFRICNLVLYILVIIHWNACIYFAISKSLGFGSDQWVYPNISDPK 320

  Fly   753 SADVVKQYLQSYYWCTLALTTIGDLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAA 817
            ...:.:.|:...||.||.|||||::|.|....||:||:...|.|:::|||::|:|..::::::|.
Zfish   321 FGTLTRGYVYCLYWSTLTLTTIGEMPAPVQDEEYLFVVFDFLVGVLIFATIVGNVGAMISNMNAT 385

  Fly   818 RKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHL 882
            |.|||.::|.:|.||:.|:|...|:.:|||||||||..:|..||:..:..||:||:|||||||||
Zfish   386 RAEFQGQIDAIKHYMKFRKVSKELEARVIKWFDYLWTNKKTIDEQDVLKNLPNKLRAEIAINVHL 450

  Fly   883 DTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMA 947
            :|||:|.|||:.|||.|.||||:|||.:|||||||||||::||||||:..|.|.||||:|.|..|
Zfish   451 ETLKKVRIFQDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGCLAVVADDGVTQYA 515

  Fly   948 SLKAGSYFGEISILNM--GTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVK 1010
            .|.|||.||||||||:  ...||||||::||:||||||.|||.|:.:.:.|||.|:..||....:
Zfish   516 HLTAGSCFGEISILNIRGSKMGNRRTANIRSIGYSDLFCLSKGDLMEAVMEYPDAKKVLEEKGRQ 580

  Fly  1011 RLEKYKKAPLEKVK 1024
            .|  .|:..||:|:
Zfish   581 IL--IKEGLLEEVE 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	101/241 (42%)
		CAP_ED	890..1004	CDD:237999	74/115 (64%)
		DUF4655	1084..>1154	CDD:317882
cnga2a	NP_001038211.1	Ion_trans	162..386	CDD:278921	94/223 (42%)
		Ion_trans_2	<331..381	CDD:285168	22/49 (45%)
		Radical_SAM	407..>472	CDD:302752	39/64 (61%)
		Crp	452..>591	CDD:223736	84/140 (60%)
		CAP_ED	458..574	CDD:237999	74/115 (64%)
		CLZ	574..643	CDD:293134	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5401
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920