DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42260 and HCN2

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001185.3	Gene:	HCN2 / 610	HGNCID:	4846	Length:	889	Species:	Homo sapiens

Alignment Length:	817	Identity:	196/817 - (23%)
Similarity:	327/817 - (40%)	Gaps:	192/817 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 SASTVSHHPH---AHGPPSQGGPGGPGPPHGGHPHHPHHGGAGSGGGSGPG----------SHGG 545
            :|||....|:   ..|.| |..|.||..|..|........||.||...|||          ...|
Human    90 AASTAKGSPNGECGRGEP-QCSPAGPEGPARGPKVSFSCRGAASGPAPGPGPAEEAGSEEAGPAG 153

  Fly   546 QPH----------------------------HQKPRRTASQRIRAATAARKLHFVFDPAGRLCYY 582
            :|.                            .||......:|:::|.|     ::..|.....:|
Human   154 EPRGSQASFMQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGA-----WIIHPYSDFRFY 213

  Fly   583 WSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFRTG-YLEDGV-LQ 645
            |...:.:..:.|..:|.....|  ....|.|.|...:.:||..:|:|::.:|||| .:||.. :.
Human   214 WDFTMLLFMVGNLIIIPVGITF--FKDETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEII 276

  Fly   646 TDALKLRTHYMNSTIFYIDCLCLLPLDFLYL------------------SIGFNSILRSFRLVKI 692
            .|..|::..|:. |.|.:|.:..:|:|:::|                  .:.|..||...||:::
Human   277 LDPEKIKKKYLR-TWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRL 340

  Fly   693 YRFWAFMDRTER--HTNY---PNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVYHDSE 752
            .|...::.:.|.  |..|   ..:.|...||..:|::.||:|||..::.....|....||   |.
Human   341 SRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWV---SI 402

  Fly   753 SADVVKQYLQSYYWCTLA----LTTIG-DLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVT 812
            :..|...:.:.|.:....    :..|| ....|.|..:....:|.::.|...:|..:||...::.
Human   403 NGMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQ 467

  Fly   813 SVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIA 877
            |:.::|:::|.|...|:.||...::|...:.|:..::::.: ..|..||:..:..|...|:.||
Human   468 SLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY-QGKMFDEDSILGELNGPLREEI- 530

  Fly   878 INVHLDTL-KRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADN 941
            :|.:...| ..:.:|.|.:..|:..::.:|:..:|.|||||.|:|.:||:||.:..|.:.|:...
Human   531 VNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG 595

  Fly   942 GKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLES 1006
            .|.:  .|..|||||||.:|..|    |||||||:..|..|:.||..:..:||:|||..|...|:
Human   596 NKEM--KLSDGSYFGEICLLTRG----RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFET 654

  Fly  1007 IAVKRLEKYKKAP---LEKVKYFNVVAMGRCQSTPGLVESCGRTSLEEMWLPPATAGASSLMHHH 1068
            :|:.||::..|..   |.||::         ....|:..:.....::|            ::.:.
Human   655 VAIDRLDRIGKKNSILLHKVQH---------DLNSGVFNNQENAIIQE------------IVKYD 698

  Fly  1069 QALQQQHQASQQ------QPHRQESTQTSSQTHGYSPRSYADRLAR------ATDSPRSV----- 1116
            :.:.||.:..|:      .|...:.|...:.....:..|:..::||      |..|||.|
Human   699 REMVQQAELGQRVGLFPPPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPP 763

  Fly  1117 -------SP------SAHGSEERPRSRTTSHH--------------------SIRP--QSQPS-- 1144
                   ||      |..|:...||:..||.:                    :.||  .||||
Human   764 GPAPAAASPGPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQPSLP 828

  Fly  1145 HTGHICDSSSQLECYGAGVGGAGGGT------TPLLG 1175
            |                |..|....|      ||.||
Human   829 H----------------GAPGPAASTRPASSSTPRLG 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	61/267 (23%)
		CAP_ED	890..1004	CDD:237999	46/113 (41%)
		DUF4655	1084..>1154	CDD:317882	24/117 (21%)
HCN2	NP_001185.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..159		21/69 (30%)
		Involved in subunit assembly. /evidence=ECO:0000250	158..209		6/55 (11%)
		Ion_trans_N	167..209	CDD:285597	6/46 (13%)
		Ion_trans	229..474	CDD:278921	58/250 (23%)
		Crp	538..>673	CDD:223736	53/140 (38%)
		CAP_ED	544..652	CDD:237999	46/113 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..889		26/112 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910