DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42260 and Hcn4

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_067690.1	Gene:	Hcn4 / 59266	RGDID:	71065	Length:	1198	Species:	Rattus norvegicus

Alignment Length:	889	Identity:	219/889 - (24%)
Similarity:	352/889 - (39%)	Gaps:	196/889 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 NKSRGRLKTAASGDQPLLGTWNRSTGRGSQDN----------TLAGGGATSLAMGGHNQYG---- 458
            ::|||....||..:.|     .||.|:.|.:.          :|...|..|...||.:..|
  Rat    65 SESRGAALGAADSEGP-----GRSAGKSSTNGDCRRFRGSLASLGSRGGGSGGAGGGSSLGHLHD 124

  Fly   459 -----------GNYCNGTDRYPRSRSQQQGHHNAAQQAHHPYQLQHSASTVSHHPHAHGPPSQGG 512
                       |:...|.||.|...:.:.....||.|                 |.|..||.|
  Rat   125 SAEERRLIAAEGDASPGEDRTPPGLATEPERPGAAAQ-----------------PAASPPPQQ-- 170

  Fly   513 PGGPGPPHGGHPHHPH-------HGGAGSG-----------GGSG-----------PGSH----- 543
               |..|.......|.       .|||.:.           |.||           ||.:
  Rat   171 ---PPQPASASCEQPSADTAIKVEGGAAASDQILPEAEVRLGQSGFMQRQFGAMLQPGVNKFSLR 232

  Fly   544 --GGQPHHQKPRRTASQRIRAATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQE 606
              |.    ||......:|:::|.     .::..|.....:||.:.:.:..:.|..:|.....|.:
  Rat   233 MFGS----QKAVEREQERVKSAG-----FWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFK 288

  Fly   607 INRRTIAIWFCLDYLSDFLYLIDILFHFRTG-YLEDGV-LQTDALKLRTHYMNSTIFYIDCLCLL 669
            ....|  .|...:.:||..:|||::.:|||| .:||.. :..|..:::..|:.|. |.:|.:..:
  Rat   289 DENTT--PWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSW-FVVDFISSI 350

  Fly   670 PLDFLYL------------------SIGFNSILRSFRLVKIYRFWAFMDRTER--HTNY---PNL 711
            |:|:::|                  .:.|..||...||:::.|...::.:.|.  |..|   ..:
  Rat   351 PVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAV 415

  Fly   712 FRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWV-YHDSESADVVKQYLQSYYWCTLALTTIG 775
            .|...||..:|::.||:|||..::.....|....|| .:...:....|||..:.:.....:..||
  Rat   416 VRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCWVSINGMVNNSWGKQYSYALFKAMSHMLCIG 480

  Fly   776 -DLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPN 839
             ....|....:....:|.::.|...:|..:||...::.|:.::|:::|.|...|:.||...::|.
  Rat   481 YGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPP 545

  Fly   840 HLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTL-KRVEIFQNTEAGFLCELV 903
            ..:.::..::::.: ..|..|||..:..|.:.|:.|| ||.:...| ..:.:|.|.:..|:..::
  Rat   546 DTRQRIHDYYEHRY-QGKMFDEESILGELSEPLREEI-INFNCRKLVASMPLFANADPNFVTSML 608

  Fly   904 LRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGN 968
            .:||..:|.|||||.|:|.:||:||.:..|.:.|:....|.  ..|..|||||||.:|..|
  Rat   609 TKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKE--TKLADGSYFGEICLLTRG---- 667

  Fly   969 RRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAP---LEKVKY----- 1025
            |||||||:..|..|:.||..:..:||:|||..|...|::|:.||::..|..   |.||::
  Rat   668 RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSG 732

  Fly  1026 -FN---------VV----AMGRCQSTPGLVESCGRTSLEEMWLP---------PATAGASSLMHH 1067
             ||         :|    .|..|........|...|....:|.|         .||...:..:.|
  Rat   733 VFNYQENEIIQQIVRHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTH 797

  Fly  1068 HQALQQQHQASQQQPHRQESTQTSSQTHGYSPRSYADRLARATDSPRSVSPSAHGSEERPRSRTT 1132
            |..|    .|:..:|  .......:...|.:|| :..||       :|:.|||.||..
  Rat   798 HPRL----PAAIFRP--PPGPGLGNLGAGQTPR-HPRRL-------QSLIPSALGSAS------- 841

  Fly  1133 SHHSIRPQSQPSHTGHICDSSSQLECYGAGVGGAGGGTTPLLGS 1176
                  |.|.||.......||..::.. ||. .|..|.:|||.|
  Rat   842 ------PASSPSQVDTPSSSSFHIQQL-AGF-SAPPGLSPLLPS 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	59/264 (22%)
		CAP_ED	890..1004	CDD:237999	47/113 (42%)
		DUF4655	1084..>1154	CDD:317882	16/69 (23%)
Hcn4	NP_067690.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..183		31/144 (22%)
		Involved in subunit assembly. /evidence=ECO:0000250	209..260		11/59 (19%)
		Ion_trans_N	218..260	CDD:400630	8/50 (16%)
		PLN03192	253..>740	CDD:215625	135/497 (27%)
		CAP_ED	595..703	CDD:237999	47/113 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	804..1198		26/99 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3503
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.960