DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and cnga1b

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_701036.4	Gene:	cnga1b / 572249	ZFINID:	ZDB-GENE-110408-39	Length:	639	Species:	Danio rerio

Alignment Length:	459	Identity:	227/459 - (49%)
Similarity:	307/459 - (66%)	Gaps:	6/459 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   572 VFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFRT 636
            |.||||.:.|.|..|::...:||:..||.|..|:|:....:.:||.||||||.:||:|::|..||
Zfish   113 VVDPAGNMYYNWLFVITCPVMYNWIFIIARACFEELQGDYLILWFFLDYLSDAVYLLDMVFRTRT 177

  Fly   637 GYLEDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFN-SILRSFRLVKIYRFWAFMD 700
            ||||.|:|..|..|||..|.:|..|.:|...::|.|..||..|.| ..:|..:|::|.|.:.|..
Zfish   178 GYLEQGLLVKDQKKLRDRYTDSLQFRLDLASMVPTDIFYLYFGMNYPEIRMNKLLRINRLFEFFQ 242

  Fly   701 RTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVY---HDSESADVVKQYLQ 762
            |||..||:||:||.:.|:.|:::|.|||.|:|:...|..||||..:||   .|.|...:|::|..
Zfish   243 RTETRTNFPNVFRISNLVMYIVIIIHWNACMYYSFSKAIGFGSDAFVYPDPSDPEFGRLVRKYAY 307

  Fly   763 SYYWCTLALTTIGDLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDG 827
            |.||.||.|||||:.|.|....||.||:...|.|:::|||::|:|.:::|:.:|||.:|||::|.
Zfish   308 SMYWSTLTLTTIGETPPPVENSEYFFVVTDFLVGVLIFATIVGNVGSMITNANAARADFQARIDA 372

  Fly   828 VKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQ 892
            :|.||..|:|...|:.:|||||||||..:|..||...:..|||||:|||||||||||||:|.||.
Zfish   373 IKQYMSFRKVTKDLEKRVIKWFDYLWTNKKAVDEREVLKYLPDKLRAEIAINVHLDTLKKVRIFA 437

  Fly   893 NTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGE 957
            :.|||.|.||||:|:|.::|||||||:||::|:||||:..|:|.||||:|.|....|..||||||
Zfish   438 DCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGSYFGE 502

  Fly   958 ISILNM--GTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAPL 1020
            |||||:  ..|||||||::||:||||||.|||.|:.:.|.|||.|:..||....:.|.|.....|
Zfish   503 ISILNIKGSRAGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPDAKAMLEEKGRQILMKDNLLDL 567

  Fly  1021 EKVK 1024
            |..|
Zfish   568 ELAK 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	103/241 (43%)
		CAP_ED	890..1004	CDD:237999	70/115 (61%)
		DUF4655	1084..>1154	CDD:317882
cnga1b	XP_701036.4	Ion_trans	151..363	CDD:278921	92/211 (44%)
		Crp	429..629	CDD:223736	81/143 (57%)
		CAP_ED	435..551	CDD:237999	70/115 (61%)
		CLZ	551..621	CDD:293134	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5401
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.820