DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and kcnh4b

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_017213998.1	Gene:	kcnh4b / 567442	ZFINID:	ZDB-GENE-121214-54	Length:	1193	Species:	Danio rerio

Alignment Length:	744	Identity:	175/744 - (23%)
Similarity:	309/744 - (41%)	Gaps:	155/744 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   565 AARKLHFVFDPAGRLCYY------WSMVVSMAFLYNFWVIIYRFAF------QEINRRTIAIWFC 617
            |.:|..|:      |.:|      |..::.:|..|....:.|...|      :...|.||.
Zfish   205 AVQKSRFI------LLHYSVSKALWDWMILLATFYVAVTVPYNVCFTAYSDVETAGRSTIV---- 259

  Fly   618 LDYLSDFLYLIDILFHFRTGYL-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLY-LSIGF 680
            .|...:.|:::||:.:|||.|: :.|.:..:...:..||. :|.|::|.:..||.|.|| .:|..
Zfish   260 SDIAVEMLFILDIILNFRTTYVSQSGQVVYEPRSICLHYA-TTWFFVDLVAALPFDLLYAFNITV 323

  Fly   681 NSILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHIIHKN------N 739
            .|::...:.|::.|....:.:.:|::.|..:. .|.|:....::.||..|:::||.:.      :
Zfish   324 TSLVHLLKTVRLLRLLRLLQKLDRYSQYSAMV-LTLLMSMFALLAHWMACIWYIIGRKEMETNAS 387

  Fly   740 GFGSRNWVYHDSESAD------------VVKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVIL 791
            |.....|::...:..|            |...|:.|.|:...:||::| ......:..|.:|.:.
Zfish   388 GAWDIGWLHELGKRLDKPYMNSTFGGPSVRSAYIASLYFTLSSLTSVGFGNVCANTDAEKIFSVC 452

  Fly   792 QLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQ 856
            .:|.|.::.|.|.|:|..|:..:.:.|..:..::..:|.::|:.|:|..|:.:::::|...|...
Zfish   453 TMLIGALMHAVVFGNVTAIIQRMYSRRSLYHTRMKDLKDFIRVHRLPQQLKQRMLEYFQTTWSVN 517

  Fly   857 KCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKG 921
            ...|....:...||:|:|:||::::.|.| ::.:|:....|.|..|.|.::....:||:|:.|:|
Zfish   518 NGIDVNELLHDFPDELRADIAMHLNKDIL-QLPVFEAASRGCLRSLSLHIKTSFCTPGEYLIRQG 581

  Fly   922 EVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLS 986
            :..:..|.|..|.|:|:.||  .|:|.|..|...|  |.|.......:..|.|:::.|.||..:.
Zfish   582 DALQANYFVCSGSLEVLKDN--MVLAILGRGDLIG--SDLPGQNHVIKTNADVKALTYCDLQYIG 642

  Fly   987 KKDMWDVLKEYPAARVRLESIAVKR----------------------LEKYKKAPLEKV----KY 1025
            .|.:.|||:.|| ....:.:|.:.|                      .|..:.:.:||.    ||
Zfish   643 VKGLSDVLELYP-EYANIFTIDIHRNLTYNLREGSETEQNYPDFSVSTENKRPSVVEKADDPDKY 706

  Fly  1026 FNV-VAMGRCQS--TPGLVESCGRTSL-----EEM---------------WLP-PATAGASSLMH 1066
            |:| .|...|::  .|.|.....||||     ||:               |.| |:....|.
Zfish   707 FHVSSASSTCRNLLLPNLGSPVRRTSLGNLLGEELMQFNALRHCRSPVRGWSPNPSPKPPSK--- 768

  Fly  1067 HHQALQQQHQASQQQPHRQESTQTSSQTHGYSPRSYADRLARATD--SPRSVSPS-AHGSEERPR 1128
                :|:|.|.....|.....|||.|   |...|..|..|....:  .|..:||. ..|.|:
Zfish   769 ----VQKQTQQPSSTPKPIHKTQTDS---GSMARKPAKLLIPTLNCFGPPDLSPRVVDGIED--- 823

  Fly  1129 SRTTSHHSIRPQSQPSHTGHIC-----DSSSQLECYGAGVGGAGGGTTPLLGSHEV---LEDEIK 1185
                             .||:.     |:|::      |.......:..|.||.:|   |..|.|
Zfish   824 -----------------NGHVFQFNVEDTSTK------GTTETSQSSKTLDGSGQVNVSLLQETK 865

  Fly  1186 RLRERLHTVESENQALNTKLSQQQWDLEN 1214
            .:||   |::.    ||.|:...:.::.|
Zfish   866 EVRE---TIDQ----LNKKMGNLKEEVAN 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	60/270 (22%)
		CAP_ED	890..1004	CDD:237999	35/113 (31%)
		DUF4655	1084..>1154	CDD:317882	16/77 (21%)
kcnh4b	XP_017213998.1	PAS_9	29..135	CDD:290162
		PAS	42..133	CDD:238075
		Ion_trans	261..480	CDD:278921	51/220 (23%)
		Ion_trans_2	<420..474	CDD:285168	15/53 (28%)
		Crp	547..>668	CDD:223736	37/125 (30%)
		CAP_ED	550..660	CDD:237999	35/114 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910