DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and cnga3a

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_005166141.1	Gene:	cnga3a / 567242	ZFINID:	ZDB-GENE-090611-2	Length:	765	Species:	Danio rerio

Alignment Length:	458	Identity:	220/458 - (48%)
Similarity:	301/458 - (65%)	Gaps:	14/458 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   571 FVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFR 635
            ::.|||....|.|..:::....||..:::.|..|.|:......:|..|||.||.:|.:|.....|
Zfish   232 WIMDPASDKYYRWLSIIAAPVFYNLMMLVTRACFNELQNTYTILWIVLDYTSDVIYYMDTFVRSR 296

  Fly   636 TGYLEDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFNS-ILRSFRLVKIYRFWAFM 699
            ||:||.|:|..|:.||..:|.....|..|.:.::|.|...|.:|||: .||..||.|:.|.:.|.
Zfish   297 TGFLEQGLLVKDSKKLINNYRTIPQFKYDMISMIPTDLFMLKVGFNNPELRFNRLFKMARLFEFF 361

  Fly   700 DRTERHTNYPNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVYHD---SESADVVKQYL 761
            ||||..|||||:||.:.|:.|:|||.|||.|::..|.|..|||:..|||.:   .|...:.::|:
Zfish   362 DRTETRTNYPNIFRISNLVLYILVIIHWNACIFFAISKTIGFGTDTWVYPNISHPEYGRLARKYI 426

  Fly   762 QSYYWCTLALTTIGDLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLD 826
            ...||.||.|||||:.|.|....||:||::..|.|:::|||::|:|..::::::|:|.|||||:|
Zfish   427 YCLYWSTLTLTTIGETPPPVRDIEYLFVVMDFLIGVLIFATIVGNVGAMISNMNASRAEFQAKID 491

  Fly   827 GVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIF 891
            .:|.||:.|:|...|:.:|||||||||..:|..||:..:..|||||||||||||||||||:|.||
Zfish   492 SIKQYMQFRKVSKDLEARVIKWFDYLWTEKKTCDEKEVLKNLPDKLKAEIAINVHLDTLKKVRIF 556

  Fly   892 QNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFG 956
            |:.|||.|.||||:|:|.:||||||||:||::|:||||:..|:|.||||:|.|....|..|:|||
Zfish   557 QDCEAGLLIELVLKLQPQVFSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGAYFG 621

  Fly   957 EISILNM--GTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAP 1019
            |||||.:  ..|||||||::|||||||||.|||.|:.:.|.|||.|:        |.||:..||.
Zfish   622 EISILGIKGSKAGNRRTANIRSVGYSDLFALSKDDLVEALTEYPDAK--------KALEEKGKAI 678

  Fly  1020 LEK 1022
            |.|
Zfish   679 LRK 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	94/241 (39%)
		CAP_ED	890..1004	CDD:237999	71/115 (62%)
		DUF4655	1084..>1154	CDD:317882
cnga3a	XP_005166141.1	Ion_trans	272..483	CDD:278921	87/210 (41%)
		Crp	549..>671	CDD:223736	76/129 (59%)
		CAP_ED	555..671	CDD:237999	72/123 (59%)
		CLZ	671..741	CDD:293134	6/11 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5401
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.820