DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and kcnh2a

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_021336554.1	Gene:	kcnh2a / 563802	ZFINID:	ZDB-GENE-070912-699	Length:	1254	Species:	Danio rerio

Alignment Length:	812	Identity:	173/812 - (21%)
Similarity:	317/812 - (39%)	Gaps:	191/812 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   583 WSMVVSMAFLYNFWVIIYRFAF------QEINRR------TIAIWFCLDYLSDFLYLIDILFHFR 635
            |..|:.:..:|......|..||      :|:.:|      |:.:   :|.:.|.::::||:.:||
Zfish   408 WDWVILLLVIYTAIFTPYSAAFLLSDEEEEVIQRCGYSCSTLNV---VDLIVDIMFVVDIVINFR 469

  Fly   636 TGYL--EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFL-YLS----------IGFNSILRSF 687
            |.|:  .|.|:.... ::..||.... |.||.:..:|.|.| |.|          ||.....|..
Zfish   470 TTYVNSNDEVVSQPG-RIAVHYFKGW-FLIDMVAAIPFDLLIYRSEEETTTSTTLIGLLKTARLL 532

  Fly   688 RLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCLYHIIH--KNNGFGSRNW 746
            |||::.|      :.:|::.|     ..|::..|:..|    ||..|:::.|.  :.:|.....|
Zfish   533 RLVRVAR------KLDRYSEY-----GAAVLFLLMCTFALIAHWLACIWYAIGNVERSGPSRIGW 586

  Fly   747 V----------YHDS---ESADVVKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVILQLLFGL 797
            :          |:.|   ....:..:|:.:.|:...:||::| ....|.:..|.:|.|..:|.|.
Zfish   587 LNSLGDQLGKPYNSSVRGSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGA 651

  Fly   798 MLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEE 862
            :::|::.|:|:.|:..:.:....:..::..|:.::|..::||.|:.::.::|.:.|......|..
Zfish   652 LMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMN 716

  Fly   863 RAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEM 927
            ..:...|:.|:|:|.::::...|:..:.|:.:..|.|..|.::.:.....|||.:...|:|...:
Zfish   717 AVLKGFPECLQADICLHLNRTLLQSCKAFKGSSKGCLRALAMKFKTTHAPPGDTLVHAGDVISAL 781

  Fly   928 YIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWD 992
            |.::||.::::  .|..|:|.|.....|||  .:|......:.:|.||::.|.||..:.:.|:.:
Zfish   782 YFISRGSIEIL--KGDVVVAILGKNDIFGE--PINSYARPGKSSADVRALTYCDLHKIHRDDVLE 842

  Fly   993 VLKEYPAARVRLESIAVKRLEKYKKAPLEKVKYFNV----VAMGRCQSTPGLVESCG-------- 1045
            ||:.||            ....|..:.||..  ||:    ...|...|.|...::.|
Zfish   843 VLEMYP------------EFSDYFWSNLEIT--FNLRDTNTKAGSMSSDPDDSDNGGLDHHTRRA 893

  Fly  1046 -----------------RTS--LEEMWLPPATAGASSLMHHHQALQQQHQ-----ASQQQPHRQE 1086
                             ||.  |..|.....|:|     ..|:..|..|:     |||.....:|
Zfish   894 KLFFQSKRNSISRADTERTEDRLNRMTFRTQTSG-----KQHENRQTAHRSSDIFASQSSSDEEE 953

  Fly  1087 STQ------TSSQTHGYS-PRSYADRLARATDSPRSVSP---------SAHGSEERPRSRTTSHH 1135
            .||      ..||:|..| ..:..|:...:::|..::|.         |..|...|      .||
Zfish   954 ETQRPSVMVDCSQSHINSVSNANRDKDHNSSNSFNALSGAFSGVSNIFSLWGDSSR------GHH 1012

  Fly  1136 SIRPQSQPSHTGHICDSSSQLECYGAGVGGAGGGTTPLLGSHEVLEDEIKRLRERLHTVESENQA 1200
            .   |..|||:.....||..             ..|.|   |.|...:...:..||..:..:...
Zfish  1013 Y---QEVPSHSMSFPSSSVP-------------SNTVL---HNVTYGQCSEVENRLEMMHRQLYR 1058

  Fly  1201 LNTKLSQQ----QWDLENRLAEIEMQICGVSSTSSVDP---------ENETEELERNRESIIXHG 1252
            |..::|:.    ...|:.::.::......|:|.:...|         ......||....||:  .
Zfish  1059 LEKRMSKDIGAIMQLLQRQMVQVPPAYSSVTSPTEASPIPPKPGQKLVQPVNPLETETPSIL--S 1121

  Fly  1253 SVL-PHQ--------------AIGMVYISCSS 1269
            .:| ||.              |:.:..:.|||
Zfish  1122 EILDPHDFADSPIKASESLSGAMELQLLDCSS 1153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	64/280 (23%)
		CAP_ED	890..1004	CDD:237999	31/113 (27%)
		DUF4655	1084..>1154	CDD:317882	20/85 (24%)
kcnh2a	XP_021336554.1	PAS_9	29..130	CDD:315989
		Ion_trans	407..670	CDD:306908	64/277 (23%)
		CAP_ED	744..855	CDD:237999	32/126 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910