DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and hcn3

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_689197.1	Gene:	hcn3 / 560709	ZFINID:	ZDB-GENE-060503-193	Length:	639	Species:	Danio rerio

Alignment Length:	655	Identity:	170/655 - (25%)
Similarity:	280/655 - (42%)	Gaps:	102/655 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   417 AASGDQPLLGTWNRS-TGRGSQDNTLAGGGATS-----LAMGGHNQYGGNYCNGTDRYPRSRSQQ 475
            |::||..|......| ||..|...||..|.|..     |::..|||...:  :|.....:|....
Zfish     9 ASNGDSKLRSRGGFSLTGWRSSSKTLLRGEAEDVSRRLLSIVNHNQERSD--SGASPTSKSLEVT 71

  Fly   476 QGHHNAAQQAHHPYQLQHSASTVSHH----PHAHGPPSQGGPGGPGPPHGGHPHHPHHGGAGSGG 536
            .|......          :.:||:..    ||...|.|.|.|                  ..|..
Zfish    72 AGLDGTTA----------TTTTVTAATPPLPHKAMPESSGAP------------------VASEA 108

  Fly   537 GSGP-----------GSHGGQPHHQK--PRRTASQRIRAATAARKLHF---VFDPAGRLCYYWSM 585
            ..||           .|...||...|  .|...|.:..||...|...|   :..|.....:||.:
Zfish   109 EDGPFVDQSTFLQRQFSSMLQPGVNKFSLRMFGSAKGVAAEQDRVKSFGVWIIHPYSDFRFYWDL 173

  Fly   586 VVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFRTGYLE--DGVLQTDA 648
            |:....:.|..::.:...|.| ::.|:. |...:..||.|:|.|::|:||||.:|  :..:..|.
Zfish   174 VMLCLMMGNLVILPWGITFFE-DQNTLP-WITFNVASDTLFLADLVFNFRTGIMEGDNSEIILDP 236

  Fly   649 LKLRTHYMNSTIFYIDCLCLLPLDFLYLSIG---------------------FNSILRSFRLVKI 692
            ..:...|:... |.:|.:..:|:|:::|.:.                     |..||...||:::
Zfish   237 QIISRRYLRGW-FLVDFISSIPVDYIFLIVDIESRLESAEVYRTARALRIVRFTKILSLLRLLRL 300

  Fly   693 YRFWAFMDRTER--HTNY---PNLFRSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVYHD-- 750
            .|...::.:.|.  |..|   ..:.|...||..:|::.||:||:..::.....|.|..||..:
Zfish   301 SRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCMQFMVPMLQDFPSTCWVSKNNM 365

  Fly   751 -SESADVVKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTS 813
             :.:.||  ||..:.:.....:..|| ....|....:....::.::.|...:|..||:..|:|.|
Zfish   366 VNSTWDV--QYSYALFMAMSHMLCIGYGAQAPEGPTDVWLTMISMIIGATCYAMFLGNATNLVQS 428

  Fly   814 VSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAI 878
            :.|:.:::|.|...|:.||...::|..::.::..::::.: ..|..|||..:..|.|.||.|| :
Zfish   429 LDASHRQYQEKYKQVEQYMSFHKLPADMRQRIHDYYEHRF-QGKMFDEENILEELSDPLKEEI-V 491

  Fly   879 NVHLDTL-KRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNG 942
            |.:...| ..:.:|.|.:..|:..|:.:||..:|.|||.|.|:|.:|::||.:..|.:.|:..:.
Zfish   492 NYNCRGLVANMPLFANADPHFVTVLLSKLRFEVFQPGDVIIREGTLGRKMYFIQHGCVSVITSDN 556

  Fly   943 KTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLESI 1007
            |.  ..|..|.|||||.:|..|    |||||||:..|..|:.||.....:||:|.|..|...|::
Zfish   557 KE--KKLNDGCYFGEICLLTRG----RRTASVRADTYCRLYSLSVDSFNEVLEENPLMRRAFENV 615

  Fly  1008 AVKRL 1012
            ||.||
Zfish   616 AVNRL 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	62/269 (23%)
		CAP_ED	890..1004	CDD:237999	44/113 (39%)
		DUF4655	1084..>1154	CDD:317882
hcn3	XP_689197.1	Ion_trans_N	124..166	CDD:285597	11/41 (27%)
		Ion_trans	186..429	CDD:278921	56/247 (23%)
		Ion_trans_2	<377..427	CDD:285168	8/49 (16%)
		Crp	498..>622	CDD:223736	50/129 (39%)
		CAP_ED	504..612	CDD:237999	44/113 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910