DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42260 and kcnh1a

DIOPT Version :9

Sequence 1:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_009291371.1	Gene:	kcnh1a / 560568	ZFINID:	ZDB-GENE-061226-1	Length:	977	Species:	Danio rerio

Alignment Length:	834	Identity:	186/834 - (22%)
Similarity:	327/834 - (39%)	Gaps:	184/834 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   540 PGSHGGQPHHQKPRRTASQRI--------RAATAARKLHFVFDPAGRLCYY---WSMVVSMAFLY 593
            |..|.|:..|:..|.....::        :..|.....|.:.    ..|.:   |..|:.:...|
Zfish   177 PTVHKGENVHKHSRLAEVLQLGSDILPQYKQETPKTPPHIIL----HYCAFKTTWDWVILILTFY 237

  Fly   594 NFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFRTGYL-EDGVLQTDALKLRTHYMN 657
            ...::.|..:|:  .::....|..:|.:.|.::|:||:.:|.|.:: ..|.:.:|...:|.:|:
Zfish   238 TAIMVPYNVSFK--TKQNNVTWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYL- 299

  Fly   658 STIFYIDCLCLLPLDFL-------------YLSIGFNSILRSFRLVKIYRFWAFMDRTERHTNYP 709
            .|.|.||.|..||.|.:             .::.|.:|:..|.::|::.|......:.:.:..|
Zfish   300 KTWFVIDLLSCLPYDVINAFENVDENWNHRAVTQGISSLFSSLKVVRLLRLGRVARKLDHYIEY- 363

  Fly   710 NLFRSTALIHYLLVIF----HWNGCL------YHIIHKN-NGFGSRNWVYHDSES---------- 753
                ..|::..|:.:|    ||..|:      |.:|.:: |...:.:|:|..:||
Zfish   364 ----GAAVLVLLVCVFGLAAHWLACIWYSIGDYEVIDEDRNTVRTDSWLYMLAESIGTPYRFNAS 424

  Fly   754 ----------ADVVKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVILQLLFGLMLFATVLGHV 807
                      .|.|  |:.|.|:...:||:|| ....|.:.||.:|.:..::.|.:|:||:.|:|
Zfish   425 GTGRWEGGPTKDTV--YITSLYFTMTSLTSIGFGNIAPTTDGEKIFAVAMMMIGSLLYATIFGNV 487

  Fly   808 ANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKL 872
            ..|...:.|....:...|:.|:.::::.:||..|..:|:.:....|......|.|:.:...|..:
Zfish   488 TTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIASTWSMSHGIDTEKVLQICPKDM 552

  Fly   873 KAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQV 937
            :|:|.::::....|....|:....|.|..|.:..:.:..:|||.|...||....:..|..|.|:|
Zfish   553 RADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTIHCAPGDLIYHAGESVDSLCFVVSGSLEV 617

  Fly   938 VADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVLKEYPA--- 999
            :.|:  .|:|.|..|..||::....:..|  :..|:||::.|.||.|:.:..:..||:.|.|
Zfish   618 IQDD--EVVAILGKGDVFGDVFWKEVTLA--QACANVRALTYCDLHVIKRDALQKVLEFYTAFSN 678

  Fly  1000 -----------ARVRLESIAV--------KRLEKYKKAP-------------------------- 1019
                       .|.||....:        :||.:..:||
Zfish   679 HFSRNLLLTYNLRKRLVFRKISDVKREEEERLRRKNEAPLNLPPDHPVRRLFQRFRQQKEARLAA 743

  Fly  1020 ---------LEKVKYFNVVAMGRCQSTPGLVESCGRTSLEEMWLPPATAGASSLMHHHQALQQQH 1075
                     |||.:..|.|......:|         ||:..:...|||...|.|: .::.|....
Zfish   744 VRPNSEDSDLEKGQIHNEVISQDVIAT---------TSIVTVTESPATPIPSHLI-KNRTLGPFD 798

  Fly  1076 QASQQQPHRQESTQTSSQTHGYSPRSYADRLARATDSPRSVS--PSAHGSE---ERPRSRTTSHH 1135
            ||....|....|..:..:..|::      |...:...|.|..  |.|...|   ||..|..||..
Zfish   799 QAKLSAPAPNASRMSEPRARGWA------RFRESVAKPESWGNVPKAESMETLPERSSSAKTSEP 857

  Fly  1136 SIRPQSQPSHTGHICDSSSQLECYGAGVGGAGGGTTPLLGSHEVLED-------EIKRLRERLHT 1193
            |...::....:| |..|..:|:        .||..||:..| .|..|       .|..:.|  ||
Zfish   858 SGLKKTDSCDSG-ITKSDLRLD--------EGGIRTPVDRS-PVQPDGKSPPIPPIPTIPE--HT 910

  Fly  1194 VESENQALNTKLSQQQWDLENRLAEIEMQICGVSSTSSVDPENETEELERNRES 1247
            :::....|.|:|.::...|.||:..:|.|:.            |...|.|||:|
Zfish   911 LQASLLELRTELKEELSALGNRMVALEAQVA------------EVLRLLRNRKS 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	65/286 (23%)
		CAP_ED	890..1004	CDD:237999	34/127 (27%)
		DUF4655	1084..>1154	CDD:317882	17/74 (23%)
kcnh1a	XP_009291371.1	PAS_9	46..142	CDD:290162
		PAS	46..140	CDD:238075
		Ion_trans	242..499	CDD:278921	62/266 (23%)
		Ion_trans_2	<439..493	CDD:285168	18/53 (34%)
		Crp	564..>701	CDD:223736	37/140 (26%)
		CAP_ED	570..680	CDD:237999	33/113 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910